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Details

Stereochemistry ACHIRAL
Molecular Formula C8H14NO.C7H7O3S
Molecular Weight 311.397
Optical Activity NONE
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FURTRETHONIUM TOSYLATE

SMILES

C[N+](C)(C)CC1=CC=CO1.CC2=CC=C(C=C2)S([O-])(=O)=O

InChI

InChIKey=QUAGBPHWBBENAF-UHFFFAOYSA-M
InChI=1S/C8H14NO.C7H8O3S/c1-9(2,3)7-8-5-4-6-10-8;1-6-2-4-7(5-3-6)11(8,9)10/h4-6H,7H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

HIDE SMILES / InChI
FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Furmethide

Approved Use

Furtrethonum is a parasympathomimetic drug used for the treatment of glaucoma
Doses

Doses

DosePopulationAdverse events​
10 % 1 times / day multiple, ophthalmic
Dose: 10 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Disc. AE: Dacryostenosis acquired...
AEs leading to
discontinuation/dose reduction:
Dacryostenosis acquired (71%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Dacryostenosis acquired 71%
Disc. AE
10 % 1 times / day multiple, ophthalmic
Dose: 10 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
PubMed

PubMed

TitleDatePubMed
Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
1997-07
Glaucoma treatment by furnethide and diisopropylfluorophosphate.
1949-07
The use of furmethide in comparison with pilocarpine and eserine for the treatment of glaucoma.
1947-08
Further studies on the use of furmethide in the treatment of glaucoma.
1946-04
Patents

Patents

Name Type Language
FURTRETHONIUM P-TOLUENESULFONATE
MI  
Preferred Name English
FURTRETHONIUM TOSYLATE
Common Name English
UCEPHA-11001
Code English
TRIMETHYLFURFURYLAMMONIUM P-TOLUENESULFONATE
Common Name English
AMMONIUM, FURFURYLTRIMETHYL-, P-TOLUENESULFONATE
Common Name English
FISOSTINA
Brand Name English
FURTRETHONIUM P-TOLUENESULFONATE [MI]
Common Name English
FURFURYLTRIMETHYLAMMONIUM P-TOLUENESULFONATE
Common Name English
2-FURANMETHANAMINIUM, N,N,N-TRIMETHYL-, SALT WITH 4-METHYLBENZENESULFONIC ACID (1:1)
Systematic Name English
FURTRETHONIUM TOSILATE
Common Name English
2-FURANMETHANAMINIUM, N,N,N-TRIMETHYL-, 4-METHYLBENZENESULFONATE (1:1)
Systematic Name English
Code System Code Type Description
MERCK INDEX
m5611
Created by admin on Mon Mar 31 23:37:18 GMT 2025 , Edited by admin on Mon Mar 31 23:37:18 GMT 2025
PRIMARY
FDA UNII
15H5ION32Q
Created by admin on Mon Mar 31 23:37:18 GMT 2025 , Edited by admin on Mon Mar 31 23:37:18 GMT 2025
PRIMARY
PUBCHEM
20056781
Created by admin on Mon Mar 31 23:37:18 GMT 2025 , Edited by admin on Mon Mar 31 23:37:18 GMT 2025
PRIMARY
CAS
5978-73-4
Created by admin on Mon Mar 31 23:37:18 GMT 2025 , Edited by admin on Mon Mar 31 23:37:18 GMT 2025
PRIMARY