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Restrict the search for
m nalidixic acid
to a specific field?
Status:
Investigational
Source:
NCT00000791: Phase 2 Interventional Completed HIV Infections
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Glycovir (SC-49483) is an ester produg (a biologically inactive compound that can be metabolized in the body to produce a drug) of SC 48334, an α-glycosidase 1 inhibitor that has anti-HIV activity. Glycovir was thus studied for treatment in HIV. It is targeted against viral glycoprotein processing in host cell endoplasmic reticulum. Bioavailability of the pharmacologically active SC-48334 observed after glycovir administration was found to be very different between species, but monkeys are a good animal model for prediction of bioavailability of SC-48334 in humans. A phase II trial was conducted to determine the safety and anti-HIV activity of a combination treatment of glycovir with zidovudine (AZT).
Status:
Investigational
Source:
INN:broxitalamic acid [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Broxitalamic acid is tribromobenzoic acid derivative used as x-ray contrast medium
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Enfenamic acid (under brand name tromaril) is an anthranilic acid derivative with potent anti-inflammatory, anti-arthritic, analgesic and antipyretic actions. It has additional unique property of anti-platelet aggregation activity, without disturbing any other blood coagulation factors. It also differs from other non-steroidal anti-inflammatory agents like indomethacin, in producing diuresis and natriuresis. In the clinical study, tromaril showed itself as a strong and effective drug for use in various eye diseases.
Class (Stereo):
CHEMICAL (EPIMERIC)
Enilospirone (CERM-3726) is essentially a central stimulant. At low doses (100 mg) it may improve performance and at higher doses it may lead to disturbance of sleep continuity. These effects may not involve DA mechanisms, though changes such as those in REM sleep with chronic ingestion could involve the noradrenergic pathway. The property of the drug, even at low doses, to oppose the deterioration in performance associated with tests of prolonged duration is likely to be due to a mild alerting effect.
Status:
Investigational
Source:
INN:cicrotoic acid [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Cicrotoic acid is a biochemical drug that acts on bile flow and liquid composition of human bile.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Fuzlocillin is a penicillin antibiotic. This semisynthetic acylureidopenicillin with antibacterial activity binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Fuzlocillin (furazlocillin), has been shown to be highly specific for the FtsI gene. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing the cell to break down (cell lysis). Among the acylureidopenicillins, furaclocillin exerts increased activity against Escherischia coli, Klebsiella, Proteus and Pseudomonas aeruginosa.
Status:
Investigational
Source:
INN:merimepodib [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Merimepodib has immunosuppressive activity. It targets hepatitis C indirectly through the inhibition of inositol monophosphate dehydrogenase, which exerts an acute antiproliferative effect on lymphocyte proliferation due to their almost exclusive dependence on the de novo pathway for synthesis of guanosine. Phase II clinical trial study of merimepodib for the treatment of HCV infection and psoriasis were completed. The poor pharmacokinetic-pharmacodynamic results have resulted in discontinuation of clinical trials.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Moquizone is quinazolinone derivative with choleretic and antifibrillatory activity. Oral toxic doses of Moquizone exerted depressant effects, whereas parenteral toxic doses exerted stimulant effects on the central nervous system.
Status:
Investigational
Source:
NCT00834184: Phase 1 Interventional Completed Healthy
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Nikkomycin Z is an antifungal drug that inhibits chitin synthase. It has been reported that it inhibits chitin synthases (Chs) 1 and 3, but not 2, of Saccharomyces cerevisiae. Later it was found that nikkomycin Z inhibited all three Chs isozymes of Candida albicans (CaChs). The IC(50) value for CaChs1 is 15 uM, for CaChs2 0.8 uM, and for CaChs3 13 uM. Nikkomycin Z is under development as an orphan product for treatment of coccidioidomycosis. Nikkomycin Z has been used in trials studying the treatment and basic science of Coccidioidomycosis. In February 2006, nikkomycin z was designated as an orphan drug for the treatment of Coccidioidomycosis.
Class (Stereo):
CHEMICAL (UNKNOWN)
ISOPROFEN is an anti-inflammatory agent with analgesic and antipyretic properties. Its anti-inflammatory potency is greater than that of phenylbutazone but lower than that of indomethacin. Its antipyretic action can be explained by an effect of this substance on the metabolism of arachidonic acid in the brain.
