FAXELADOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H23NO
Molecular Weight	233.3492
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)C[C@@H]1CCCC[C@H]1C2=CC(O)=CC=C2

InChI

InChIKey=JIRYWFYYBBRJAN-ZFWWWQNUSA-N

InChI=1S/C15H23NO/c1-16(2)11-13-6-3-4-9-15(13)12-7-5-8-14(17)10-12/h5,7-8,10,13,15,17H,3-4,6,9,11H2,1-2H3/t13-,15-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C15H23NO
Molecular Weight	233.3492
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22337471 | https://www.clinicaltrialsregister.eu/ctr-search/trial/2005-001404-40/DK | https://adisinsight.springer.com/drugs/800032836

Faxeladol (GRT9906) is a μ-opioid receptor agonist and inhibitor of noradrenalin/serotonin re-uptake. Faxeladol was being studied in the treatment of fibromyalgia and neuropathic pain, however its development has been discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Randomized controlled trial of the combined monoaminergic and opioid investigational compound GRT9906 in painful polyneuropathy.	2012 Jul	22337471

Patents

Sample Use Guides

In Vivo Use Guide

During 4-week treatment periods, daily oral doses of faxeladol (GRT9906) 120-240 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:52:18 GMT 2023` Edited by `admin` on `Sat Dec 16 16:52:18 GMT 2023`
Record UNII	C04V6SGK8H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FAXELADOL

Official Name

English

faxeladol [INN]

Common Name

English

FAXELADOL [USAN]

Common Name

English

GRTA0009906

Code

English

GRTA-9906

Code

English

GRTA-0009906

Code

English

Faxeladol [WHO-DD]

Common Name

English

PHENOL, 3-((1R,2R)-2-((DIMETHYLAMINO)METHYL)CYCLOHEXYL)-

Systematic Name

English

EM906

Code

English

EM-906

Code

English

GRT-TA300

Code

English

GCR-9905

Code

English

3-{(1R,2R)-2-[(Dimethylamino)methyl]cyclohexyl}phenol

Systematic Name

English

GCR9905

Code

English

GRTA9906

Code

English

Code System Code Type Description

EPA CompTox

DTXSID20912318