U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C15H23NO
Molecular Weight 233.3492
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FAXELADOL

SMILES

CN(C)C[C@@H]1CCCC[C@H]1C2=CC(O)=CC=C2

InChI

InChIKey=JIRYWFYYBBRJAN-ZFWWWQNUSA-N
InChI=1S/C15H23NO/c1-16(2)11-13-6-3-4-9-15(13)12-7-5-8-14(17)10-12/h5,7-8,10,13,15,17H,3-4,6,9,11H2,1-2H3/t13-,15-/m0/s1

HIDE SMILES / InChI

Description

Faxeladol (GRT9906) is a μ-opioid receptor agonist and inhibitor of noradrenalin/serotonin re-uptake. Faxeladol was being studied in the treatment of fibromyalgia and neuropathic pain, however its development has been discontinued.

Originator

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Randomized controlled trial of the combined monoaminergic and opioid investigational compound GRT9906 in painful polyneuropathy.
2012-07
Patents

Patents

07884247
2
JP2004527491A
37
JP4737583B2
23

Sample Use Guides

In Vivo Use Guide
During 4-week treatment periods, daily oral doses of faxeladol (GRT9906) 120-240 mg
Route of Administration: Oral
Name Type Language
FAXELADOL
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
EM-906
Preferred Name English
faxeladol [INN]
Common Name English
FAXELADOL [USAN]
Common Name English
GRTA0009906
Code English
GRTA-9906
Code English
GRTA-0009906
Code English
Faxeladol [WHO-DD]
Common Name English
PHENOL, 3-((1R,2R)-2-((DIMETHYLAMINO)METHYL)CYCLOHEXYL)-
Systematic Name English
EM906
Code English
GRT-TA300
Code English
GCR-9905
Code English
3-{(1R,2R)-2-[(Dimethylamino)methyl]cyclohexyl}phenol
Systematic Name English
GCR9905
Code English
GRTA9906
Code English
Code System Code Type Description
EPA CompTox
DTXSID20912318
Created by admin on Wed Apr 02 08:28:51 GMT 2025 , Edited by admin on Wed Apr 02 08:28:51 GMT 2025
PRIMARY
NCI_THESAURUS
C80579
Created by admin on Wed Apr 02 08:28:51 GMT 2025 , Edited by admin on Wed Apr 02 08:28:51 GMT 2025
PRIMARY
SMS_ID
300000034224
Created by admin on Wed Apr 02 08:28:51 GMT 2025 , Edited by admin on Wed Apr 02 08:28:51 GMT 2025
PRIMARY
USAN
UU-170
Created by admin on Wed Apr 02 08:28:51 GMT 2025 , Edited by admin on Wed Apr 02 08:28:51 GMT 2025
PRIMARY
PUBCHEM
9813414
Created by admin on Wed Apr 02 08:28:51 GMT 2025 , Edited by admin on Wed Apr 02 08:28:51 GMT 2025
PRIMARY
FDA UNII
C04V6SGK8H
Created by admin on Wed Apr 02 08:28:51 GMT 2025 , Edited by admin on Wed Apr 02 08:28:51 GMT 2025
PRIMARY
CAS
433265-65-7
Created by admin on Wed Apr 02 08:28:51 GMT 2025 , Edited by admin on Wed Apr 02 08:28:51 GMT 2025
PRIMARY
INN
8787
Created by admin on Wed Apr 02 08:28:51 GMT 2025 , Edited by admin on Wed Apr 02 08:28:51 GMT 2025
PRIMARY
WIKIPEDIA
FAXELADOL
Created by admin on Wed Apr 02 08:28:51 GMT 2025 , Edited by admin on Wed Apr 02 08:28:51 GMT 2025
PRIMARY
ChEMBL
CHEMBL2103829
Created by admin on Wed Apr 02 08:28:51 GMT 2025 , Edited by admin on Wed Apr 02 08:28:51 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of FAXELADOL
SALT/SOLVATE (PARENT)
Structure of FAXELADOL HYDROCHLORIDE
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966