CLOTHIXAMIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H28ClN3OS
Molecular Weight	442.017
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of CLOTHIXAMIDE

Structure Search

SMILES

CNC(=O)CCN1CCN(CCC=C2C3=CC=CC=C3SC4=CC=C(Cl)C=C24)CC1

InChI

InChIKey=WXFFTUKVTRHPLQ-UHFFFAOYSA-N

InChI=1S/C24H28ClN3OS/c1-26-24(29)10-12-28-15-13-27(14-16-28)11-4-6-19-20-5-2-3-7-22(20)30-23-9-8-18(25)17-21(19)23/h2-3,5-9,17H,4,10-16H2,1H3,(H,26,29)

HIDE SMILES / InChI

Description
Sources: https://www.sciencedirect.com/science/article/abs/pii/0024320579900961 | https://patents.google.com/patent/US3196150A/en

Clothixamide is a dopamine antagonist. The compound was invented by Pfizer in the 1960s and is claimed to be useful for the chemotherapy of mental diseases and especially for the control of excited states. Also, clothixamide is claimed to have potent antiemetic properties.

Approval Year

Name

Type

Language

CLOTIXAMIDE

Preferred Name

English

CLOTHIXAMIDE

Common Name

English

1-PIPERAZINEPROPANAMIDE, 4-(3-(2-CHLORO-9H-THIOXANTHEN-9-YLIDENE)PROPYL)-N-METHYL-

Systematic Name

English

4-(3-(2-CHLOROTHIOXANTHEN-9-YLIDENE)PROPYL)-N-METHYL-1-PIPERAZINEPROPIONAMIDE

Systematic Name

English

clotixamide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66883

Created by admin on Wed Apr 02 08:29:04 GMT 2025 , Edited by admin on Wed Apr 02 08:29:04 GMT 2025

NCI_THESAURUS

C29710

Created by admin on Wed Apr 02 08:29:04 GMT 2025 , Edited by admin on Wed Apr 02 08:29:04 GMT 2025

Code System Code Type Description

EPA CompTox

DTXSID40194593

Created by admin on Wed Apr 02 08:29:04 GMT 2025 , Edited by admin on Wed Apr 02 08:29:04 GMT 2025

PRIMARY

CAS

4177-58-6

Created by admin on Wed Apr 02 08:29:04 GMT 2025 , Edited by admin on Wed Apr 02 08:29:04 GMT 2025

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SMS_ID

100000084054

Created by admin on Wed Apr 02 08:29:04 GMT 2025 , Edited by admin on Wed Apr 02 08:29:04 GMT 2025

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ChEMBL

CHEMBL2110894

Created by admin on Wed Apr 02 08:29:04 GMT 2025 , Edited by admin on Wed Apr 02 08:29:04 GMT 2025

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NCI_THESAURUS

C81092

Created by admin on Wed Apr 02 08:29:04 GMT 2025 , Edited by admin on Wed Apr 02 08:29:04 GMT 2025

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INN

1853

Created by admin on Wed Apr 02 08:29:04 GMT 2025 , Edited by admin on Wed Apr 02 08:29:04 GMT 2025

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EVMPD

SUB06776MIG

Created by admin on Wed Apr 02 08:29:04 GMT 2025 , Edited by admin on Wed Apr 02 08:29:04 GMT 2025

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FDA UNII

24623E6DZD

Created by admin on Wed Apr 02 08:29:04 GMT 2025 , Edited by admin on Wed Apr 02 08:29:04 GMT 2025

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PUBCHEM

20495

Created by admin on Wed Apr 02 08:29:04 GMT 2025 , Edited by admin on Wed Apr 02 08:29:04 GMT 2025

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ACTIVE MOIETY


					24623E6DZD

SALT/SOLVATE (PARENT)


					DNS84NJF1Q

CLOTHIXAMIDE MALEATE