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Status:
US Previously Marketed
Source:
TUBOCURARINE CHLORIDE by BRISTOL MYERS SQUIBB
(1945)
Source URL:
First approved in 1945
Source:
TUBOCURARINE CHLORIDE by BRISTOL MYERS SQUIBB
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Tubocurarine, a naturally occurring alkaloid, is used to treat smoking withdrawl syndrom. Tubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarine's positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH. Tubocurarine competes with acetylcholine for post-synaptic nicotinic NM receptors and blocks them.
Status:
US Previously Marketed
First approved in 1944
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
First approved in 1944
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
First approved in 1944
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
First approved in 1944
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
First approved in 1944
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
Source:
AMINOHIPPURATE SODIUM by MERCK
(1944)
Source URL:
First approved in 1944
Source:
AMINOHIPPURATE SODIUM by MERCK
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid. Aminohippuric acid sodium salt is an agent to measure effective renal plasma flow (ERPF).
Status:
US Previously Marketed
First approved in 1944
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
Source:
Sulfapyrazine by Mead Johnson
(1944)
Source URL:
First approved in 1944
Source:
Sulfapyrazine by Mead Johnson
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
US Previously Marketed
First approved in 1943
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
MERALLURIDE ACID is an organomercuric compound. It was used as a diuretic in a 1:1 mixture with theophylline.