MERALLURIDE SODIUM

US Previously Marketed

First approved in 1943

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H14HgN2O5.C7H8N4O2.Na.HO
Molecular Weight	650.97
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[OH-].[Na+].CN1C2=C(N=CN2)C(=O)N(C)C1=O.COC(C[Hg+])CNC(=O)NC(=O)CCC([O-])=O

InChI

InChIKey=BDFXZRBRZBBYDN-UHFFFAOYSA-L

InChI=1S/C9H15N2O5.C7H8N4O2.Hg.Na.H2O/c1-6(16-2)5-10-9(15)11-7(12)3-4-8(13)14;1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;;;/h6H,1,3-5H2,2H3,(H,13,14)(H2,10,11,12,15);3H,1-2H3,(H,8,9);;;1H2/q;;2*+1;/p-2

HIDE SMILES / InChI

Molecular Formula	C7H8N4O2
Molecular Weight	180.164
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C9H14HgN2O5
Molecular Weight	430.81
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.drugfuture.com/chemdata/meralluride.html | https://www.ncbi.nlm.nih.gov/pubmed/14215515

MERALLURIDE ACID is an organomercuric compound. It was used as a diuretic in a 1:1 mixture with theophylline.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Edema 23 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13706413 https://www.ncbi.nlm.nih.gov/pubmed/14215515 https://www.ncbi.nlm.nih.gov/pubmed/5264344	Primary		Approved 8583	Mercuhydrin Approved Use Meralluride (mercuhydrin®) is an organomercuric compound. It has been used as a diuretic.

Doses

Dose	Population	Adverse events
2 mL 1 times / 2 days multiple, intramuscular Dose: 2 mL, 1 times / 2 days Route: intramuscular Route: multiple Dose: 2 mL, 1 times / 2 days Sources: https://pubmed.ncbi.nlm.nih.gov/5958596	unhealthy Health Status: unhealthy Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/5958596	Disc. AE: Encephalopathy... AEs leading to discontinuation/dose reduction: Encephalopathy (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/5958596

AEs

AE	Significance	Dose	Population
Encephalopathy	1 patient Disc. AE	2 mL 1 times / 2 days multiple, intramuscular Dose: 2 mL, 1 times / 2 days Route: intramuscular Route: multiple Dose: 2 mL, 1 times / 2 days Sources: https://pubmed.ncbi.nlm.nih.gov/5958596	unhealthy Health Status: unhealthy Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/5958596

Sourcing

Vendor/Aggregator	ID	URL
ChemIDplus	769856679	https://chem.nlm.nih.gov/chemidplus/id/0769856679
PubChem	122129928	https://pubchem.ncbi.nlm.nih.gov/compound/122129928
Wikidata	Q27287596

PubMed

Title	Date	PubMed
Relative diuretic potential of intramuscular meralluride and oral hydrochlorothiazide in patients with edema.	1970-03-01	5264344
DIURETIC EFFECT OF POLYTHIAZIDE AND SODIUM MERALLURIDE. COMPARISON IN BEDFAST PATIENTS WITH EDEMA.	1964-11-16	14215515
Comparison of hydroflumethiazide and meralluride. New method for quantitative assay of diuretics in bedfast patients with edema.	1961-07-29	13706413

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:46:39 GMT 2025` Edited by `admin` on `Wed Apr 02 09:46:39 GMT 2025`
Record UNII	3P7B4Q5T8A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MERALLURIDE SODIUM

Common Name

English

MERALLURIDE

Preferred Name

English

SODIUM MERALLURIDE

Common Name

English

MERCUHYDRIN

Brand Name

English

Meralluride sodium [WHO-DD]

Common Name

English

meralluride [INN]

Common Name

English

1:1 MIXTURE OF SODIUM N-((3-(HYDROXYMERCURI)-2-METHOXYPROPYL)CARBAMOYL)SUCCINATE AND THEOPHYLLINE

Common Name

English

MERCURATE(1-), (3-((((3-CARBOXYLATO-1-OXOPROPYL)AMINO)CARBONYL-.KAPPA.O)AMINO)-2-METHOXYPROPYL-.KAPPA.C)HYDROXY-, SODIUM (1:1), MIXT. WITH 3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE

Systematic Name

English

NSC-19909

Code

English

MERALLURIDE [MI]

Common Name

English

MERCURETIN

Systematic Name

English

Code System Code Type Description

NCI_THESAURUS

C166688