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Restrict the search for
m nalidixic acid
to a specific field?
Status:
Investigational
Source:
USAN:LEVALBUTEROL SULFATE [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
Radiother Oncol. Mar 2004;70(3):295-9.: Phase 3 Human clinical trial Completed N/A
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Misonidazole is a nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free radicals and depletes radioprotective thiols, thereby sensitizing hypoxic cells to the cytotoxic effects of ionizing radiation. This single-strand breaks in DNA induced by this agent result in the inhibition of DNA synthesis. The drug also possesses a substantial cytotoxic effect, independent of radiation, which is selectively expressed in hypoxic cells. Misonidazole may be cytotoxic to the normal hypoxic tissues in the human body, making this became a major concern in the clinical application of the drug. Misonidazole leads to strand breaks in cellular DNA and those cells which fail to survive also fail to repair these strand breaks. Misonidazole depletes intracellular glutathione and is more toxic in glutathione depleted cells.
Status:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Acetyltannic acid is an astringent (intestinal) for foals, calves, dogs. It is used for treatment of diarrhoea.
Status:
Investigational
Source:
NCT01000493: Phase 2 Interventional Completed Post-Traumatic Stress Disorder
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Orvepitant is a novel generation brain penetrant, selective and potent, small molecule NK-1 receptor antagonist. Orvepitant’s (GW823296) mode of action and developability characteristics made it a suitable development candidate for the treatment of common anxiety disorders, posttraumatic stress disorder and major depressive disorder. It’s in phase II clinical trials as an effective inhibitor of itch-associated response.
Status:
Investigational
Source:
INN:sodium hexacyclonate [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Hexacyclonic Acid (aka gevilon) has been clinically demonstrated to produce hypolipidemic effects. It has been investigated as a treatment for coronary heart disease, and hypertensive disease with severe lipid metabolic disturbances. Gevilon has been found to have a hypolipidemic effect in reducing the levels of total cholesterol, beta-cholesterol, triglycerides, increasing alpha-cholesterol levels and normalizing the atherogenicity coefficient; especially in patients with Type IIb dyslipoproteinemia.
Status:
Investigational
Source:
NCT01327027: Phase 1 Interventional Completed Healthy
(2011)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Class (Stereo):
CHEMICAL (UNKNOWN)
Ganglefene is a coronary vasodilator. This n-cholinoblocker was originally studied for its effects on coronary circulation in angina pectoris. Animal studies have also shown shortened recovery period of motor functions after ganglefene administration. One rodent study showed that modulation of the n-cholinergic system by ganglefene in the developing fetal brain leads to changes in the quantitative and qualitative characteristics of elements of sexual behavior in pubescent offspring.
Class (Stereo):
CHEMICAL (ACHIRAL)
Nifuralide, a 5-nitrofuran derivative, is an antibacterial agent. It was used for controlling Salmonella choleraesuis in swine. The mode of action of 5-nitrofuran analogues is based on red-ox biotransformation.
Class (Stereo):
CHEMICAL (ABSOLUTE)
ISATORIBINE, a guanosine analog, is an immunopotentiating agent. It is a selective agonist of toll‐like receptor 7, a pattern-recognition receptor that activates the innate immune response.
Class (Stereo):
CHEMICAL (RACEMIC)
Iolixanic Acid is triiodophenoxyalkoxyalkanoic acid derivative patented by Bracco Industria Chimica S.p.A. as a diagnostic agent for cholecystography and urinary tract imaging
