PYROXAMINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	MIXED
Molecular Formula	C18H20ClNO
Molecular Weight	301.811
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PYROXAMINE

Structure Search

SMILES

CN1CCC(C1)OC(C2=CC=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=CMARNPIDSNAMJM-UHFFFAOYSA-N

InChI=1S/C18H20ClNO/c1-20-12-11-17(13-20)21-18(14-5-3-2-4-6-14)15-7-9-16(19)10-8-15/h2-10,17-18H,11-13H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13655030 | https://www.ncbi.nlm.nih.gov/pubmed/13776501

Pyroxamine (also known as AHR 224) is benzhydryl ethers of 3-pyrrolidinol patented by A. H. Robins Co., Inc. as antihistamine with bronchodilation activity. In preclinical studies, Pyroxamine shows moderate inhibition of histamine-induced ulceration in guinea pigs

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
Pyroxamine: a clinical study of a new antihistamine.	1961 Jul	13776501

Patents

Patents

Sample Use Guides

In Vivo Use Guide

guinea pig: 1.1 mg/kg

Route of Administration: Other

Name

Type

Language

PYROXAMINE

Official Name

English

3-((P-CHLORO-A-PHENYLBENZYL)OXY)-1-METHYLPYRROLIDINE

Common Name

English

pyroxamine [INN]

Common Name

English

PYRROLIDINE, 3-((4-CHLOROPHENYL)PHENYLMETHOXY)-1-METHYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578

Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023

Code System Code Type Description

ChEMBL

CHEMBL336542

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PUBCHEM

201848

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CAS

7009-68-9

Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023

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INN

1040

Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023

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EPA CompTox

DTXSID30863988

Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023

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WIKIPEDIA

Pyroxamine

Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023

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SMS_ID

100000080872

Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023

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FDA UNII

V1TGZ00I8U

Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023

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NCI_THESAURUS

C84129

Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023

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EVMPD

SUB10178MIG

Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023

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ACTIVE MOIETY


					V1TGZ00I8U

SALT/SOLVATE (PARENT)


					T38B9T1F30

PYROXAMINE MALEATE