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Details

Stereochemistry ACHIRAL
Molecular Formula C8H14NO.C6H5O3S
Molecular Weight 297.37
Optical Activity NONE
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FURTRETHONIUM BESYLATE

SMILES

C[N+](C)(C)CC1=CC=CO1.[O-]S(=O)(=O)C2=CC=CC=C2

InChI

InChIKey=IVNIBHOEODRCPK-UHFFFAOYSA-M
InChI=1S/C8H14NO.C6H6O3S/c1-9(2,3)7-8-5-4-6-10-8;7-10(8,9)6-4-2-1-3-5-6/h4-6H,7H2,1-3H3;1-5H,(H,7,8,9)/q+1;/p-1

HIDE SMILES / InChI
FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Furmethide

Approved Use

Furtrethonum is a parasympathomimetic drug used for the treatment of glaucoma
Doses

Doses

DosePopulationAdverse events​
10 % 1 times / day multiple, ophthalmic
Dose: 10 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Disc. AE: Dacryostenosis acquired...
AEs leading to
discontinuation/dose reduction:
Dacryostenosis acquired (71%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Dacryostenosis acquired 71%
Disc. AE
10 % 1 times / day multiple, ophthalmic
Dose: 10 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
PubMed

PubMed

TitleDatePubMed
Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
1997-07
Glaucoma treatment by furnethide and diisopropylfluorophosphate.
1949-07
The use of furmethide in comparison with pilocarpine and eserine for the treatment of glaucoma.
1947-08
Further studies on the use of furmethide in the treatment of glaucoma.
1946-04
Patents

Patents

Name Type Language
FURTRETHONIUM BESYLATE
Common Name English
FURTRETHONIUM BENZENESULFONATE
MI  
Preferred Name English
FURTRETHONIUM BENZENESULFONATE [MI]
Common Name English
BENZAMON
Brand Name English
FURFURYLTRIMETHYLAMMONIUM BENZENESULFONATE
Systematic Name English
2-FURANMETHANAMINIUM, N,N,N-TRIMETHYL-, BENZENESULFONATE (1:1)
Systematic Name English
TRIMETHYLFURFURYLAMMONIUM BENZENESULFONATE
Systematic Name English
FURTRETHONIUM BESILATE
Common Name English
2-FURANMETHANAMINIUM, N,N,N-TRIMETHYL-, BENZENESULFONATE
Systematic Name English
Code System Code Type Description
MERCK INDEX
m5611
Created by admin on Mon Mar 31 22:31:02 GMT 2025 , Edited by admin on Mon Mar 31 22:31:02 GMT 2025
PRIMARY
FDA UNII
EGN9KOM72T
Created by admin on Mon Mar 31 22:31:02 GMT 2025 , Edited by admin on Mon Mar 31 22:31:02 GMT 2025
PRIMARY
CAS
3481-26-3
Created by admin on Mon Mar 31 22:31:02 GMT 2025 , Edited by admin on Mon Mar 31 22:31:02 GMT 2025
PRIMARY
PUBCHEM
15692623
Created by admin on Mon Mar 31 22:31:02 GMT 2025 , Edited by admin on Mon Mar 31 22:31:02 GMT 2025
PRIMARY