DEXETIMIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H26N2O2
Molecular Weight	362.4647
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1CC[C@@](C2CCN(CC3=CC=CC=C3)CC2)(C(=O)N1)C4=CC=CC=C4

InChI

InChIKey=LQQIVYSCPWCSSD-HSZRJFAPSA-N

InChI=1S/C23H26N2O2/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,24,26,27)/t23-/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4947805 | https://www.ncbi.nlm.nih.gov/pubmed/4581374 | https://www.ncbi.nlm.nih.gov/pubmed/1020682 | De Deyn (1997) A Textbook Of: SPECT in Neurology and Psychiatry, page 20, retrieved from: https://books.google.ru/books?id=OdNnFrWm9SsC

Dexetimide is a potent central and peripheral anticholinergic agent. It has a high affinity for all subtypes of muscarinic receptor and a long duration action. It forms very stable complex with mAChR. Dexetimide was used for many years in Europe for the treatment of extrapyramidal disorders. Neuroleptic-induced parkinsonian symptoms are effectively controlled by dexetimide. It is a safe, potent, and long-acting antiparkinsonian agent.

Approval Year

PubMed

Title	Date	PubMed
A quantitative study of neuroleptic-induced extrapyramidal symptoms and their response to dexetimide, a potent and long-acting antiparkinsonian agent.	1971	4947805
Dexetimide (R 16470) in the control of neuroleptic-induced extrapyramidal side-effects. Its prophylactic value and duration of action.	1973 Jul-Aug	4581374
Subclassification of muscarinic receptors in the heart, urinary bladder and sympathetic ganglia in the pithed rat. Selectivity of some classical agonists.	1985 Dec	4094621
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.	1998 Feb	9454790

Sample Use Guides

In Vivo Use Guide

Dosages ranged from 0.5 to 1.5 mg daily

Route of Administration: Oral

Name

Type

Language

DEXETIMIDE

Official Name

English

(+)-2-(1-BENZYL-4-PIPERIDYL)-2-PHENYLGLUTARIMIDE

Systematic Name

English

BENZETIMIDE, (S)-

Common Name

English

dexetimide [INN]

Common Name

English

DEXETIMIDE [MI]

Common Name

English

DEXETIMIDE [MART.]

Common Name

English

R 16,470 FREE BASE

Code

English

R-16470 FREE BASE

Code

English

(3,4'-BIPIPERIDINE)-2,6-DIONE, 3-PHENYL-1'-(PHENYLMETHYL)-, (S)-

Systematic Name

English

Dexetimide [WHO-DD]

Common Name

English

DEXETIMIDE [USAN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QN04AA08