U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Fri Jun 25 20:51:11 UTC 2021
Edited
by admin
on Fri Jun 25 20:51:11 UTC 2021
Protein Sub Type
Sequence Type COMPLETE
Record UNII
1PE72K8X46
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MU-TYPE OPIOID RECEPTOR
Common Name English
MU OPIOID RECEPTOR
Common Name English
M-OR-1
Common Name English
MOR1
Common Name English
MOP
Common Name English
HMOP
Common Name English
MOR-1
Common Name English
MU OPIATE RECEPTOR
Common Name English
Code System Code Type Description
UNIPROT
P35372
Created by admin on Fri Jun 25 20:51:11 UTC 2021 , Edited by admin on Fri Jun 25 20:51:11 UTC 2021
PRIMARY
FDA UNII
1PE72K8X46
Created by admin on Fri Jun 25 20:51:11 UTC 2021 , Edited by admin on Fri Jun 25 20:51:11 UTC 2021
PRIMARY
From To
1_142 1_219
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_9
N 1_12
N 1_33
N 1_40
N 1_48
Related Record Type Details
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
Reported to have 13X the potency of morphine
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
An opioid analgesic drug from the thiambutene family, which has around the same potency as morphine.
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
AGONIST -> TARGET
ANTAGONIST->TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
AGONIST -> TARGET
RAT OPIOD RECEPTOR; POTENCY RELATIVE TO MORPHINE 2.5
AGONIST
IC50
AGONIST -> TARGET
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Blood furanylfentanyl concentrations are expected to be in a range of 1-45 ?g/L in victims of fatal overdosage.[
AGONIST -> TARGET
HUMAN RECEPTOR
AGONIST
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
(+)-isomer
COMPETITIVE INHIBITOR
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
Cannot cross blood-brain barrier due to positive charge
AGONIST -> TARGET
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
Herkinorin is a ?-opioid agonist with more than 100x higher ?-opioid affinity and 50x lower ?-opioid affinity compared to Salvinorin A.
INHIBITOR -> TARGET
Mu Receptor [3H]DAMGO BINDING INHIBITION
BINDING
Ki
INHIBITOR -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to ?-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in ?-opioid binding.
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
AGONIST -> TARGET
AGONIST -> TARGET
BINDING
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
PARTIAL AGONIST
BINDING
Ki
INHIBITOR -> TARGET
ANTAGONIST
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
ED50(mg/kg) = 0.220, Potency ratio to morphine = 1.5, Potency ratio to fentanyl = 0.03
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
TRV0109662 is a weak (EC50= 5 mcM) partial agonist of the human mu-opioid receptor.
PARTIAL AGONIST
EC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
RAT OPIOD RECEPTOR; POTENCY RELATIVE TO MORPHINE 4.0
AGONIST
IC50
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
AGONIST -> TARGET
Emax 180 of hydromorphone
BIOASSAY (CELLULAR)
EC50
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
RAT OPIOD RECEPTOR; POTENCY RELATIVE TO MORPHINE 2.1
AGONIST
IC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
BINDING
Ki
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL