PYROXAMINE MALEATE

Details

Stereochemistry	MIXED
Molecular Formula	C18H20ClNO.C4H4O4
Molecular Weight	417.883
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.CN1CCC(C1)OC(C2=CC=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=SIVIYOJJUYSAGX-BTJKTKAUSA-N

InChI=1S/C18H20ClNO.C4H4O4/c1-20-12-11-17(13-20)21-18(14-5-3-2-4-6-14)15-7-9-16(19)10-8-15;5-3(6)1-2-4(7)8/h2-10,17-18H,11-13H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula	C18H20ClNO
Molecular Weight	301.811
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13655030 | https://www.ncbi.nlm.nih.gov/pubmed/13776501

Pyroxamine (also known as AHR 224) is benzhydryl ethers of 3-pyrrolidinol patented by A. H. Robins Co., Inc. as antihistamine with bronchodilation activity. In preclinical studies, Pyroxamine shows moderate inhibition of histamine-induced ulceration in guinea pigs

Originator

Approval Year

PubMed

Title	Date	PubMed
Pyroxamine: a clinical study of a new antihistamine.	1961 Jul	13776501

Patents

Sample Use Guides

In Vivo Use Guide

guinea pig: 1.1 mg/kg

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:27:20 GMT 2023` Edited by `admin` on `Fri Dec 15 16:27:20 GMT 2023`
Record UNII	T38B9T1F30
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PYROXAMINE MALEATE

Official Name

English

PYROXAMINE MALEATE [USAN]

Common Name

English

3-((P-CHLORO-.ALPHA.-PHENYLBENZYL)OXY)-1-METHYLPYRROLIDINE MALEATE (1:1)

Common Name

English

NSC-64540

Code

English

AHR-224

Code

English

PYRROLIDINE, 3-((4-CHLOROPHENYL)PHENYLMETHOXY)-1-METHYL-, (Z)-2-BUTENEDIOATE (1:1)

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578