U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
116683
Substance Class Protein
Created
by admin
on Fri Jun 25 20:51:11 UTC 2021
Edited
by admin
on Fri Jun 25 20:51:11 UTC 2021
Protein Sub Type
Sequence Type COMPLETE
Record UNII
1PE72K8X46
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MU-TYPE OPIOID RECEPTOR
Common Name English
MU OPIOID RECEPTOR
Common Name English
M-OR-1
Common Name English
MOR1
Common Name English
MOP
Common Name English
HMOP
Common Name English
MOR-1
Common Name English
MU OPIATE RECEPTOR
Common Name English
Code System Code Type Description
UNIPROT
P35372
Created by admin on Fri Jun 25 20:51:11 UTC 2021 , Edited by admin on Fri Jun 25 20:51:11 UTC 2021
PRIMARY
FDA UNII
1PE72K8X46
Created by admin on Fri Jun 25 20:51:11 UTC 2021 , Edited by admin on Fri Jun 25 20:51:11 UTC 2021
PRIMARY
From To
1_142 1_219
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_9
N 1_12
N 1_33
N 1_40
N 1_48
Related Record Type Details
Structure of THIAFENTANIL
AGONIST -> TARGET
Structure of N-PHENYLPROPYLNORFENTANYL
AGONIST -> TARGET
Structure of OLICERIDINE
AGONIST -> TARGET
Structure of BEVENOPRAN
AGONIST -> TARGET
PHENARIDINE
AGONIST -> TARGET
Structure of ISOBUTYRYLFENTANYL
AGONIST -> TARGET
Structure of CYCLOPROPYL FENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of 7-HYDROXYMITRAGYNINE
AGONIST -> TARGET
Reported to have 13X the potency of morphine
Structure of PHENYLFENTANYL
AGONIST -> TARGET
Structure of AMDAKEFALIN
AGONIST -> TARGET
Structure of PYRIDIN-4-YLETHYL-NORFENTANYL
AGONIST -> TARGET
Structure of PIPERIDYLTHIAMBUTENE
AGONIST -> TARGET
An opioid analgesic drug from the thiambutene family, which has around the same potency as morphine.
Structure of ACRYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of TETRAMETHYLCYCLOPROPYLFENTANYL
AGONIST -> TARGET
Structure of THENYLFENTANYL
AGONIST -> TARGET
Structure of METHADONE
ANTAGONIST->TARGET
Structure of ISOFENTANYL
AGONIST -> TARGET
Structure of 3-PHENYLPROPANOYLFENTANYL
AGONIST -> TARGET
Structure of BUTYRFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of CYCLOBUTYLFENTANYL
AGONIST -> TARGET
EC50
Structure of ORTHO-FLUORO ACRYLFENTANYL
AGONIST -> TARGET
EC50
Structure of META-FLUOROFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of OCFENTANIL
AGONIST -> TARGET
Structure of FURANYLETHYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of MT-45
AGONIST -> TARGET
Structure of 2-CHLOROFENTANYL
AGONIST -> TARGET
RAT OPIOD RECEPTOR; POTENCY RELATIVE TO MORPHINE 2.5
AGONIST
IC50
Structure of PARAFLUOROISOBUTYRYLBENZYLFENTANYL
AGONIST -> TARGET
Structure of METHOXYACETYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of BETACETYLMETHADOL
AGONIST -> TARGET
Structure of BRORPHINE
AGONIST -> TARGET
Structure of 2,2'-DIFLUOROFENTANYL
AGONIST -> TARGET
Structure of 2-FURANYLFENTANYL
AGONIST -> TARGET
Blood furanylfentanyl concentrations are expected to be in a range of 1-45 ?g/L in victims of fatal overdosage.[
Structure of FENTANYL
AGONIST -> TARGET
HUMAN RECEPTOR
AGONIST
Ki
Structure of ORTHO-ISOPROPYLFURANYLFENTANYL
AGONIST -> TARGET
Structure of ORTHO-METHOXYFURANYLFENTANYL
AGONIST -> TARGET
Structure of ORTHO-FLUOROBUTYRYL FENTANYL
AGONIST -> TARGET
EC50
Structure of REMIFENTANIL
AGONIST -> TARGET
Structure of PARA-METHOXYBUTYRYL FENTANYL
AGONIST -> TARGET
Structure of NALDEMEDINE
INHIBITOR -> TARGET
Structure of .ALPHA.-METHYL-.BETA.-HYDROXYFENTANYL
AGONIST -> TARGET
Structure of MIRFENTANIL
AGONIST -> TARGET
3-METHYLFENTANYL
AGONIST -> TARGET
NFEPP
AGONIST -> TARGET
Structure of BRIFENTANIL
AGONIST -> TARGET
Structure of .BETA.-HYDROXYTHIOFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of 4-FLUOROISOBUTYRFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of O-METHYL ACETYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of ACETYL-.ALPHA.-METHYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of TRAMADOL
AGONIST -> TARGET
(+)-isomer
COMPETITIVE INHIBITOR
Ki
Structure of ALVIMOPAN
AGONIST -> TARGET
Structure of 4-FLUOROBUTYRFENTANYL
AGONIST -> TARGET
Structure of R-30490
AGONIST -> TARGET
Structure of CEBRANOPADOL
AGONIST -> TARGET
Structure of METHYLNALTREXONE
INHIBITOR -> TARGET
Cannot cross blood-brain barrier due to positive charge
Structure of 6-ACETYLMORPHINE
AGONIST -> TARGET
Structure of PARA-CHLOROISOBUTYRYL FENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of 3-FURANYLFENTANYL
AGONIST -> TARGET
Structure of ALVIMOPAN ANHYDROUS
INHIBITOR -> TARGET
Ki
Structure of TAPENTADOL
AGONIST -> TARGET
Structure of .ALPHA.-METHYL-BUTYRFENTANYL
AGONIST -> TARGET
Structure of ALFENTANIL
AGONIST -> TARGET
Structure of METHYL-AP-237
AGONIST -> TARGET
Structure of 3-METHYLTHIOFENTANYL
AGONIST -> TARGET
Structure of .BETA.-METHYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of HERKINORIN
AGONIST -> TARGET
Herkinorin is a ?-opioid agonist with more than 100x higher ?-opioid affinity and 50x lower ?-opioid affinity compared to Salvinorin A.
Structure of NALOXONE
INHIBITOR -> TARGET
Mu Receptor [3H]DAMGO BINDING INHIBITION
BINDING
Ki
Structure of NALTREXONE
INHIBITOR -> TARGET
Structure of 3-METHYLFENTANYL, TRANS-
AGONIST -> TARGET
EC50
Structure of 4-METHYL CYCLOPROPYL FENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of DESMETRAMADOL
AGONIST -> TARGET
Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to ?-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in ?-opioid binding.
Structure of .ALPHA.-METHYLFENTANYL
AGONIST -> TARGET
Structure of GPA-3154
PARTIAL AGONIST->TARGET
Structure of VALERYLFENTANYL
AGONIST -> TARGET
Structure of PIVALOYL FENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of NALMEFENE
INHIBITOR -> TARGET
Structure of NALOXEGOL
INHIBITOR -> TARGET
Structure of BENZYLFENTANYL
AGONIST -> TARGET
Structure of BUPRENORPHINE
PARTIAL AGONIST->TARGET
PARTIAL AGONIST
BINDING
Ki
Structure of AT-076
INHIBITOR -> TARGET
ANTAGONIST
Structure of .BETA.-HYDROXYFENTANYL
AGONIST -> TARGET
Structure of TRIFLUOROFENTANYL
AGONIST -> TARGET
Structure of 4-CHLOROFENTANYL
AGONIST -> TARGET
ED50(mg/kg) = 0.220, Potency ratio to morphine = 1.5, Potency ratio to fentanyl = 0.03
Structure of BENZODIOXOLEFENTANYL
AGONIST -> TARGET
Structure of 3-METHYLFENTANYL, CIS-
AGONIST -> TARGET
EC50
Structure of 4-PHENYLFENTANYL
AGONIST -> TARGET
Structure of .ALPHA.-METHYLTHIOFENTANYL
AGONIST -> TARGET
Structure of FENTRANYL
AGONIST -> TARGET
Structure of SECOFENTANYL
AGONIST -> TARGET
Structure of OHMEFENTANYL
AGONIST -> TARGET
Structure of OXYCODONE
AGONIST -> TARGET
Structure of BUCINNAZINE
AGONIST -> TARGET
Structure of TRV-0109662
AGONIST -> TARGET
TRV0109662 is a weak (EC50= 5 mcM) partial agonist of the human mu-opioid receptor.
PARTIAL AGONIST
EC50
Structure of ORP-101
AGONIST -> TARGET
Structure of ORTHOFLUOROFENTANYL
AGONIST -> TARGET
Structure of DESPROPIONYL PARA-FLUOROFENTANYL
AGONIST -> TARGET
Structure of CLONITAZENE
AGONIST -> TARGET
Structure of 2-METHYLFENTANYL
AGONIST -> TARGET
RAT OPIOD RECEPTOR; POTENCY RELATIVE TO MORPHINE 4.0
AGONIST
IC50
Structure of META-METHYLFENTANYL
AGONIST -> TARGET
Structure of AH-7921
AGONIST -> TARGET
Structure of SAMIDORPHAN
INHIBITOR -> TARGET
Structure of ACETYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of THIOFENTANYL
AGONIST -> TARGET
3-METHYLBUTYRFENTANYL
AGONIST -> TARGET
Structure of NALBUPHINE
INHIBITOR -> TARGET
Structure of NOR-NALDEMEDINE
INHIBITOR -> TARGET
Structure of TETRAHYDROFURANYL FENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of CYCLOPENTYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of PYRROLE-FENTANYL
AGONIST -> TARGET
Structure of TRAMADOL, (+)-
AGONIST -> TARGET
Structure of BW-942C
AGONIST -> TARGET
Structure of 4-METHYLPHENETHYLACETYLFENTANYL
AGONIST -> TARGET
Structure of 3-METHYLFURANYLFENTANYL
AGONIST -> TARGET
Structure of U-47700
AGONIST -> TARGET
Structure of PARAFLUOROFENTANYL
AGONIST -> TARGET
EC50
Structure of PARA-CHLOROFURANYLFENTANYL
AGONIST -> TARGET
Structure of P-TOLYLFENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of SUFENTANIL
AGONIST -> TARGET
Structure of ISOTONITAZENE
AGONIST -> TARGET
Emax 180 of hydromorphone
BIOASSAY (CELLULAR)
EC50
Structure of LOFENTANIL
AGONIST -> TARGET
Structure of NALDEMEDINE 3-O-.BETA.-D-GLUCURONIDE
INHIBITOR -> TARGET
Structure of 2-METHOXYFENTANYL
AGONIST -> TARGET
RAT OPIOD RECEPTOR; POTENCY RELATIVE TO MORPHINE 2.1
AGONIST
IC50
Structure of N-METHYLCARFENTANIL
AGONIST -> TARGET
Structure of ASALHYDROMORPHONE
AGONIST -> TARGET
Structure of 4-FLUOROFURANYL FENTANYL
AGONIST -> TARGET
Structure of METHADONE
INHIBITOR -> TARGET
Structure of META-FLUOROISOBUTYRYL FENTANYL
AGONIST -> TARGET
BINDING
Ki
Structure of CARFENTANIL
AGONIST -> TARGET
Structure of ORTHO-FLUOROISOBUTYRYL FENTANYL
AGONIST -> TARGET
EC50
Structure of PARA-FLUORO ACRYLFENTANYL
AGONIST -> TARGET
EC50
Structure of PHARAOH FENTANYL
AGONIST -> TARGET
Structure of TREFENTANIL
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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