ENILOSPIRONE

Details

Stereochemistry	EPIMERIC
Molecular Formula	C15H18ClNO3
Molecular Weight	295.761
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 3
E/Z Centers	0
Charge	0
Stereo Comments	5-OXAZONE

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1OC2(CCCC[C@H]2OC3=CC(Cl)=CC=C3)NC1=O

InChI

InChIKey=PSHBCUHYCLAGPZ-BAOLWLNASA-N

InChI=1S/C15H18ClNO3/c1-10-14(18)17-15(20-10)8-3-2-7-13(15)19-12-6-4-5-11(16)9-12/h4-6,9-10,13H,2-3,7-8H2,1H3,(H,17,18)/t10-,13-,15?/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6805026

Enilospirone (CERM-3726) is essentially a central stimulant. At low doses (100 mg) it may improve performance and at higher doses it may lead to disturbance of sleep continuity. These effects may not involve DA mechanisms, though changes such as those in REM sleep with chronic ingestion could involve the noradrenergic pathway. The property of the drug, even at low doses, to oppose the deterioration in performance associated with tests of prolonged duration is likely to be due to a mild alerting effect.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
6-(3-chloro)-phenoxy-2-methyl-1-oxa-4-azospiro-[4,5]decane-3-one (CERM 3726) and sleep of healthy men.	1982	6805026
Enhancement of pharmacological activity of CERM 3726 with a ground mixture of beta-cyclodextrin in mice.	1987	3441478

Sample Use Guides

In Vivo Use Guide

Immediate effects on sleep of 100, 200 and 300 mg enilospirone were studied in six healthy males.

Route of Administration: Oral

Name

Type

Language

ENILOSPIRONE

Official Name

English

enilospirone [INN]

Common Name

English

(2R,5RS,6R)-6-(M-CHLOROPHENOXY)-2-METHYL-1-OXA-4-AZASPIRO(4.5)DECAN-3-ONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197