Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H14NO.Cl |
| Molecular Weight | 175.656 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].C[N+](C)(C)CC1=CC=CO1
InChI
InChIKey=ZZYOCRDJISDSSY-UHFFFAOYSA-M
InChI=1S/C8H14NO.ClH/c1-9(2,3)7-8-5-4-6-10-8;/h4-6H,7H2,1-3H3;1H/q+1;/p-1
| Molecular Formula | C8H14NO |
| Molecular Weight | 140.2029 |
| Charge | 1 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Doses
| Dose | Population | Adverse events |
|---|---|---|
10 % 1 times / day multiple, ophthalmic Dose: 10 %, 1 times / day Route: ophthalmic Route: multiple Dose: 10 %, 1 times / day Sources: |
unhealthy n = 21 Health Status: unhealthy Condition: glaucoma Population Size: 21 Sources: |
Disc. AE: Dacryostenosis acquired... AEs leading to discontinuation/dose reduction: Dacryostenosis acquired (71%) Sources: |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Dacryostenosis acquired | 71% Disc. AE |
10 % 1 times / day multiple, ophthalmic Dose: 10 %, 1 times / day Route: ophthalmic Route: multiple Dose: 10 %, 1 times / day Sources: |
unhealthy n = 21 Health Status: unhealthy Condition: glaucoma Population Size: 21 Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Further studies on the use of furmethide in the treatment of glaucoma. | 1946 Apr |
|
| The use of furmethide in comparison with pilocarpine and eserine for the treatment of glaucoma. | 1947 Aug |
|
| Glaucoma treatment by furnethide and diisopropylfluorophosphate. | 1949 Jul |
|
| Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. | 1997 Jul |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 18:17:53 GMT 2023
by
admin
on
Sat Dec 16 18:17:53 GMT 2023
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| Record UNII |
C8YL6NCP1Y
|
| Record Status |
Validated (UNII)
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| Record Version |
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119026039
Created by
admin on Sat Dec 16 18:17:53 GMT 2023 , Edited by admin on Sat Dec 16 18:17:53 GMT 2023
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6035-90-1
Created by
admin on Sat Dec 16 18:17:53 GMT 2023 , Edited by admin on Sat Dec 16 18:17:53 GMT 2023
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C8YL6NCP1Y
Created by
admin on Sat Dec 16 18:17:53 GMT 2023 , Edited by admin on Sat Dec 16 18:17:53 GMT 2023
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PRIMARY |
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|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |