NICOTHIAZONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H8N4S
Molecular Weight	180.23
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=S)N\N=C\C1=CC=CN=C1

InChI

InChIKey=ABWLRVJYVVQTGQ-BJMVGYQFSA-N

InChI=1S/C7H8N4S/c8-7(12)11-10-5-6-2-1-3-9-4-6/h1-5H,(H3,8,11,12)/b10-5+

HIDE SMILES / InChI

Molecular Formula	C7H8N4S
Molecular Weight	180.23
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://books.google.ru/books?id=mDLYCQAAQBAJ&pg=PA1043&lpg=PA1043&dq=NICOTHIAZONE&source=bl&ots=RVZKQoZtqp&sig=AvbpEvHoHsKgli6R79IJb356Xl0&hl=ru&sa=X&ved=0ahUKEwjHoZ-XhITYAhUmM5oKHVQgCR4Q6AEIZzAO#v=onepage&q=NICOTHIAZONE&f=false

Nicothiazone (nicotinaldehyde thiosemicarbazone), an antituberculosis drug, was apparently responsible for inducing vacuoles in the corneal epithelium and thus caused discomfort and photophobia from corneal disturbance.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Tuberculosis 83 Sources: Grant, W.M. and Schuman, J.S. (1993) Toxicology of the eye, page 1043, retrieved from: https://books.google.ru/books?id=mDLYCQAAQBAJ	Primary		Withdrawn	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Inactivation of herpes simplex virus by thiosemicarbazones and certain cations.	1974 Apr	15825395
EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.	2007 Mar	17220416

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:54 GMT 2023` Edited by `admin` on `Fri Dec 15 15:57:54 GMT 2023`
Record UNII	2MR9VJF32M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NICOTHIAZONE

Official Name

English

NSC-730

Code

English

nicothiazone [INN]

Common Name

English

NICOTINALDEHYDE THIOSEMICARBAZONE

Systematic Name

English

HYDRAZINECARBOTHIOAMIDE, 2-(3-PYRIDINYLMETHYLENE)-

Systematic Name

English

SRI-286

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C280