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Details

Stereochemistry ACHIRAL
Molecular Formula C8H14NO.I
Molecular Weight 267.1076
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FURTRETHONIUM IODIDE

SMILES

C[N+](C)(C)Cc1ccco1.[I-]

InChI

InChIKey=YKASHPSKFYVZRC-UHFFFAOYSA-M
InChI=1S/C8H14NO.HI/c1-9(2,3)7-8-5-4-6-10-8;/h4-6H,7H2,1-3H3;1H/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula C8H14NO
Molecular Weight 140.2032
Charge 1
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula HI
Molecular Weight 127.9124
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Furmethide

Approved Use

Furtrethonum is a parasympathomimetic drug used for the treatment of glaucoma
Doses

Doses

DosePopulationAdverse events​
10 % 1 times / day multiple, ophthalmic
Dose: 10 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 1 times / day
Sources:
unhealthy
n = 21
Health Status: unhealthy
Condition: glaucoma
Population Size: 21
Sources:
Disc. AE: Dacryostenosis acquired...
AEs leading to
discontinuation/dose reduction:
Dacryostenosis acquired (71%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Dacryostenosis acquired 71%
Disc. AE
10 % 1 times / day multiple, ophthalmic
Dose: 10 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 1 times / day
Sources:
unhealthy
n = 21
Health Status: unhealthy
Condition: glaucoma
Population Size: 21
Sources:
PubMed

PubMed

TitleDatePubMed
Further studies on the use of furmethide in the treatment of glaucoma.
1946 Apr
The use of furmethide in comparison with pilocarpine and eserine for the treatment of glaucoma.
1947 Aug
Glaucoma treatment by furnethide and diisopropylfluorophosphate.
1949 Jul
Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
1997 Jul
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Jun 25 23:27:50 UTC 2021
Edited
by admin
on Fri Jun 25 23:27:50 UTC 2021
Record UNII
1D064NLD7G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FURTRETHONIUM IODIDE
INN   MI  
INN  
Official Name English
FURANOL
Systematic Name English
2-FURANMETHANAMINIUM, N,N,N-TRIMETHYL-, IODIDE
Systematic Name English
FURTRETHONIUM IODIDE [MI]
Common Name English
FURTRETHONIUM IODIDE [INN]
Common Name English
FURFURYLTRIMETHYL AMMONIUM IODIDE
Systematic Name English
2-FURANMETHANAMINIUM, N,N,N-TRIMETHYL-, IODIDE (1:1)
Systematic Name English
TRIMETHYLFURFURYLAMMONIUM IODIDE
Systematic Name English
FURAMON
Brand Name English
FURMETHIDE IODIDE
Brand Name English
NSC-27126
Code English
AMMONIUM, FURFURYLTRIMETHYL-, IODIDE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C47796
Created by admin on Fri Jun 25 23:27:50 UTC 2021 , Edited by admin on Fri Jun 25 23:27:50 UTC 2021
Code System Code Type Description
INN
133
Created by admin on Fri Jun 25 23:27:50 UTC 2021 , Edited by admin on Fri Jun 25 23:27:50 UTC 2021
PRIMARY
FDA UNII
1D064NLD7G
Created by admin on Fri Jun 25 23:27:50 UTC 2021 , Edited by admin on Fri Jun 25 23:27:50 UTC 2021
PRIMARY
ChEMBL
CHEMBL2110739
Created by admin on Fri Jun 25 23:27:50 UTC 2021 , Edited by admin on Fri Jun 25 23:27:50 UTC 2021
PRIMARY
EVMPD
SUB07854MIG
Created by admin on Fri Jun 25 23:27:50 UTC 2021 , Edited by admin on Fri Jun 25 23:27:50 UTC 2021
PRIMARY
CAS
541-64-0
Created by admin on Fri Jun 25 23:27:50 UTC 2021 , Edited by admin on Fri Jun 25 23:27:50 UTC 2021
PRIMARY
MERCK INDEX
M5611
Created by admin on Fri Jun 25 23:27:50 UTC 2021 , Edited by admin on Fri Jun 25 23:27:50 UTC 2021
PRIMARY Merck Index
NCI_THESAURUS
C76041
Created by admin on Fri Jun 25 23:27:50 UTC 2021 , Edited by admin on Fri Jun 25 23:27:50 UTC 2021
PRIMARY
PUBCHEM
10937
Created by admin on Fri Jun 25 23:27:50 UTC 2021 , Edited by admin on Fri Jun 25 23:27:50 UTC 2021
PRIMARY
ECHA (EC/EINECS)
208-789-5
Created by admin on Fri Jun 25 23:27:50 UTC 2021 , Edited by admin on Fri Jun 25 23:27:50 UTC 2021
PRIMARY
MESH
C028530
Created by admin on Fri Jun 25 23:27:50 UTC 2021 , Edited by admin on Fri Jun 25 23:27:50 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY