AMINOHIPPURATE SODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H9N2O3.Na
Molecular Weight	216.1691
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

[Na+].NC1=CC=C(C=C1)C(=O)NCC([O-])=O

InChI

InChIKey=UNZMYCAEMNVPHX-UHFFFAOYSA-M

InChI=1S/C9H10N2O3.Na/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13;/h1-4H,5,10H2,(H,11,14)(H,12,13);/q;+1/p-1

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Description

Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid. Aminohippuric acid sodium salt is an agent to measure effective renal plasma flow (ERPF).

CNS Activity

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Renal function tests 2	Diagnostic		Approved 8,429	AMINOHIPPURATE SODIUM

C_max

Value	Dose	Co-administered	Analyte	Population
250 μg/mL	30 mg/kg single, intravenous		AMINOHIPPURIC ACID plasma	Rattus norvegicus

AUC

Value	Dose	Co-administered	Analyte	Population
880 μg × min/mL	30 mg/kg single, intravenous		AMINOHIPPURIC ACID plasma	Rattus norvegicus

T_1/2

Value	Dose	Co-administered	Analyte	Population
5.67 min	30 mg/kg single, intravenous		AMINOHIPPURIC ACID plasma	Rattus norvegicus

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
OAT1 599 OAT3 642	OAT1 326 MRP1 107 MRP2 205 MRP4 77 OAT3 339

Drug as perpetrator

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Target	Modality	Activity	Metabolite	Clinical evidence
OAT1 603	inhibitor 3,277	yes [IC50 8.8 uM]		yes (co-administration study)
OAT3 644	inhibitor 3,277	yes [Ki 19.6 uM]		yes (co-administration study)

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Drug as victim

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Target	Modality	Activity
MRP1 107	substrate 3,367	yes
MRP2 205	substrate 3,367	yes
MRP4 77	substrate 3,367	yes
OAT1 326	substrate 3,367	yes
OAT3 339	substrate 3,367	yes

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
001 Chemical	DY443883	https://www.001chemical.com/chem/61-78-9
3B Scientific (Wuhan) Corp	3B3-011351	http://www.3bsc.com/index/pro_info.php?id=33850
AA Blocks	AA00E8TT	http://www.aablocks.com/goods/Goods/detail?id=AA00E8TT
AHH Chemical co.,ltd	MT-41082	http://www.ahhchemical.com/product/MT-41082.html
AK Scientific, Inc. (AKSCI)	X6859	http://www.aksci.com/item_detail.php?cat=X6859

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PubMed

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Title	Date	PubMed
Biodistribution and renal excretion of isomers of the cationic tracer, (99m)Tc diaminocyclohexane (DACH): biodistribution of cationic renal tracers.	2001 Apr	11323241
Assessment of postabsorptive renal glucose metabolism in humans with multiple glucose tracers.	2001 Apr	11289038
Losartan may modulate erythropoietin production.	2001 Dec	11881132
Sodium and water homeostasis in children with shigellosis.	2001 Dec	11853332
Progress in understanding human ischemic acute renal failure.	2001 Feb	11157390

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Patents

Sample Use Guides

In Vivo Use Guide

6 to 10 mg/kg

Route of Administration: Intravenous

In Vitro Use Guide

The hOAT1-transformed cells were incubated in 200 ml of Dulbecco's PBS containing 5 mM D-glucose, 10 uM D-[3H]-mannitol and 10 uM [14C]-aminohippuric acid, for 10 min at room temperature.

Show entries

Name

Type

Language

AMINOHIPPURATE SODIUM

Systematic Name

English

AMINOHIPPURATE

Systematic Name

English

SODIUM P-AMINOHIPPURATE [JAN]

Common Name

English

.RHO.-AMINOHIPPURIC ACID SODIUM SALT [MI]

Common Name

English

Aminohippurate sodium [WHO-DD]

Common Name

English

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Classification Tree

Code System

Code

Reagent

NCI_THESAURUS

C1937

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Code System

Code

Type

Description

RXCUI

42837

ALTERNATIVE

RXCUI

203194

PRIMARY

CAS

94-16-6

PRIMARY

PUBCHEM

443971

PRIMARY

CHEBI

64703

PRIMARY

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ACTIVE MOIETY


					Y79XT83BJ9

AMINOHIPPURIC ACID

SUBSTANCE RECORD


					SUO3KVS1O9

AMINOHIPPURATE SODIUM

SMILES

InChI

CNS Activity

Approval Year

Conditions

Cmax

AUC

T1/2

Overview

OverviewOther

Drug as perpetrator​

Drug as victim

Sourcing

PubMed

Patents

Sample Use Guides

C_max

T_1/2

Drug as perpetrator