Etocarlide (4,4'-dihydroxythiocarbanilide) is an antibiotic active against Mycobacterium tuberculosis.

Q203 (6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)imidazo [1,2-a]pyridine-3-carboxamide) is an an imidazopyridine antitubercular compound. Q203 targets the cytochrome b subunit (QcrB) of the cytochrome bc1 complex. This complex is an essential component of the respiratory electron transport chain of ATP synthesis. Q203 inhibited the growth of multidrug-resistant (MDR) and extensively drug-resistant (XDR) M. tuberculosis clinical isolates in culture broth medium in the low nanomolar range and was efficacious in a mouse model of tuberculosis at a dose less than 1 mg per kg body weight, which highlights the potency of this compound. In addition, Q203 displays pharmacokinetic and safety profiles compatible with once-daily dosing. Q203 is a promising new clinical candidate for the treatment of tuberculosis.

Streptoniazid is a streptomycin derivative patented by Societe des usines chimiques de Rhone-Poulenc as antibiotic effective against tuberculosis.

Subathizone (also known as Berculon B) is a thiosemicarbazone derivative useful for the chemotherapy of tuberculosis. In preclinical models, Subathizone shows potent activity in experimental tuberculosis in the mouse. In clinical trial, Subathizone shows moderate efficacy and frequent adverse events. Gastrointestinal disturbances and progressive anemia were the most toxic effects, but liver dysfunction, malaise, depression and lassitude, exanthemata, and conjunctival irritation also occurred.

Ftormetazine was studied as a psychotropic and an antiarrhythmic agent. Information about the current use of this compound is not available.

Rifametane (SPA-S-565) is a semisynthetic derivative of rifamycin (a natural antibiotic produced by Amycolatopsis rifamycinica). It was being evaluated for treatment of bacterial infections. A phase I study showed that administration of rifametane is safe with minor, reversible adverse events such as mild headache, metallic taste and slightly elevated temperature for 3 to 4 hours. Rifametane has anti-tuberculosis activity and was suggested to be a good candidate for phase II clinical trials.

Nicothiazone (nicotinaldehyde thiosemicarbazone), an antituberculosis drug, was apparently responsible for inducing vacuoles in the corneal epithelium and thus caused discomfort and photophobia from corneal disturbance.

Verazide, which is related to Isoniazid has been developed in Australia for the treatment of pulmonary tuberculosis. It is equally effective as Isoniazid and less toxic.

OPINIAZIDE (also known as saluzid) was used for the treatment of meningeal tuberculosis in adults and in children. Information about the current use of this drug is not available.

Aconiazide, the isonicotinylhydrazone of 2-formylphenoxyacetic acid, has been used in the treatment and prophylaxis of tuberculosis. Aconiazide is a pro-drug of isoniazid which was designed to be less toxic than the parent drug. Aconiazide is hydrolyzed in the body to isoniazid and 2-formylphenoxyacetic acid. 2-Formylphenoxyacetic acid has been shown to bind hydrazine and acetylhydrazine. This binding could explain the lower toxicity of aconiazide and also could provide a reason for postulating its lack of carcinogenicity.