Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C35H31N6O4.Na |
| Molecular Weight | 622.6482 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CC1=NC2=CN=CC=C2N1CC3CCN(CC3)C(=O)\C=C(\C4=CC=CC=C4)C5=CC=C(C=C5)\N=N\C6=CC=C(O)C(=C6)C([O-])=O
InChI
InChIKey=YLEYSRAGECECMB-UUHDFEAYSA-M
InChI=1S/C35H32N6O4.Na/c1-23-37-31-21-36-16-13-32(31)41(23)22-24-14-17-40(18-15-24)34(43)20-29(25-5-3-2-4-6-25)26-7-9-27(10-8-26)38-39-28-11-12-33(42)30(19-28)35(44)45;/h2-13,16,19-21,24,42H,14-15,17-18,22H2,1H3,(H,44,45);/q;+1/p-1/b29-20-,39-38+;
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C35H31N6O4 |
| Molecular Weight | 599.6584 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Optical Activity | NONE |
Dersalazine is a locally-acting compound. It is a potent platelet activating factor (PAF)-antagonist. Dersalazine inhibited IL-1beta or TNF-alpha production in THP-1 or U937 cells, respectively. Dersalazine sodium reduced colonic proinflammatory cytokines IL-1b, IL-6, and IL-17 in dextran sodium sulphate (DSS)–induced colitis. After oral administration, dersalazine sodium is mostly unabsorbed until it reaches the large bowel where the azo bond is reduced by bacteria releasing the active compound. Dersalazine had been in phase I clinical trial for the treatment of ulcerative colitis. No serious adverse reactions were detected in clinical trial. However, no recent development has been reported.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:39:40 GMT 2023
by
admin
on
Sat Dec 16 01:39:40 GMT 2023
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| Record UNII |
BAB844203H
|
| Record Status |
Validated (UNII)
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| Record Version |
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57331752
Created by
admin on Sat Dec 16 01:39:40 GMT 2023 , Edited by admin on Sat Dec 16 01:39:40 GMT 2023
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BAB844203H
Created by
admin on Sat Dec 16 01:39:40 GMT 2023 , Edited by admin on Sat Dec 16 01:39:40 GMT 2023
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DBSALT002003
Created by
admin on Sat Dec 16 01:39:40 GMT 2023 , Edited by admin on Sat Dec 16 01:39:40 GMT 2023
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367249-56-7
Created by
admin on Sat Dec 16 01:39:40 GMT 2023 , Edited by admin on Sat Dec 16 01:39:40 GMT 2023
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
