CROTONIAZIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H11N3O
Molecular Weight	189.2138
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C\C=C\C=N\NC(=O)C1=CC=NC=C1

InChI

InChIKey=YLWYNCPRXFCNLQ-WYIUXTECSA-N

InChI=1S/C10H11N3O/c1-2-3-6-12-13-10(14)9-4-7-11-8-5-9/h2-8H,1H3,(H,13,14)/b3-2+,12-6+

HIDE SMILES / InChI

Molecular Formula	C10H11N3O
Molecular Weight	189.2138
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	2
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13069348 | https://www.ncbi.nlm.nih.gov/pubmed/13647448 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 322, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Crotoniazide is a derivative of isonicotinic hydrazide. Crotoniazide demonstrated antituberculous activity in vitro and in vivo.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Tuberculosis 83 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13069348 https://www.ncbi.nlm.nih.gov/pubmed/13903004 https://www.ncbi.nlm.nih.gov/pubmed/13647448	Curative		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
The effect of crotonylidene isonicotinic acid hydrazone (CIH) and mesityl oxide hydrazone (MIH) in experimental tuberculosis.	1962-01-01	13903004
[Antituberculous activity of crotonylidene-isoniazid].	1959	13647448
Antitubercular substances. II. Substitution products of isonicotinic hydrazide.	1953-08	13069348

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:30:07 GMT 2025` Edited by `admin` on `Mon Mar 31 18:30:07 GMT 2025`
Record UNII	C4DT7VL6FU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

4-PYRIDINECARBOXYLIC ACID, 2-(2-BUTENYLIDENE)HYDRAZIDE

Preferred Name

English

CROTONIAZIDE

Official Name

English

crotoniazide [INN]

Common Name

English

ISONICOTINIC ACID 2-BUTENYLIDENEHYDRAZIDE

Common Name

English

CROTONYLIDENISONIAZID

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394