VERAZIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H15N3O3
Molecular Weight	285.2979
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(\C=N\NC(=O)C2=CC=NC=C2)C=C1OC

InChI

InChIKey=HPXIKMBHOXLFOR-LICLKQGHSA-N

InChI=1S/C15H15N3O3/c1-20-13-4-3-11(9-14(13)21-2)10-17-18-15(19)12-5-7-16-8-6-12/h3-10H,1-2H3,(H,18,19)/b17-10+

HIDE SMILES / InChI

Molecular Formula	C15H15N3O3
Molecular Weight	285.2979
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.karger.com/Article/Pdf/191902 | https://www.ncbi.nlm.nih.gov/pubmed/13559656

Verazide, which is related to Isoniazid has been developed in Australia for the treatment of pulmonary tuberculosis. It is equally effective as Isoniazid and less toxic.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Tuberculosis 83 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13559656 https://www.ncbi.nlm.nih.gov/pubmed/13458717 https://www.ncbi.nlm.nih.gov/pubmed/13272716 https://www.ncbi.nlm.nih.gov/pubmed/13686822	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Chemotherapy of tuberculosis. III. Verazide in the treatment of pulmonary tuberculosis.	1958 Aug	13559656
New agents active against Mycobacterium avium complex selected by molecular topology: a virtual screening method.	2004 Jan	14645324

Patents

Sample Use Guides

In Vivo Use Guide

Mice: Verazide at 10 mg/kg at weekly intervals exhibits a fair degree of activity, and at 30 mg/kg almost completely heals tuberculosis ulcers with only 3 injections.

Route of Administration: Intramuscular

In Vitro Use Guide

The high in vitro activity of Verazide is 0.06 ug/ml

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:33 GMT 2023` Edited by `admin` on `Fri Dec 15 15:57:33 GMT 2023`
Record UNII	XO8D6I4I5L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

VERAZIDE

Official Name

English

4-PYRIDINECARBOXYLIC ACID, ((3,4-DIMETHOXYPHENYL)METHYLENE)HYDRAZIDE

Common Name

English

NSC-180261

Code

English

VERATRALDEHYDE ISONICOTINOYLHYDRAZONE

Systematic Name

English

N'-VERATRYLIDENEISONIAZID

Common Name

English

ISONICOTINIC ACID, VERATRYLIDENEHYDRAZIDE

Common Name

English

verazide [INN]

Common Name

English

NICOTAZIDE

Common Name

English

4-PYRIDINECARBOXYLIC ACID, 2-((3,4-DIMETHOXYPHENYL)METHYLENE)HYDRAZIDE

Common Name

English

VERAZIDE [MI]

Common Name

English

3,4-DIMETHOXYBENZALDEHYDE ISONICOTINOYLHYDRAZONE

Systematic Name

English

1-ISONICOTINOYL-2-VERATRYLIDENEHYDRAZINE

Systematic Name

English

VERAZINA

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C280