Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H15NO2 |
| Molecular Weight | 241.2851 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=C(NCCC2=CC=CC=C2)C=CC=C1
InChI
InChIKey=HLNLBEFKHHCAMV-UHFFFAOYSA-N
InChI=1S/C15H15NO2/c17-15(18)13-8-4-5-9-14(13)16-11-10-12-6-2-1-3-7-12/h1-9,16H,10-11H2,(H,17,18)
Enfenamic acid (under brand name tromaril) is an anthranilic acid derivative with potent anti-inflammatory, anti-arthritic, analgesic and antipyretic actions. It has additional unique property of anti-platelet aggregation activity, without disturbing any other blood coagulation factors. It also differs from other non-steroidal anti-inflammatory agents like indomethacin, in producing diuresis and natriuresis. In the clinical study, tromaril showed itself as a strong and effective drug for use in various eye diseases.
Approval Year
Sample Use Guides
Incubation of liver cells in the presence of 1.0 mM enfenamic acid inhibited the output of glucose. And also the in vitro addition of various concentrations of enfenamic acid (0.25 to 3.0 mM) to the tissue extracts of liver inhibited the activities of important gluconeogenic enzymes such as pyruvate carboxylase (PC), phosphoenolpyruvate carboxykinase (PEPCK) and fructose 1,6-diphosphatase (FDPase). These findings indicated that the impairment of gluconeogenesis might be due to the inactivation of the enzymes by the drug.
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NCI_THESAURUS |
C257
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ACTIVE MOIETY
