Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H13N3O4 |
| Molecular Weight | 299.2814 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)COC1=C(\C=N\NC(=O)C2=CC=NC=C2)C=CC=C1
InChI
InChIKey=MDFXJBQEWLCGHP-RQZCQDPDSA-N
InChI=1S/C15H13N3O4/c19-14(20)10-22-13-4-2-1-3-12(13)9-17-18-15(21)11-5-7-16-8-6-11/h1-9H,10H2,(H,18,21)(H,19,20)/b17-9+
| Molecular Formula | C15H13N3O4 |
| Molecular Weight | 299.2814 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Aconiazide, the isonicotinylhydrazone of 2-formylphenoxyacetic acid, has been used in the treatment and prophylaxis of tuberculosis. Aconiazide is a pro-drug of isoniazid which was designed to be less toxic than the parent drug. Aconiazide is hydrolyzed in the body to isoniazid and 2-formylphenoxyacetic acid. 2-Formylphenoxyacetic acid has been shown to bind hydrazine and acetylhydrazine. This binding could explain the lower toxicity of aconiazide and also could provide a reason for postulating its lack of carcinogenicity.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:31:23 GMT 2023
by
admin
on
Fri Dec 15 15:31:23 GMT 2023
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| Record UNII |
8OKQ9NS8MO
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| Record Status |
Validated (UNII)
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| Record Version |
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Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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FDA ORPHAN DRUG |
28288
Created by
admin on Fri Dec 15 15:31:23 GMT 2023 , Edited by admin on Fri Dec 15 15:31:23 GMT 2023
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NCI_THESAURUS |
C280
Created by
admin on Fri Dec 15 15:31:23 GMT 2023 , Edited by admin on Fri Dec 15 15:31:23 GMT 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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Aconiazide
Created by
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DTXSID8046292
Created by
admin on Fri Dec 15 15:31:23 GMT 2023 , Edited by admin on Fri Dec 15 15:31:23 GMT 2023
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C76467
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admin on Fri Dec 15 15:31:23 GMT 2023 , Edited by admin on Fri Dec 15 15:31:23 GMT 2023
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13410-86-1
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admin on Fri Dec 15 15:31:23 GMT 2023 , Edited by admin on Fri Dec 15 15:31:23 GMT 2023
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C028354
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6433573
Created by
admin on Fri Dec 15 15:31:23 GMT 2023 , Edited by admin on Fri Dec 15 15:31:23 GMT 2023
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SUB05246MIG
Created by
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8OKQ9NS8MO
Created by
admin on Fri Dec 15 15:31:23 GMT 2023 , Edited by admin on Fri Dec 15 15:31:23 GMT 2023
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100000087670
Created by
admin on Fri Dec 15 15:31:23 GMT 2023 , Edited by admin on Fri Dec 15 15:31:23 GMT 2023
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CHEMBL1590674
Created by
admin on Fri Dec 15 15:31:23 GMT 2023 , Edited by admin on Fri Dec 15 15:31:23 GMT 2023
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1316
Created by
admin on Fri Dec 15 15:31:23 GMT 2023 , Edited by admin on Fri Dec 15 15:31:23 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
