Details
Stereochemistry | RACEMIC |
Molecular Formula | C9H15HgN2O5.C7H8N4O2.HO |
Molecular Weight | 628.99 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[OH-].CN1C2=C(N=CN2)C(=O)N(C)C1=O.COC(C[Hg+])CNC(=O)NC(=O)CCC(O)=O
InChI
InChIKey=JESFLKNCDDOHQY-UHFFFAOYSA-M
InChI=1S/C9H15N2O5.C7H8N4O2.Hg.H2O/c1-6(16-2)5-10-9(15)11-7(12)3-4-8(13)14;1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;;/h6H,1,3-5H2,2H3,(H,13,14)(H2,10,11,12,15);3H,1-2H3,(H,8,9);;1H2/q;;+1;/p-1
Molecular Formula | HO |
Molecular Weight | 17.0073 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C9H15HgN2O5 |
Molecular Weight | 431.82 |
Charge | 1 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Molecular Formula | C7H8N4O2 |
Molecular Weight | 180.164 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Doses
Dose | Population | Adverse events |
---|---|---|
2 mL 1 times / 2 days multiple, intramuscular Dose: 2 mL, 1 times / 2 days Route: intramuscular Route: multiple Dose: 2 mL, 1 times / 2 days Sources: |
unhealthy n = 11 Health Status: unhealthy Condition: cirrhosis Sex: M+F Population Size: 11 Sources: |
Disc. AE: Encephalopathy... AEs leading to discontinuation/dose reduction: Encephalopathy (1 patient) Sources: |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Encephalopathy | 1 patient Disc. AE |
2 mL 1 times / 2 days multiple, intramuscular Dose: 2 mL, 1 times / 2 days Route: intramuscular Route: multiple Dose: 2 mL, 1 times / 2 days Sources: |
unhealthy n = 11 Health Status: unhealthy Condition: cirrhosis Sex: M+F Population Size: 11 Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
Comparison of hydroflumethiazide and meralluride. New method for quantitative assay of diuretics in bedfast patients with edema. | 1961 Jul 29 |
|
DIURETIC EFFECT OF POLYTHIAZIDE AND SODIUM MERALLURIDE. COMPARISON IN BEDFAST PATIENTS WITH EDEMA. | 1964 Nov 16 |
|
Relative diuretic potential of intramuscular meralluride and oral hydrochlorothiazide in patients with edema. | 1970 Mar-Apr |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:09:45 GMT 2023
by
admin
on
Fri Dec 15 15:09:45 GMT 2023
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Record UNII |
R062D0212H
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Record Status |
Validated (UNII)
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Record Version |
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-
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MERALLURIDE
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100000076543
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769856-67-9
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DTXSID701334243
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R062D0212H
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122129928
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admin on Fri Dec 15 15:09:45 GMT 2023 , Edited by admin on Fri Dec 15 15:09:45 GMT 2023
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PRIMARY |
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SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
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ACTIVE MOIETY |