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Details

Stereochemistry ACHIRAL
Molecular Formula C35H32N6O4
Molecular Weight 600.6664
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of DERSALAZINE

SMILES

CC1=NC2=CN=CC=C2N1CC3CCN(CC3)C(=O)\C=C(\C4=CC=CC=C4)C5=CC=C(C=C5)\N=N\C6=CC=C(O)C(=C6)C(O)=O

InChI

InChIKey=AYEAMZDTWLXZIJ-RKOUKRECSA-N
InChI=1S/C35H32N6O4/c1-23-37-31-21-36-16-13-32(31)41(23)22-24-14-17-40(18-15-24)34(43)20-29(25-5-3-2-4-6-25)26-7-9-27(10-8-26)38-39-28-11-12-33(42)30(19-28)35(44)45/h2-13,16,19-21,24,42H,14-15,17-18,22H2,1H3,(H,44,45)/b29-20-,39-38+

HIDE SMILES / InChI

Molecular Formula C35H32N6O4
Molecular Weight 600.6664
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 2
Optical Activity NONE

Dersalazine is a locally-acting compound. It is a potent platelet activating factor (PAF)-antagonist. Dersalazine inhibited IL-1beta or TNF-alpha production in THP-1 or U937 cells, respectively. Dersalazine sodium reduced colonic proinflammatory cytokines IL-1b, IL-6, and IL-17 in dextran sodium sulphate (DSS)–induced colitis. After oral administration, dersalazine sodium is mostly unabsorbed until it reaches the large bowel where the azo bond is reduced by bacteria releasing the active compound. Dersalazine had been in phase I clinical trial for the treatment of ulcerative colitis. No serious adverse reactions were detected in clinical trial. However, no recent development has been reported.

Approval Year

Sample Use Guides

1200 mg/12 h for 4 weeks
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 16:52:05 GMT 2023
Edited
by admin
on Sat Dec 16 16:52:05 GMT 2023
Record UNII
WS1IH75AJT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DERSALAZINE
INN   WHO-DD  
INN  
Official Name English
dersalazine [INN]
Common Name English
Dersalazine [WHO-DD]
Common Name English
UR-12746
Code English
2-HYDROXY-5-((4-((1Z)-3-(4-((2-METHYL-1H-IMIDAZO(4,5-C)PYRIDIN-1-YL)METHYL)PIPERIDIN-1-YL)-3-OXO-1-PHENYLPROP-1-ENYL)PHENYL)DIAZENYL)BENZOIC ACID
Systematic Name English
BENZOIC ACID, 2-HYDROXY-5-((4-((1Z)-3-(4-((2-METHYL-1H-IMIDAZO(4,5-C)PYRIDIN-1-YL)METHYL)-1-PIPERIDINYL)-3-OXO-1-PHENYL-1-PROPENYL)PHENYL)AZO)-
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C308
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
Code System Code Type Description
INN
8194
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
PRIMARY
FDA UNII
WS1IH75AJT
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
PRIMARY
PUBCHEM
9808813
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
PRIMARY
CAS
188913-58-8
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
PRIMARY
DRUG BANK
DB06251
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
PRIMARY
SMS_ID
300000034116
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106406
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
PRIMARY
NCI_THESAURUS
C77949
Created by admin on Sat Dec 16 16:52:05 GMT 2023 , Edited by admin on Sat Dec 16 16:52:05 GMT 2023
PRIMARY
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ACTIVE MOIETY
ACTIVE MOIETY