CROTONIAZIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H11N3O
Molecular Weight	189.2138
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure of CROTONIAZIDE

Structure Search

SMILES

C\C=C\C=N\NC(=O)C1=CC=NC=C1

InChI

InChIKey=YLWYNCPRXFCNLQ-WYIUXTECSA-N

InChI=1S/C10H11N3O/c1-2-3-6-12-13-10(14)9-4-7-11-8-5-9/h2-8H,1H3,(H,13,14)/b3-2+,12-6+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13069348 | https://www.ncbi.nlm.nih.gov/pubmed/13647448 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 322, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Crotoniazide is a derivative of isonicotinic hydrazide. Crotoniazide demonstrated antituberculous activity in vitro and in vivo.

Originator

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Tuberculosis 83 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13069348 https://www.ncbi.nlm.nih.gov/pubmed/13903004 https://www.ncbi.nlm.nih.gov/pubmed/13647448	Curative		Preclinical	Unknown Approved Use Unknown

PubMed

PubMed

Title	Date	PubMed
Antitubercular substances. II. Substitution products of isonicotinic hydrazide.	1953 Aug	13069348
[Antituberculous activity of crotonylidene-isoniazid].	1959	13647448
The effect of crotonylidene isonicotinic acid hydrazone (CIH) and mesityl oxide hydrazone (MIH) in experimental tuberculosis.	1962 Jan 1	13903004

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

CROTONIAZIDE

Official Name

English

crotoniazide [INN]

Common Name

English

4-PYRIDINECARBOXYLIC ACID, 2-(2-BUTENYLIDENE)HYDRAZIDE

Common Name

English

ISONICOTINIC ACID 2-BUTENYLIDENEHYDRAZIDE

Common Name

English

CROTONYLIDENISONIAZID

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394

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Code System Code Type Description

EVMPD

SUB06830MIG

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ChEMBL

CHEMBL2106585

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FDA UNII

C4DT7VL6FU

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PUBCHEM

5369886

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NCI_THESAURUS

C76260

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INN

1080

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EPA CompTox

DTXSID8046113

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SMS_ID

100000083723

Created by admin on Fri Dec 15 16:30:51 GMT 2023 , Edited by admin on Fri Dec 15 16:30:51 GMT 2023

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CAS

7007-96-7

Created by admin on Fri Dec 15 16:30:51 GMT 2023 , Edited by admin on Fri Dec 15 16:30:51 GMT 2023

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ACTIVE MOIETY


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