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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 18:29:43 GMT 2025
Edited
by admin
on Tue Apr 01 18:29:43 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
1PE72K8X46
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MU-TYPE OPIOID RECEPTOR
Common Name English
HMOP
Preferred Name English
MU OPIOID RECEPTOR
Common Name English
M-OR-1
Common Name English
MOR1
Common Name English
MOP
Common Name English
hMOP
Common Name English
mu (MOP)
Common Name English
MOR-1
Common Name English
MU OPIATE RECEPTOR
Common Name English
Code System Code Type Description
UNIPROT
P35372
Created by admin on Tue Apr 01 18:29:43 GMT 2025 , Edited by admin on Tue Apr 01 18:29:43 GMT 2025
PRIMARY
FDA UNII
1PE72K8X46
Created by admin on Tue Apr 01 18:29:43 GMT 2025 , Edited by admin on Tue Apr 01 18:29:43 GMT 2025
PRIMARY
From To
1_142 1_219
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_9
N 1_12
N 1_33
N 1_40
N 1_48
Related Record Type Details
Structure of ETODESNITAZENE PHENYLTHIOL ANALOGUE
AGONIST -> TARGET
POTENCY
Structure of THIAFENTANIL
AGONIST -> TARGET
Structure of Methylnitazene
AGONIST -> TARGET
POTENCY
Structure of meta-Fluoro valeryl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of 4'-HYDROXYLNITAZENE
AGONIST -> TARGET
Emax = 81% of Fentanyl
EC50
Structure of N-PHENYLPROPYLNORFENTANYL
AGONIST -> TARGET
Structure of NALDEMEDINE 6-O-.BETA.-D-GLUCURONIDE
INHIBITOR -> TARGET
Structure of Buprenorphine
PARTIAL AGONIST->TARGET
[35S]GTP?S Binding, 28.7 +/- 1.1 simulation
EC50
Structure of OLICERIDINE
AGONIST -> TARGET
Structure of N,N-didesmethyl U-47700
AGONIST -> TARGET
Assumed from being on CDC list
Structure of TILIDINE
WEAK AGONIST->TARGET
Inhibition of forskolin-induced cAMP accumulation
IC50
Structure of BEVENOPRAN
INHIBITOR -> TARGET
PHENARIDINE
AGONIST -> TARGET
Structure of GSK-1521498
INVERSE AGONIST->TARGET
Ki
Structure of N-(2C-C) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ISOBUTYRYLFENTANYL
AGONIST -> TARGET
Structure of 3'-methyl Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of Thiophene fentanyl 3-thiophenecarboxamide
AGONIST -> TARGET
Assumed from being on CDC list
Structure of CYCLOPROPYL FENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of 7-HYDROXYMITRAGYNINE
AGONIST -> TARGET
Reported to have 13X the potency of morphine
Ki
Structure of U-49900
AGONIST -> TARGET
Structure of PHENYLFENTANYL
AGONIST -> TARGET
Structure of ortho-methoxy Butyryl fentanyl
AGONIST -> TARGET
Assumed activity
Structure of AMDAKEFALIN
AGONIST -> TARGET
Structure of N-(DOBU) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of PYRIDIN-4-YLETHYL-NORFENTANYL
AGONIST -> TARGET
Structure of ETODESNITAZENE PYRROLIDINE ANALOGUE
AGONIST -> TARGET
POTENCY
Structure of N-(2C-T-2) fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of PIPERIDYLTHIAMBUTENE
AGONIST -> TARGET
An opioid analgesic drug from the thiambutene family, which has around the same potency as morphine.
Structure of 2',3'-dimethoxy Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of PSICOFENTANIL
AGONIST -> TARGET
Structure of ACRYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of 2,2,3,3-tetramethyl-Cyclopropyl fentanyl
AGONIST -> TARGET
Structure of 2'-methyl Acetyl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of DIPRENORPHINE
INHIBITOR -> TARGET
In contrast to naloxone, diprenorphine (0.03 mgkg?1i.p.)reversed equipotent doses of morphine and fentanyl to the same degree. Assay done on SH-SY5Y cells displacing [3H]DIPRENORPHINE.
Ki
Structure of 2',4'-Dimethoxy fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of U-50488
LIGAND->TARGET
BINDING
IC50
Structure of BETA-METHYL ACETYL FENTANYL
AGONIST -> TARGET
Structure of Thienyl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of METHADONE
AGONIST -> TARGET
Structure of DAMGO H-3
RADIOLIGAND->TARGET
Kd
Structure of FAXELADOL
AGONIST -> TARGET
Structure of Protonitazene
AGONIST -> TARGET
Mini Gi assay. Emax=129 (123-136) relative to Fentanyl. EC50 for Fentanyl=34.6
EC50
Structure of ISOFENTANYL
AGONIST -> TARGET
Assumed from being on CDC list
Structure of 3-PHENYLPROPANOYLFENTANYL
AGONIST -> TARGET
Structure of meta-Fluoro Acrylfentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of N-(2C-iP) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of BUTYRFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of MITRAGYNINE
AGONIST -> TARGET
Structure of MORPHINE
AGONIST -> TARGET
Ki
Structure of LEVORPHANOL
AGONIST -> TARGET
Ki
Structure of LEVOMETHADONE
AGONIST -> TARGET
Male, Wistar rats
Ki
Structure of 3,4-Ethylenedioxy U-47700
AGONIST -> TARGET
Assumed from being on CDC list
Structure of CYCLOBUTYLFENTANYL
AGONIST -> TARGET
EC50
Structure of N-(DOC) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of DIHYDROMORPHINE
AGONIST -> TARGET
Structure of 3,4-Ethylenedioxy U-51754
AGONIST -> TARGET
Assumed from being on CDC list
Structure of N-(2C-B) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ortho-fluoro Valeryl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ORTHO-FLUORO ACRYLFENTANYL
AGONIST -> TARGET
EC50
Structure of META-FLUOROFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of OCFENTANIL
AGONIST -> TARGET
Structure of meta-methyl Furanyl fentanyl
AGONIST -> TARGET
Assumed activity
Structure of DERMORPHIN
AGONIST -> TARGET
IC50
Structure of FURANYLETHYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of MT-45
AGONIST -> TARGET
Inhibition of cAMP accumulation
Structure of 2-CHLOROFENTANYL
AGONIST -> TARGET
RAT OPIOD RECEPTOR; POTENCY RELATIVE TO MORPHINE 2.5
AGONIST
IC50
Structure of PARAFLUOROISOBUTYRYLBENZYLFENTANYL
AGONIST -> TARGET
Structure of METHOXYACETYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of 3-Methyl norfentanyl, (±)-cis-
AGONIST -> TARGET
Assumed from being on CDC list
Structure of BETACETYLMETHADOL
AGONIST -> TARGET
Structure of BRORPHINE
AGONIST -> TARGET
Structure of Methylthionitazene
AGONIST -> TARGET
POTENCY
Structure of 2,2'-DIFLUOROFENTANYL
AGONIST -> TARGET
Structure of 2-FURANYLFENTANYL
AGONIST -> TARGET
Blood furanylfentanyl concentrations are expected to be in a range of 1-45 ?g/L in victims of fatal overdosage.[
Structure of N-Benzylfuranylfentanyl
AGONIST -> TARGET
Assumed an agonist
Structure of Despropionyl ortho-fluorofentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of 4-phenyl U-51754
AGONIST -> TARGET
Assumed from being on CDC list
Structure of MP-135
PARTIAL AGONIST->TARGET
Emax = 23% of DAMGO
EC50
Structure of AXELOPRAN
INHIBITOR -> TARGET
Structure of BU-72
AGONIST -> TARGET
Structure of FENTANYL
AGONIST -> TARGET
HUMAN RECEPTOR
AGONIST
Ki
Structure of 2',5'-Dimethoxy 3',4'-dimethyl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ortho-isopropyl Furanyl fentanyl
AGONIST -> TARGET
Structure of 3'-fluoro ortho-Fluorofentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of SAMERIDINE
PARTIAL AGONIST->TARGET
Structure of 4-methyl Fentanyl
AGONIST -> TARGET
Structure of N-(MDA)-FENTANYL
AGONIST -> TARGET
Structure of ortho-methoxy Furanyl fentanyl
AGONIST -> TARGET
Structure of N-(DOET) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ORTHO-FLUOROBUTYRYL FENTANYL
AGONIST -> TARGET
EC50
Structure of BRONITAZENE
AGONIST -> TARGET
POTENCY
Structure of DIPYANONE
AGONIST -> TARGET
Structure of N-(3C-B-FLY) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of REMIFENTANIL
AGONIST -> TARGET
Potency higher than fentanyl (IC50=1.23 NM) fast onset and short duration of action.
IC50
Structure of PARA-METHOXYBUTYRYL FENTANYL
AGONIST -> TARGET
Structure of N-(2C-T) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of Despropionyl 2'-fluoro ortho-Fluorofentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of NALDEMEDINE
INHIBITOR -> TARGET
Structure of 2'-methyl Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of .ALPHA.-METHYL-.BETA.-HYDROXYFENTANYL
AGONIST -> TARGET
Structure of MIRFENTANIL
AGONIST -> TARGET
3-METHYLFENTANYL
AGONIST -> TARGET
Structure of ETONITAZEPIPNE
AGONIST -> TARGET
Structure of EST-73502
AGONIST -> TARGET
Emax=90% Relative maximum effect induced by stimulation with DAMGO. MOR functionality (EC50) measuring cyclic AMP (cAMP) on CHO-K1 cells.
EC50
Structure of Tigloyl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
NFEPP
AGONIST -> TARGET
Structure of BRIFENTANIL
AGONIST -> TARGET
Structure of Ethylthionitazene
AGONIST -> TARGET
POTENCY
Structure of .BETA.-HYDROXYTHIOFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of 2',6'-dimethoxy Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ETODESNITAZENE PHENYLTHIOL/PYRROLIDINE ANALOGUE
AGONIST -> TARGET
POTENCY
Structure of 4-FLUOROISOBUTYRFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of O-METHYL ACETYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of METODESNITAZENE
WEAK AGONIST->TARGET
Structure of ACETYL-.ALPHA.-METHYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of N-(2C-TFM) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of IQMF-4
AGONIST -> TARGET
Ki
Structure of TEGILERIDINE
AGONIST -> TARGET
Structure of TRAMADOL
AGONIST -> TARGET
(+)-isomer
COMPETITIVE INHIBITOR
Ki
Structure of FRAKEFAMIDE
AGONIST -> TARGET
Structure of 4-FLUOROBUTYRFENTANYL
AGONIST -> TARGET
Structure of N-(2C-E) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of R-30490
AGONIST -> TARGET
Structure of CEBRANOPADOL
AGONIST -> TARGET
Structure of METHYLNALTREXONE
INHIBITOR -> TARGET
Cannot cross blood-brain barrier due to positive charge
Structure of N-(6-APB) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
3-METHYLTHIOFENTANYL
AGONIST -> TARGET
Structure of DIHYDROETORPHINE
AGONIST -> TARGET
Ki
Structure of APADOLINE
LIGAND->BINDER
IC50
Structure of 6-ACETYLMORPHINE
AGONIST -> TARGET
Structure of METHADONE
AGONIST -> TARGET
Ki
Structure of DIMETONITAZENE
AGONIST -> TARGET
POTENCY
Structure of ETODESNITAZENE PIPERIDINE ANALOGUE
AGONIST -> TARGET
POTENCY
Structure of 3-METHYLFENTANYL, (3S,4S)-
AGONIST -> TARGET
Mouse hot plate test. 117 times more potent than morphine.
ED50
Structure of PARA-CHLOROISOBUTYRYL FENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of THIOBROMADOL
AGONIST -> TARGET
In mouse hot plate test, the antinociceptive ED50 of C8813 was 11.5 ?g/kg, being 591 times and 3.4 times more potent than morphine and fentanyl respectively.
Ki
Structure of 3-FURANYLFENTANYL
AGONIST -> TARGET
Structure of Diprenorphine H-3
RADIOLIGAND->TARGET
Kd
Structure of 4-HYDROXYBUTYRFENTANYL
AGONIST -> TARGET
Assumed active
Structure of ALVIMOPAN ANHYDROUS
INHIBITOR -> TARGET
Ki
Structure of TAPENTADOL
AGONIST -> TARGET
Structure of .ALPHA.-METHYL-BUTYRFENTANYL
AGONIST -> TARGET
Structure of METODESNITAZENE
AGONIST -> TARGET
POTENCY
Structure of ALFENTANIL
AGONIST -> TARGET
Structure of METHYL-AP-237
AGONIST -> TARGET
Structure of N-(6-APDB) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of .BETA.-METHYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of HERKINORIN
AGONIST -> TARGET
Herkinorin is a ?-opioid agonist with more than 100x higher ?-opioid affinity and 50x lower ?-opioid affinity compared to Salvinorin A.
Structure of MORPHINE-6-GLUCURONIDE
AGONIST -> TARGET
Ratio to morphine 2.3
EC50
Structure of NALOXONE
INHIBITOR -> TARGET
Mu Receptor [3H]DAMGO BINDING INHIBITION
BINDING
Ki
Structure of ITI-333
AGONIST -> TARGET
Structure of N-(2C-N) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of MITRAGYNINE PSEUDOINDOXYL
PARTIAL AGONIST->TARGET
MOR partial agonists with reduced ?-arrestin-2 recruitment in-vitro. 20-fold more potent than morphine at inhibiting contractions and 100-fold more potent than mitragynine.
EC50
Structure of Naltrexone
INHIBITOR -> TARGET
Structure of 3-METHYLFENTANYL, TRANS-
AGONIST -> TARGET
EC50
Structure of NALTALIMIDE
PARTIAL AGONIST->TARGET
Structure of N-(2C-T-7) Fentanyl
AGONIST -> TARGET
Structure of 4-Methyl cyclopropyl fentanyl
AGONIST -> TARGET
BINDING
Ki
Structure of ETORPHINE
AGONIST -> TARGET
3H-DAMGO specific binding to gerbil ccrebellar membranes.
Ki
Structure of DESMETRAMADOL
AGONIST -> TARGET
Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to ?-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in ?-opioid binding.
Structure of Propyl U-47700
AGONIST -> TARGET
Assumed from being on CDC list
Structure of SEMORPHONE
PARTIAL AGONIST->TARGET
Structure of Cyclopentenyl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of .ALPHA.-METHYLFENTANYL
AGONIST -> TARGET
Structure of GPA-3154
PARTIAL AGONIST->TARGET
Structure of VALERYLFENTANYL
AGONIST -> TARGET
Structure of 2F-MT-45
AGONIST -> TARGET
The fluorinated MT?45 derivatives have higher apparent potencies (2F?MT?45: 42 nM) than MT?45 (1.3 ?M) for inhibition of cAMP accumulation and ??arrestin2 recruitment (2F?MT?45: 196 nM; MT?45: 23.1 ?M).
EC50
Structure of PIVALOYL FENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of N-(2-APB) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ISOTODESNITAZENE
AGONIST -> TARGET
Emax=94.9 relative to Fentanyl
EC50
Structure of N-(DOM) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of NALMEFENE
INHIBITOR -> TARGET
Structure of U-48800
AGONIST -> TARGET
Has around 7.5-fold the potency of morphine in animal models.
Structure of 2,3-Benzodioxole fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of TIANEPTINE
AGONIST -> TARGET
Atypical. G-protein activation
EC50
Structure of NALOXEGOL
INHIBITOR -> TARGET
Structure of BENZYLFENTANYL
AGONIST -> TARGET
Structure of 3'-methyl Acetyl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of AT-076
INHIBITOR -> TARGET
ANTAGONIST
Structure of N-DESETHYLETONITAZENE
AGONIST -> TARGET
EC50
Structure of N-(2C-P) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of NALDEMEDINE-CARBOXYLIC ACID
INHIBITOR -> TARGET
Structure of 5-AMINOISOTONITAZENE
AGONIST -> TARGET
EC50
Structure of .BETA.-HYDROXYFENTANYL
AGONIST -> TARGET
EC50
Structure of NAPHTHYL-U-47700
AGONIST -> TARGET
Structure of ECLANAMINE
AGONIST -> TARGET
Assumed from being on CDC list
Structure of N-(3,4,5-TMA) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of TRIFLUOROFENTANYL
AGONIST -> TARGET
Structure of .ALPHA.-NALOXOL
INHIBITOR -> TARGET
Structure of 4-CHLOROFENTANYL
AGONIST -> TARGET
ED50(mg/kg) = 0.220, Potency ratio to morphine = 1.5, Potency ratio to fentanyl = 0.03
Structure of Benzodioxole fentanyl
AGONIST -> TARGET
Structure of ETHYLNITAZENE
AGONIST -> TARGET
POTENCY
Structure of DPDPE
INHIBITOR -> TARGET
IC50
Structure of 3-METHYLFENTANYL, CIS-
AGONIST -> TARGET
EC50
Structure of 4-PHENYLFENTANYL
AGONIST -> TARGET
Structure of N-(DOI) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of LY-2795050 C-11
RADIOLIGAND->OFF TARGET
Ki
Structure of N-(2C-B-FLY) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of BROMADOL
AGONIST -> TARGET
The antinociceptive ED50 in mouse hot plate of the two compounds were 11.5 ?g/kg and 13.4 ?g/kg respectively.
Ki
Structure of Phenoxyacetyl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of .ALPHA.-METHYLTHIOFENTANYL
AGONIST -> TARGET
Structure of FENTRANYL
AGONIST -> TARGET
Structure of Ortho-hydroxycarfentanil
AGONIST -> TARGET
Lance Ultra cAMP Assay
EC50
Structure of ?-keto-Carfentanil
AGONIST -> TARGET
Lance Ultra cAMP Assay
EC50
Structure of SECOFENTANYL
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ETONITAZENE 6-NITRO ISOMER
AGONIST -> TARGET
POTENCY
Structure of N-(3-ethylindole) Norfentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of Ohmefentanyl
AGONIST -> TARGET
IC50 of Fentanyl= 1.23 NM
IC50
Structure of Oxycodone
AGONIST -> TARGET
Structure of N-(2,5-DMA) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ?-hydroxy-Carfentanil
AGONIST -> TARGET
Lance Ultra cAMP Assay
EC50
Structure of FLUNITAZENE
AGONIST -> TARGET
In vitro data suggest that flunitazene is much less potent than fentanyl. Emax=118% of Fentanyl
EC50
Structure of BUCINNAZINE
AGONIST -> TARGET
Structure of meta-methyl Acetyl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ETONITAZENE
AGONIST -> TARGET
Emax=134% of Fentanyl
EC50
Structure of ETONITAZENE MORPHOLINE ANALOGUE
AGONIST -> TARGET
POTENCY
Structure of TRV-0109662
AGONIST -> TARGET
TRV0109662 is a weak (EC50= 5 mcM) partial agonist of the human mu-opioid receptor.
PARTIAL AGONIST
EC50
Structure of LY-2795050
INHIBITOR->OFF-TARGET
Ki
Structure of ORP-101
AGONIST -> TARGET
Structure of 1-DIETHYLAMINOETHYL-2-BENZYL-BENZIMIDAZOLE
WEAK AGONIST->TARGET
POTENCY
Structure of Cyclopropaneacetyl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of CIS-3-ISO-PROPYL FENTANYL
NON-INHIBITOR->OFF TARGET
ED50
Structure of ORTHOFLUOROFENTANYL
AGONIST -> TARGET
Structure of U-48520
AGONIST -> TARGET
Assumed from being on CDC list
Structure of CYX-6
AGONIST -> TARGET
Structure of CLONITAZENE
AGONIST -> TARGET
Emax=106 of Fentanyl
EC50
Structure of DAMGO
AGONIST -> TARGET
Ki
Structure of ?-Funaltrexamine
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
Structure of 2-METHYLFENTANYL
AGONIST -> TARGET
RAT OPIOD RECEPTOR; POTENCY RELATIVE TO MORPHINE 4.0
AGONIST
IC50
Structure of META-METHYLFENTANYL
AGONIST -> TARGET
Structure of AH-7921
AGONIST -> TARGET
Structure of ETONITAZENE N,N-DIMETHYL ANALOGUE
AGONIST -> TARGET
POTENCY
Structure of Samidorphan
INHIBITOR -> TARGET
Structure of ACETYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of N-DESETHYLISOTONITAZENE
AGONIST -> TARGET
Emax =140% of Fentanyl. In vitro data shows that N-desethyl isotonitazene is similar in potency to etonitazene, and approximately 20 times more potent than fentanyl.
EC50
Structure of ETODESNITAZENE
AGONIST -> TARGET
Structure of 3',5'-dimethoxy Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of PROPYLNITAZENE
AGONIST -> TARGET
POTENCY
Structure of THIOFENTANYL
AGONIST -> TARGET
Structure of METENKEFALIN
AGONIST -> TARGET
Structure of N-(2C-D) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
3-METHYLBUTYRFENTANYL
AGONIST -> TARGET
Structure of NORTILIDINE
AGONIST -> TARGET
Inhibition of forskolin-induced cAMP accumulation.
IC50
Structure of N-(Phentermine) fentanyl
AGONIST -> TARGET
Structure of 3',4'-Dimethoxy Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of Despropionyl meta-Methylfentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of P-BROMOFENTANYL
AGONIST -> TARGET
Rat tail withdrawal test. Morphine ED50 3.15. Fentanyl ED50 0.1 mg/mL
ED50
Structure of ortho-methyl Furanylfentanyl
AGONIST -> TARGET
Structure of CYT-1010
AGONIST -> TARGET
Structure of NALBUPHINE
INHIBITOR -> TARGET
Structure of iso-Butanoyl-4-fluorofentanyl
AGONIST -> TARGET
Assumed active
Structure of NOR-NALDEMEDINE
INHIBITOR -> TARGET
Structure of N-Pyrrolidino Metonitazene
AGONIST -> TARGET
An active opioid with potency approximately two times greater than that of fentanyl [unpublished data from L. De Vrieze and C. Stove].
Structure of TETRAHYDROFURANYL FENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of SR-17018
AGONIST -> TARGET
Structure of CYCLOPENTYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of N-DESMETHYL-BDPC
AGONIST -> TARGET
Structure of PYRROLE-FENTANYL
AGONIST -> TARGET
Structure of para-fluoro 4-ANBP
AGONIST -> TARGET
Assumed from being on CDC list
Structure of N-Pyrrolidino Protonitazene
AGONIST -> TARGET
An active opioid with potency approximately 25 times greater than that of fentanyl [unpublished data from L. De Vrieze and C. Stove].
Structure of PARA-METHYL ACRYLFENTANYL
AGONIST -> TARGET
Structure of TRAMADOL, (+)-
AGONIST -> TARGET
Structure of BW-942C
AGONIST -> TARGET
Structure of N-PHENYL-N-((1-(2-PHENYLETHYL)PIPERIDIN-4-YL)METHYL)PROPANAMIDE
AGONIST -> TARGET
Structure of Lumekefamide
AGONIST -> TARGET
Structure of OXYCODEGOL
AGONIST -> TARGET
Structure of 2',5'-Dimethoxy 4'-iodo fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of 4-METHYLPHENETHYLACETYLFENTANYL
AGONIST -> TARGET
Structure of 3-METHYLFURANYLFENTANYL
AGONIST -> TARGET
Structure of PROTODESNITAZENE
AGONIST -> TARGET
EC50
Structure of BISNORTILIDINE
AGONIST -> TARGET
Structure of N-(DOB) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of U-47700
AGONIST -> TARGET
Structure of RR-49
AGONIST -> TARGET
Structure of .ALPHA.-METHYL-METONITAZENE
AGONIST -> TARGET
POTENCY
Structure of p-Fluorofentanyl
AGONIST -> TARGET
EC50
BETA-ENDORPHIN HUMAN
AGONIST -> TARGET
Very high affinity for receptor
IC50
Structure of ELUXADOLINE
AGONIST -> TARGET
Structure of para-chloro Furanyl fentanyl
AGONIST -> TARGET
Structure of P-TOLYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of ACETOXYNITAZENE
AGONIST -> TARGET
POTENCY
Structure of BUTONITAZENE
AGONIST -> TARGET
Butonitazene is tens of times superior to morphine when administered intravenously, as was found in chemical studies in rodents. Emax=103% of Fentanyl. beta-Arrestin assay
EC50
Structure of para-Chloroacetyl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of 3-METHYLFENTANYL, (3R,4R)-
AGONIST -> TARGET
Mouse hot plate test. 1516 times more potent than morphine.
ED50
Structure of meta-Fluoro furanylfentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of AP-238
AGONIST -> TARGET
Structure of ETONITAZEPYNE
AGONIST -> TARGET
Structure of Ethyl 4-ANPP
WEAK AGONIST->TARGET
Presumed to be weak agonist.
Structure of SUFENTANIL
AGONIST -> TARGET
10 times more potent than Fentanyl.
Structure of ISOTONITAZENE
AGONIST -> TARGET
Emax 180 of hydromorphone
BIOASSAY (CELLULAR)
EC50
Structure of LOFENTANIL
AGONIST -> TARGET
IC50 of Fentanyl= 1.23 NM
IC50
Structure of MORPHINE-6-GLUCURONIDE
AGONIST -> TARGET
Ki
Structure of ETOETONITAZENE
AGONIST -> TARGET
POTENCY
Structure of NALDEMEDINE 3-O-.BETA.-D-GLUCURONIDE
INHIBITOR -> TARGET
Structure of para-Chloro furanyl fentanyl 3-furancarboxamide
AGONIST -> TARGET
Assumed from being on CDC list
Structure of N-(2C-T-4) Fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of 2-METHOXYFENTANYL
AGONIST -> TARGET
RAT OPIOD RECEPTOR; POTENCY RELATIVE TO MORPHINE 2.1
AGONIST
IC50
Structure of N-METHYLCARFENTANIL
AGONIST -> TARGET
Structure of Fentanyl Methyl Carbamate
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ?-Hydroxy-furanylfentanyl
AGONIST -> TARGET
EC50
Structure of ASALHYDROMORPHONE
AGONIST -> TARGET
Structure of 4-FLUORO FURANYLFENTANYL
AGONIST -> TARGET
Structure of T-BUTYLNITAZENE
AGONIST -> TARGET
POTENCY
Structure of METHADONE
AGONIST -> TARGET
Prolonged exposure methadone induces MOPr internalization comparable with that induced by DAMGO, whereas morphine produces much less MOPr heroin during relapse is due to receptor internalization. The blunting of the response to desensitization not receptor antagonism.
Structure of META-FLUOROISOBUTYRYL FENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of Carfentanil
AGONIST -> TARGET
IC50 of Fentanyl= 1.23 NM
IC50
Structure of meta-methoxy Furanyl fentanyl
AGONIST -> TARGET
Assumed from being on CDC list
Structure of ORTHO-FLUOROISOBUTYRYL FENTANYL
AGONIST -> TARGET
EC50
Structure of PARA-FLUORO ACRYLFENTANYL
AGONIST -> TARGET
EC50
Structure of PHARAOH FENTANYL
AGONIST -> TARGET
Structure of METONITAZENE
AGONIST -> TARGET
Emax=113% relative to Fentanyl
EC50
Structure of 3-METHYLFENTANYL, (3R,4S)-
AGONIST -> TARGET
Mouse hot plate test. 2600 times more potent than morphine.
ED50
Structure of TREFENTANIL
AGONIST -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_365] [1_377] DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_372] THREONINE PHOSPHATE 3L4WX7B1EI
AMINO ACID SUBSTITUTION [1_168] TYROSINE O-PHOSPHATE 2R86C98KDX
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
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