MERALLURIDE SODIUM

US Previously Marketed

First approved in 1943

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H14HgN2O5.C7H8N4O2.Na.HO
Molecular Weight	650.97
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[OH-].[Na+].CN1C2=C(N=CN2)C(=O)N(C)C1=O.COC(C[Hg+])CNC(=O)NC(=O)CCC([O-])=O

InChI

InChIKey=BDFXZRBRZBBYDN-UHFFFAOYSA-L

InChI=1S/C9H15N2O5.C7H8N4O2.Hg.Na.H2O/c1-6(16-2)5-10-9(15)11-7(12)3-4-8(13)14;1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;;;/h6H,1,3-5H2,2H3,(H,13,14)(H2,10,11,12,15);3H,1-2H3,(H,8,9);;;1H2/q;;2*+1;/p-2

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C7H8N4O2
Molecular Weight	180.164
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C9H14HgN2O5
Molecular Weight	430.81
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugfuture.com/chemdata/meralluride.html | https://www.ncbi.nlm.nih.gov/pubmed/14215515

MERALLURIDE ACID is an organomercuric compound. It was used as a diuretic in a 1:1 mixture with theophylline.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Edema 22 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13706413 https://www.ncbi.nlm.nih.gov/pubmed/14215515 https://www.ncbi.nlm.nih.gov/pubmed/5264344	Primary		Approved 8429	Mercuhydrin Approved Use Meralluride (mercuhydrin®) is an organomercuric compound. It has been used as a diuretic.

Doses

Dose	Population	Adverse events
2 mL 1 times / 2 days multiple, intramuscular Dose: 2 mL, 1 times / 2 days Route: intramuscular Route: multiple Dose: 2 mL, 1 times / 2 days Sources: https://pubmed.ncbi.nlm.nih.gov/5958596	unhealthy n = 11 Health Status: unhealthy Condition: cirrhosis Sex: M+F Population Size: 11 Sources: https://pubmed.ncbi.nlm.nih.gov/5958596	Disc. AE: Encephalopathy... AEs leading to discontinuation/dose reduction: Encephalopathy (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/5958596

AEs

AE	Significance	Dose	Population
Encephalopathy	1 patient Disc. AE	2 mL 1 times / 2 days multiple, intramuscular Dose: 2 mL, 1 times / 2 days Route: intramuscular Route: multiple Dose: 2 mL, 1 times / 2 days Sources: https://pubmed.ncbi.nlm.nih.gov/5958596	unhealthy n = 11 Health Status: unhealthy Condition: cirrhosis Sex: M+F Population Size: 11 Sources: https://pubmed.ncbi.nlm.nih.gov/5958596

Sourcing

Vendor/Aggregator	ID	URL
ChemIDplus	769856679	https://chem.nlm.nih.gov/chemidplus/id/0769856679
PubChem	122129928	https://pubchem.ncbi.nlm.nih.gov/compound/122129928
Wikidata	Q27287596

PubMed

Title	Date	PubMed
Comparison of hydroflumethiazide and meralluride. New method for quantitative assay of diuretics in bedfast patients with edema.	1961 Jul 29	13706413
DIURETIC EFFECT OF POLYTHIAZIDE AND SODIUM MERALLURIDE. COMPARISON IN BEDFAST PATIENTS WITH EDEMA.	1964 Nov 16	14215515
Relative diuretic potential of intramuscular meralluride and oral hydrochlorothiazide in patients with edema.	1970 Mar-Apr	5264344

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:55:25 GMT 2023` Edited by `admin` on `Sat Dec 16 17:55:25 GMT 2023`
Record UNII	3P7B4Q5T8A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MERALLURIDE SODIUM

Common Name

English

SODIUM MERALLURIDE

Common Name

English

MERCUHYDRIN

Brand Name

English

Meralluride sodium [WHO-DD]

Common Name

English

meralluride [INN]

Common Name

English

1:1 MIXTURE OF SODIUM N-((3-(HYDROXYMERCURI)-2-METHOXYPROPYL)CARBAMOYL)SUCCINATE AND THEOPHYLLINE

Common Name

English

MERCURATE(1-), (3-((((3-CARBOXYLATO-1-OXOPROPYL)AMINO)CARBONYL-.KAPPA.O)AMINO)-2-METHOXYPROPYL-.KAPPA.C)HYDROXY-, SODIUM (1:1), MIXT. WITH 3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE

Systematic Name

English

NSC-19909

Code

English

MERALLURIDE [MI]

Common Name

English

MERALLURIDE

Official Name

English

MERCURETIN

Systematic Name

English

Code System Code Type Description

NCI_THESAURUS

C166688