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Status:
First approved in 1953
Class:
MIXTURE
Targets:
Conditions:
Carbomycin is a complex mixture containing carbomycin A with a small portion of carbomycin B. Carbomycin is produced by Streptomyces halstedii and acts as an antibiotic. The drug was approved by FDA under the name Magna-terramycin (in combination with oxytetracycline) for the treatment of bacterial chronic respiratory diseases in chickens. Carbomycin exerts its antibacterial action by binding within the large ribosomal subunit and thus inhibiting the protein synthesis in bacterias.
Status:
US Previously Marketed
Source:
ERGOLOID MESYLATES by SUN PHARM INDUSTRIES
(1981)
Source URL:
First approved in 1953
Class:
MIXTURE
Targets:
Ergoloid mesylates (USAN), co-dergocrine mesilate (BAN) or dihydroergotoxine mesylate, trade name Hydergine, is a mixture of the methanesulfonate salts of three dihydrogenated ergot alkaloids (dihydroergocristine, dihydroergocornine, and alpha- and beta-dihydroergocryptine). It was developed by Albert Hofmann (the inventor of LSD) for Sandoz (now part of Novartis). Ergoloid mesylates act centrally, decreasing vascular tone and slowing the heart rate, and acts peripherally to block alpha-receptors. One other possible mechanism is the effect of ergoloid mesylates on neuronal cell metabolism, resulting in improved oxygen uptake and cerebral metabolism, thereby normalizing depressed neurotransmitter levels. Ergoloid Mesylate may increase cerebral metabolism and blood flow. The role of this medication in the therapy of dementia is controversial. A recent controlled study in patients with Alzheimer's disease found that there was no advantage to the use of ergoloid mesylates compared to placebo, suggesting that ergoloid mesylates may lower scores on some cognitive and behavioral rating scales. Further study is needed to determine the risk-benefit profile of ergoloid mesylates in the treatment of dementia.
Status:
First approved in 1945
Class:
MIXTURE
Conditions:
Chlorophyll is a green pigment present in plants, as well as in eukaryotic single-celled algae and in several photosynthetic prokaryotes (the cyanobacteria and prochlorophytes), it plays crucial role in photosynthesis. The initial step in photosynthesis is the absorption of light by chlorophylls attached to proteins in the thylakoid membranes. Like cytochromes, chlorophylls consist of a porphyrin ring attached to a long hydrocarbon side chain. The energy of the absorbed light is used to remove electrons from an unwilling donor (water, in green plants), forming oxygen, and then to transfer the electrons to a primary electron acceptor, a quinone designated Q, which is similar to CoQ. Chlorophyll derivatives Radachlorin/Bremachlorin and Radachlorophyll/Bremachlorophyll are actually a second generation photosensitizer for photodynamic therapy of malignant and benign pathologies. Radachlorophyll/Bremachlorophyll may change blood lipids and pressure, including: (1) reduced total cholesterol; (2) increased HDL cholesterol; (3) reduced triglycerides; and (4) reduced systolic and diastolic blood pressure as well as immunomodulating properties. As a dietary supplement chlorophyll supports multiple body systems: provides antioxidant activity, supports vascular health, supports the body's normal immune system function, provides cardiovascular support, maintains skin and hair health. Chlorophylls (E140) is used as a food additive.
Status:
First approved in 1942
Class:
MIXTURE
Tyrothricin is a mixture of non-ribosomal peptides produced by Brevibacillus brevis, now known as Aneurinibacillus migulanus, a gram positive aerobic bacteria. The compound mixture shows activity against bacteria, fungi and some viruses. A very interesting feature of AMPs is the fact, that even in vitro it is almost impossible to induce resistances. It is a locally effective antibiotic effective against gram-positive bacteria. It is sometimes combined with benzocaine 5 mg (Tyrozets) to provide relief from sore throats. Recommended for short-term relief of symptoms of oral and throat inflammation. Prevention of infections before/during mouth and throat operations (tooth extractions, gum surgical treatment). Tyrothricin inhibits protein biosynthesis of gram-positive organisms, but is completely ineffective against gram-negative.
Status:
US Previously Marketed
Source:
DEPINAR by ARMOUR PHARM
(1960)
Source URL:
First marketed in 1921
Class:
MIXTURE
Targets:
Tannic acid (TA) is a naturally occurring plant-derived polyphenol found in several herbaceous and woody plants, wines and a broad selection of teas. TA has strong antioxidant/free radical scavenging, anti-inflammatory, anti-viral/bacterial, and anti-carcinogenic properties. The neuroprotective effects of TA against Alzheimer’s disease (AD) have been shown in several in vitro and in vivo models of AD. Evidence suggests that TA is a natural inhibitor of β-secretase (BACE1) activity and protein expression. BACE1 is the primary enzyme responsible for the production and deposition of Aβ peptide. TA can also inhibit the in vitro aggregation of tau peptide, a core component of intracellular neurofibrillary tangles (NFTs). In addition, combination of tannic acid with eucalyptus Oil and Allantoin (from Comfrey) is known as homeopathic product which is used to temporarily relieve the aches and pains of muscles and joints associated with: arthritis, simple backache, strains, bruises, sprains.
Status:
US Previously Marketed
Source:
Mixed Tocopherols N.F.
(1921)
Source URL:
First marketed in 1921
Source:
Mixed Tocopherols N.F.
Source URL:
Class:
MIXTURE
Tocopherol (alpha tocopheryl nicotinate) is an ester of tocopherol and nicotinic acid. Vitamin E (Tocopherol) is sold commercially as the esterified form (alpha tocopheryl acetate, alpha tocopheryl succinate and alpha tocopheryl nicotinate). Alpha tocopheryl nicotinate has antioxidant and vasodilatory properties. It can be used as a mild warming agent, without producing the redness typical for nicotinic acid. Tocopherol (alpha tocopheryl nicotinate) has been available in Japan since 1967. Tocopherol under the brand name Juvela N is approved in Japan for the treatment of symptoms accompanying hypertension, hyperlipidemia, peripheral circulatory disturbance resulting from arteriosclerosis obliterans. Tocopherol has being shown to inhibit platelet aggregation.
Status:
Possibly Marketed Outside US
Source:
NCT03237182: Phase 4 Interventional Terminated Tuberculosis, Multidrug-Resistant
(2017)
Source URL:
First approved in 2022
Source:
Kanamycin Sulfates by KDG Impresa LLC, Aqion
Source URL:
Class:
MIXTURE
Targets:
Kanamycin (a mixture of kanamycin A, B and C) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. It is effective against Gram-negative bacteria and certain Gram-positive bacteria. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Serious side effects include tinnitus or loss of hearing, toxicity to kidneys, and allergic reactions to the drug. Mixing of an aminoglycoside with beta-lactam-type antibiotics (penicillins or cephalosporins) may result in a significant mutual inactivation. Even when an aminoglycoside and a penicillin-type drug are administered separately by different routes, a reduction in aminoglycoside serum half-life or serum levels has been reported in patients with impaired renal function and in some patients with normal renal function.
Status:
Possibly Marketed Outside US
First approved in 2015
Source:
NADA141438
Source URL:
Class:
MIXTURE
Targets:
Conditions:
Avilamycin is an orthosomycin antibiotic complex produced by the fermentation of Streptomyces viridochromogenes. Avilamycin is intended for use as a veterinary medicine in chickens, turkeys, pigs and rabbits to control bacterial enteric infections. It exhibits good antimicrobial activity against important veterinary Gram-positive pathogens (e.g., Clostridium perfringens) and has no related molecules in its class in human use. Therefore, avilamycin has been developed for treating necrotic enteritis in poultry, and enteric disease in pig and rabbits. Avilamycin inhibits bacterial protein synthesis through a novel mechanism of action by binding to the 50S ribosomal subunit and preventing the association of IF2, which inhibits the formation of the mature 70S initiation complex, and the correct positioning of tRNA in the aminoacyl site. No adverse drug-related changes were observed.
Status:
Possibly Marketed Outside US
First approved in 2009
Source:
Bambermycin Concentrate by Biovet Joint Stock Company
Source URL:
Class:
MIXTURE
Targets:
Conditions:
Bambermycins (flavomycin) is a complex of antibiotics obtained from Streptomyces bambergiensis and Streptomyces ghanaensis used as a food additive for poultry and swine. Inhibitor of the in vitro transglycosylase activities of PBPs. Bambermycins complex consists mainly of moenomycins A and C. Moenomycin A is the prototype for compounds that bind to bacterial peptidoglycan glycosyltransferases (PGTs) and inhibit cell wall biosynthesis
Status:
Possibly Marketed Outside US
First approved in 2008
Source:
BP Cleansing Wash by Acella Pharmaceuticals, LLC
Source URL:
Class:
MIXTURE
Conditions:
Disodium oleic monoethanolamine sulfosuccinate is excipient used in pharmaceutical and cosmetic as preservative and as non-toxic and non-irritating capsulated laundry detergent.