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Details

Stereochemistry MIXED
Molecular Formula C18H20ClNO
Molecular Weight 301.811
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PYROXAMINE

SMILES

CN1CCC(C1)OC(C2=CC=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=CMARNPIDSNAMJM-UHFFFAOYSA-N
InChI=1S/C18H20ClNO/c1-20-12-11-17(13-20)21-18(14-5-3-2-4-6-14)15-7-9-16(19)10-8-15/h2-10,17-18H,11-13H2,1H3

HIDE SMILES / InChI
Pyroxamine (also known as AHR 224) is benzhydryl ethers of 3-pyrrolidinol patented by A. H. Robins Co., Inc. as antihistamine with bronchodilation activity. In preclinical studies, Pyroxamine shows moderate inhibition of histamine-induced ulceration in guinea pigs

Approval Year

PubMed

PubMed

TitleDatePubMed
Pyroxamine: a clinical study of a new antihistamine.
1961 Jul
Patents

Sample Use Guides

guinea pig: 1.1 mg/kg
Route of Administration: Other
Name Type Language
PYROXAMINE
INN  
INN  
Official Name English
3-((P-CHLORO-A-PHENYLBENZYL)OXY)-1-METHYLPYRROLIDINE
Common Name English
pyroxamine [INN]
Common Name English
PYRROLIDINE, 3-((4-CHLOROPHENYL)PHENYLMETHOXY)-1-METHYL-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29578
Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL336542
Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023
PRIMARY
PUBCHEM
201848
Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023
PRIMARY
CAS
7009-68-9
Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023
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INN
1040
Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023
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EPA CompTox
DTXSID30863988
Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023
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WIKIPEDIA
Pyroxamine
Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023
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SMS_ID
100000080872
Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023
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FDA UNII
V1TGZ00I8U
Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023
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NCI_THESAURUS
C84129
Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023
PRIMARY
EVMPD
SUB10178MIG
Created by admin on Sat Dec 16 16:50:48 GMT 2023 , Edited by admin on Sat Dec 16 16:50:48 GMT 2023
PRIMARY