ROXIBOLONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H28O5
Molecular Weight	360.444
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C(=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C)C(O)=O

InChI

InChIKey=JOFBZBDWOWPUMO-QARKFJNLSA-N

InChI=1S/C21H28O5/c1-19-9-13(18(24)25)15(22)8-11(19)4-5-12-14-6-7-21(3,26)20(14,2)10-16(23)17(12)19/h8-9,12,14,16-17,23,26H,4-7,10H2,1-3H3,(H,24,25)/t12-,14-,16-,17+,19-,20-,21-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6523544 | https://www.ncbi.nlm.nih.gov/pubmed/3790189

Roxibolone, an androstane derivative, possesses the anti-glucocorticoid activity and devoid of any affinity for the androgenic prostate and muscle receptors. This anabolic drug has never been marketed.

Approval Year

PubMed

Title	Date	PubMed
Androstane derivatives--roxibolone and decylroxibolone--devoid of any affinity for the androgenic prostate and muscle receptors.	1986-09	3790189
Activity of a new androstane derivative on the nitrogen metabolism: antiglucocorticoid effects.	1985-11	3833263
Synthesis of 2-carboxy-11 beta, 17 beta-dihydroxy-17-methyl-1, 4-androstadien-3-one and related compounds.	1984-03	6523544

Patents

Name

Type

Language

ROXIBOLONE

Official Name

English

BR-906

Preferred Name

English

roxibolone [INN]

Common Name

English

ANDROSTA-1,4-DIENE-2-CARBOXYLIC ACID, 11,17-DIHYDROXY-17-METHYL-3-OXO-, (11.BETA.,17.BETA.)-

Common Name

English

11.BETA.,17.BETA.-DIHYDROXY-17-METHYL-3-OXOANDROSTA-1,4-DIENE-2-CARBOXYLIC ACID

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2360