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Description
Curator's Comment: Description was created based on several sources, including http://www.fkog.uu.se/course/a/biolakt/biolakt-archive/litteratur2011ht/tyrotricin_Marie.pdf and http://www.eurosurveillance.org/images/dynamic/EE/V20N34/art21215.pdf

Tyrothricin is a mixture of non-ribosomal peptides produced by Brevibacillus brevis, now known as Aneurinibacillus migulanus, a gram positive aerobic bacteria. The compound mixture shows activity against bacteria, fungi and some viruses. A very interesting feature of AMPs is the fact, that even in vitro it is almost impossible to induce resistances. It is a locally effective antibiotic effective against gram-positive bacteria. It is sometimes combined with benzocaine 5 mg (Tyrozets) to provide relief from sore throats. Recommended for short-term relief of symptoms of oral and throat inflammation. Prevention of infections before/during mouth and throat operations (tooth extractions, gum surgical treatment). Tyrothricin inhibits protein biosynthesis of gram-positive organisms, but is completely ineffective against gram-negative.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Staphylococcus aureus growth
Target ID: Plasmodium falciparum growth
0.05 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Tyrozets

Approved Use

As an antibiotic and local analgesic-anaesthetic. For minor mouth and throat irritations; secondary irritation following tonsillectomy and other mouth and throat surgery.

Launch Date

2008
Primary
Unknown

Approved Use

Unknown
Curative
Tyrosur Powder

Approved Use

Indications: Surface wounds with insignificant release of exudate and with superinfection (erosive and ulcerous skin and mucous membrane lesions) caused by pathogenic microorganisms sensitive to Tyrothricin (infected eczema, purulent skin inflammations, burns).
PubMed

PubMed

TitleDatePubMed
Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis.
2007 Jun
Suppressive effects of peptide antibiotics against proliferation and cytokine production in mitogen-activated human peripheral-blood mononuclear cells.
2011
Trends in the susceptibility of methicillin-resistant Staphylococcus aureus to nine antimicrobial agents, including ceftobiprole, nemonoxacin, and tyrothricin: results from the Tigecycline In Vitro Surveillance in Taiwan (TIST) study, 2006-2010.
2014 Feb
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Can also be used topically for wounds treatment http://www.ndrugs.com/?s=tyrosur%20powder
Adults : 1 lozenge to be dissolved slowly in the mouth every three hours. Do not exceed 8 lozenges in 24 hours. Children aged 3 years and older : dosage should be reduced in children. Maximum 6 lozenges in 24 hours. Tyrozets are not recommended for children under the age of three years.
Route of Administration: Oral
In Vitro Use Guide
MIC90 of tyrothricin against methicillin-resistant Staphylococcus aureus isolates was 4 ug/ml
Name Type Language
TYROTHRICIN
INN   MI   USP   WHO-DD  
INN  
Official Name English
TYROTHRICIN [USP IMPURITY]
Common Name English
COLTIROT
Brand Name English
NSC-757363
Code English
tyrothricin [INN]
Common Name English
DUBOS CRUDE CRYSTALS
Common Name English
TYRI 10
Brand Name English
TYROZETS
Brand Name English
HYDROTRICINE
Brand Name English
TYROTHRICIN [MI]
Common Name English
Tyrothricin [WHO-DD]
Common Name English
TYROTHRICIN [USP MONOGRAPH]
Common Name English
TYRODERM
Brand Name English
DERMOTRICINE
Brand Name English
SOLUTRICINE
Brand Name English
BACTRATYCIN
Brand Name English
MARTRICIN
Brand Name English
TYROSUR
Brand Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 6311
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WHO-ATC S01AA05
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WHO-VATC QD06AX08
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WHO-ATC R02AB02
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WHO-VATC QR02AB02
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WHO-VATC QS01AA05
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WHO-ATC D06AX08
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NCI_THESAURUS C258
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Code System Code Type Description
NCI_THESAURUS
C152789
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PRIMARY
EVMPD
SUB05029MIG
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MERCK INDEX
m11293
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PRIMARY Merck Index
CAS
1404-88-2
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DRUG BANK
DB13503
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RXCUI
10968
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DRUG CENTRAL
4739
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NSC
757363
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WIKIPEDIA
TYROTHRICIN
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INN
1344
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FDA UNII
877376V2XW
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MESH
D014449
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EPA CompTox
DTXSID4045846
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ChEMBL
CHEMBL577736
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Definition References