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Details

Stereochemistry MIXED
Molecular Formula C18H20ClNO
Molecular Weight 301.811
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PYROXAMINE

SMILES

CN1CCC(C1)OC(C2=CC=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=CMARNPIDSNAMJM-UHFFFAOYSA-N
InChI=1S/C18H20ClNO/c1-20-12-11-17(13-20)21-18(14-5-3-2-4-6-14)15-7-9-16(19)10-8-15/h2-10,17-18H,11-13H2,1H3

HIDE SMILES / InChI
Molecular Formula C18H20ClNO
Molecular Weight 301.811
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Pyroxamine (also known as AHR 224) is benzhydryl ethers of 3-pyrrolidinol patented by A. H. Robins Co., Inc. as antihistamine with bronchodilation activity. In preclinical studies, Pyroxamine shows moderate inhibition of histamine-induced ulceration in guinea pigs

Originator

A. H. Robins Co., Inc.
4

Approval Year

Unknown
149,124

PubMed

Patents

20050002865
228
20100226943
186
8158152
108
9016221
110
WO2006014484A2
134

Sample Use Guides

In Vivo Use Guide
guinea pig: 1.1 mg/kg
Route of Administration: Other
Substance Class Chemical
Record UNII
V1TGZ00I8U
Record Status Validated (UNII)
Record Version
NIH
NCATS
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