GLYCOVIR

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H45NO8
Molecular Weight	499.6374
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCN1C[C@H](OC(=O)CCC)[C@@H](OC(=O)CCC)[C@H](OC(=O)CCC)[C@H]1COC(=O)CCC

InChI

InChIKey=MKGDNVHZSCXBKR-KYVQNOJUSA-N

InChI=1S/C26H45NO8/c1-6-11-16-27-17-20(33-22(29)13-8-3)26(35-24(31)15-10-5)25(34-23(30)14-9-4)19(27)18-32-21(28)12-7-2/h19-20,25-26H,6-18H2,1-5H3/t19-,20+,25-,26-/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7494828 | https://www.ncbi.nlm.nih.gov/pubmed/8923673 | https://clinicaltrials.gov/ct2/show/study/NCT00000791?term=SC-49483&rank=1

Glycovir (SC-49483) is an ester produg (a biologically inactive compound that can be metabolized in the body to produce a drug) of SC 48334, an α-glycosidase 1 inhibitor that has anti-HIV activity. Glycovir was thus studied for treatment in HIV. It is targeted against viral glycoprotein processing in host cell endoplasmic reticulum. Bioavailability of the pharmacologically active SC-48334 observed after glycovir administration was found to be very different between species, but monkeys are a good animal model for prediction of bioavailability of SC-48334 in humans. A phase II trial was conducted to determine the safety and anti-HIV activity of a combination treatment of glycovir with zidovudine (AZT).

Approval Year

Name

Type

Language

GLYCOVIR

Common Name

English

NSC-670880

Code

English

SC-49483

Common Name

English

BUTANOIC ACID, 1,1',1''-((2R,3R,4R,5S)-1-BUTYL-2-((1-OXOBUTOXY)METHYL)-3,4,5-PIPERIDINETRIYL) ESTER

Common Name

English

Code System Code Type Description

NSC

670880