BENZETIMIDE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C23H26N2O2.ClH
Molecular Weight	398.926
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.O=C1CCC(C2CCN(CC3=CC=CC=C3)CC2)(C(=O)N1)C4=CC=CC=C4

InChI

InChIKey=XSOOSXRNMDUWEM-UHFFFAOYSA-N

InChI=1S/C23H26N2O2.ClH/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18;/h1-10,20H,11-17H2,(H,24,26,27);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C23H26N2O2
Molecular Weight	362.4647
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1091448 | https://www.ncbi.nlm.nih.gov/pubmed/6055523

Benzetimide, a muscarinic acetylcholine receptor antagonist that was investigated as an antiparkinson-agent and was studied in the treatment of diarrheas of cattle and calves. Benzetimide is an enantiomer of dexetimide that has been used to treat neuroleptic-induced Parkinsonism.

Approval Year

PubMed

Title	Date	PubMed
Sequential 123I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and 18F-FDG PET imaging).	2005 Feb	15449046
Defects in muscarinic receptor-coupled signal transduction in isolated parotid gland cells after in vivo irradiation: evidence for a non-DNA target of radiation.	2005 Feb 14	15668705
Reduced posterior cingulate binding of I-123 iodo-dexetimide to muscarinic receptors in mild Alzheimer's disease.	2005 May	15925773
Synthesis and structure-activity relationship of benzetimide derivatives as human CXCR3 antagonists.	2008 Nov 1	18922694

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:35:44 GMT 2023` Edited by `admin` on `Fri Dec 15 17:35:44 GMT 2023`
Record UNII	V6ERX20PHB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENZETIMIDE HYDROCHLORIDE

Official Name

English

JANSSEN-R-492

Code

English

BENZETIMIDE HCL

Common Name

English

MCN-JR-4929-11

Code

English

JANSSEN R 492

Code

English

(3,4'-BIPIPERIDINE)-2,6-DIONE, 3-PHENYL-1'-(PHENYLMETHYL)-, MONOHYDROCHLORIDE

Common Name

English

DIOXATRINE

Brand Name

English

2-(1-Benzyl-4-piperidyl)-2-phenylglutarimide monohydrochloride

Systematic Name

English

BENZETIMIDE HYDROCHLORIDE [USAN]

Common Name

English

BENZETIMIDE HYDROCHLORIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29704