Subathizone (also known as Berculon B) is a thiosemicarbazone derivative useful for the chemotherapy of tuberculosis. In preclinical models, Subathizone shows potent activity in experimental tuberculosis in the mouse. In clinical trial, Subathizone shows moderate efficacy and frequent adverse events. Gastrointestinal disturbances and progressive anemia were the most toxic effects, but liver dysfunction, malaise, depression and lassitude, exanthemata, and conjunctival irritation also occurred.