MOQUIZONE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H21N3O3
Molecular Weight	351.399
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MOQUIZONE

Structure Search

SMILES

O=C(CN1CCOCC1)N2CN(C(=O)C3=CC=CC=C23)C4=CC=CC=C4

InChI

InChIKey=VCRQLDNIOXNDMT-UHFFFAOYSA-N

InChI=1S/C20H21N3O3/c24-19(14-21-10-12-26-13-11-21)23-15-22(16-6-2-1-3-7-16)20(25)17-8-4-5-9-18(17)23/h1-9H,10-15H2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4679063 | https://www.ncbi.nlm.nih.gov/pubmed/5422206 | https://www.ncbi.nlm.nih.gov/pubmed/5536425 | https://pubs.acs.org/doi/abs/10.1021/jm00312a007

Moquizone is quinazolinone derivative with choleretic and antifibrillatory activity. Oral toxic doses of Moquizone exerted depressant effects, whereas parenteral toxic doses exerted stimulant effects on the central nervous system.

Originator

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
bile acid metabolic process 2 Target ID: GO:0008206 Sources: http://www.drugfuture.com/chemdata/moquizone.html\|https://www.ncbi.nlm.nih.gov/pubmed/4679063	Modulator 828

PubMed

PubMed

Title	Date	PubMed
Pharmacology of moquizone, a new choleretic drug.	1972 Nov	4679063

Patents

Patents

Sample Use Guides

In Vivo Use Guide

Mice LD50: 560mg/kg

Route of Administration: Intraperitoneal

Name

Type

Language

MOQUIZONE

Official Name

English

2,3-DIHYDRO-1-(MORPHOLINOACETYL)-3-PHENYL-4(1H)-QUINAZOLINONE

Systematic Name

English

moquizone [INN]

Common Name

English

MOQUIZONE [MI]

Common Name

English

Moquizone [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66913

Created by admin on Fri Dec 15 16:30:05 GMT 2023 , Edited by admin on Fri Dec 15 16:30:05 GMT 2023

Code System Code Type Description

ChEMBL

CHEMBL2105182

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MESH

C002376

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DRUG CENTRAL

3785

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PUBCHEM

63216

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ECHA (EC/EINECS)

243-021-2

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SMS_ID

100000080366

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CAS

19395-58-5

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NCI_THESAURUS

C66192

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EVMPD

SUB09061MIG

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EPA CompTox

DTXSID60173007

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MERCK INDEX

m354

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Merck Index

INN

2589

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FDA UNII

EG12MD1RMA

Created by admin on Fri Dec 15 16:30:05 GMT 2023 , Edited by admin on Fri Dec 15 16:30:05 GMT 2023

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ACTIVE MOIETY


					EG12MD1RMA

MOQUIZONE

SALT/SOLVATE (PARENT)


					51I2PZ39ND

MOQUIZONE HYDROCHLORIDE