PYROXAMINE

Details

Stereochemistry	MIXED
Molecular Formula	C18H20ClNO
Molecular Weight	301.811
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC(C1)OC(C2=CC=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=CMARNPIDSNAMJM-UHFFFAOYSA-N

InChI=1S/C18H20ClNO/c1-20-12-11-17(13-20)21-18(14-5-3-2-4-6-14)15-7-9-16(19)10-8-15/h2-10,17-18H,11-13H2,1H3

HIDE SMILES / InChI

Molecular Formula	C18H20ClNO
Molecular Weight	301.811
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13655030 | https://www.ncbi.nlm.nih.gov/pubmed/13776501

Pyroxamine (also known as AHR 224) is benzhydryl ethers of 3-pyrrolidinol patented by A. H. Robins Co., Inc. as antihistamine with bronchodilation activity. In preclinical studies, Pyroxamine shows moderate inhibition of histamine-induced ulceration in guinea pigs

Originator

Approval Year

PubMed

Title	Date	PubMed
Pyroxamine: a clinical study of a new antihistamine.	1961 Jul	13776501

Patents

Sample Use Guides

In Vivo Use Guide

guinea pig: 1.1 mg/kg

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:50:48 GMT 2023` Edited by `admin` on `Sat Dec 16 16:50:48 GMT 2023`
Record UNII	V1TGZ00I8U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PYROXAMINE

Official Name

English

3-((P-CHLORO-A-PHENYLBENZYL)OXY)-1-METHYLPYRROLIDINE

Common Name

English

pyroxamine [INN]

Common Name

English

PYRROLIDINE, 3-((4-CHLOROPHENYL)PHENYLMETHOXY)-1-METHYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578