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Restrict the search for
methyl salicylate
to a specific field?
Status:
Investigational
Source:
INN:peliglitazar [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Peliglitazar (also known as BMS 426707-01), a dual α/γ peroxisome proliferator-activated receptor agonist, has been studied in phase I/II clinical trial in patients with type 2 diabetes mellitus. However, this study was discontinued.
Status:
Investigational
Source:
INN:clotixamide [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Clothixamide is a dopamine antagonist. The compound was invented by Pfizer in the 1960s and is claimed to be useful for the chemotherapy of mental diseases and especially for the control of excited states. Also, clothixamide is claimed to have potent antiemetic properties.
Class (Stereo):
CHEMICAL (ACHIRAL)
Climazolam is a benzodiazepine derivative, developed by Hoffman-LaRoche. It was used in veterinary for anesthetizing animals.
Status:
Investigational
Source:
JAN:INAPERISONE HYDROCHLORIDE [JAN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Inaperisone is a pyrrolidinopropiophenone derivative patented by Japanese pharmaceutical company Hokuriku Pharmaceutical Co. as muscle-relaxant and antispasmodic agent.
Status:
Investigational
Source:
NCT04575038: Phase 2 Interventional Completed COVID-19 Infection
(2020)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Brequinar is a synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. Brequinar had been in phase II clinical trials by Bristol-Myers Squibb for the treatment of cancer and transplant rejection. However, this research has been discontinued.
Brequinar had been also in preclinical studys for the treatment of cytomegalovirus infections. However, this research has been discontinued.
Status:
Investigational
Source:
NCT03765801: Phase 1 Interventional Completed Pain
(2003)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Faxeladol (GRT9906) is a μ-opioid receptor agonist and inhibitor of noradrenalin/serotonin re-uptake. Faxeladol was being studied in the treatment of fibromyalgia and neuropathic pain, however its development has been discontinued.
Class (Stereo):
CHEMICAL (ACHIRAL)
Baquiloprim, a drug that was used in veterinary medicine, e.g. in combination with sulphadimidine for the treatment of diarrhea in calves. However, the drug has vanished from the use mainly for commercial reason.
Status:
Investigational
Source:
NCT00808977: Phase 2 Interventional Completed Ulcerative Colitis
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Dersalazine is a locally-acting compound. It is a potent platelet activating factor (PAF)-antagonist. Dersalazine inhibited IL-1beta or TNF-alpha production in THP-1 or U937 cells, respectively. Dersalazine sodium reduced colonic proinflammatory cytokines IL-1b, IL-6, and IL-17 in dextran sodium sulphate (DSS)–induced colitis. After oral administration, dersalazine sodium is mostly unabsorbed until it reaches the large bowel where the azo bond is reduced by bacteria releasing the active compound. Dersalazine had been in phase I clinical trial for the treatment of ulcerative colitis. No serious adverse reactions were detected in clinical trial. However, no recent development has been reported.
Status:
Investigational
Class (Stereo):
CHEMICAL (MIXED)
Pyroxamine (also known as AHR 224) is benzhydryl ethers of 3-pyrrolidinol patented by A. H. Robins Co., Inc. as antihistamine with bronchodilation activity. In preclinical studies, Pyroxamine shows moderate inhibition of histamine-induced ulceration in guinea pigs
Class (Stereo):
CHEMICAL (ABSOLUTE)
Galdansetron is a selective serotonin antagonist compound that is effective against vomiting and nausea. This type of drug is used to treat motion sickness or side effects of chemotherapy or anesthetics.
