U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 158531 - 158540 of 167129 results

Tubocurarine, a naturally occurring alkaloid, is used to treat smoking withdrawl syndrom. Tubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarine's positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH. Tubocurarine competes with acetylcholine for post-synaptic nicotinic NM receptors and blocks them.
Status:
US Previously Marketed
Source:
Furmethide by Smith Kline & French
(1944)
Source URL:
First approved in 1944
Source:
Furmethide by Smith Kline & French
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
Source:
Furmethide by Smith Kline & French
(1944)
Source URL:
First approved in 1944
Source:
Furmethide by Smith Kline & French
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
Source:
Furmethide by Smith Kline & French
(1944)
Source URL:
First approved in 1944
Source:
Furmethide by Smith Kline & French
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
Source:
Furmethide by Smith Kline & French
(1944)
Source URL:
First approved in 1944
Source:
Furmethide by Smith Kline & French
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
Source:
Furmethide by Smith Kline & French
(1944)
Source URL:
First approved in 1944
Source:
Furmethide by Smith Kline & French
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
First approved in 1944

Class (Stereo):
CHEMICAL (ACHIRAL)


Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid. Aminohippuric acid sodium salt is an agent to measure effective renal plasma flow (ERPF).
Status:
US Previously Marketed
Source:
Furmethide by Smith Kline & French
(1944)
Source URL:
First approved in 1944
Source:
Furmethide by Smith Kline & French
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
Source:
Sulfapyrazine by Mead Johnson
(1944)
Source URL:
First approved in 1944
Source:
Sulfapyrazine by Mead Johnson
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
US Previously Marketed
Source:
Mercuhydrin Sodium by Lakeside (MerrellNational)
(1943)
Source URL:
First approved in 1943
Source:
Mercuhydrin Sodium by Lakeside (MerrellNational)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

MERALLURIDE ACID is an organomercuric compound. It was used as a diuretic in a 1:1 mixture with theophylline.

Showing 158531 - 158540 of 167129 results