BAMBERMYCINS

First approved in 2009

Description
Sources: https://www.drugs.com/vet/flavomycin-4.html | https://www.ncbi.nlm.nih.gov/pubmed/23448584

Bambermycins (flavomycin) is a complex of antibiotics obtained from Streptomyces bambergiensis and Streptomyces ghanaensis used as a food additive for poultry and swine. Inhibitor of the in vitro transglycosylase activities of PBPs. Bambermycins complex consists mainly of moenomycins A and C. Moenomycin A is the prototype for compounds that bind to bacterial peptidoglycan glycosyltransferases (PGTs) and inhibit cell wall biosynthesis

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Penicillin-binding protein 31 Target ID: CHEMBL2362973 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23448584 \| https://www.ncbi.nlm.nih.gov/pubmed/12325012 \| https://www.ncbi.nlm.nih.gov/pubmed/10441150	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Low weight in cattle 1 Sources: https://www.drugs.com/pro/flavomycin.html	Primary		Approved 8583	GAINPRO Approved Use For increased rate of weight gain and improved feed efficiency in cattle fed in confinement for slaughter (feedlot cattle). For increased rate of weight gain in pasture cattle (slaughter, stocker and feeder cattle, and dairy and beef replacement heifers). Launch Date 1998

PubMed

Title	Date	PubMed
Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors.	2013-03-13	23448584
Complete characterization of the seventeen step moenomycin biosynthetic pathway.	2009-09-22	19640006
Risk assessment of ciprofloxacin, flavomycin, olaquindox and colistin sulfate based on microbiological impact on human gut biota.	2009-04	19545513
Effect of flavophospholipol on conjugation frequency between Escherichia coli donor and recipient pairs in vitro and in the chicken gastrointestinal tract.	2006-08	16847028

Patents

Sample Use Guides

In Vivo Use Guide

Chickens: 1-2 Grams Swine: 2 Grams It is recommended that Flavomycin 4 (Bambermycins) be diluted with a suitable grain carrier before addition to the final feed. A dilution of 1 part of Flavomycin 4 and 9 parts grain carrier is the suggested working premix.

Route of Administration: Oral

In Vitro Use Guide

Of 10 predominant bacterial genera from the fresh human fecal samples, Fusobacterium spp. and Lactobacillus spp. were the most sensitively affected by flavomycin (Bambermycins) showing MIC50 value of 0.25 ug/ml at 1 x10(5) CFU/ml. ATCC-type Fusobacterium prausnitzii was also the most sensitive bacterium with same MIC value 0.25 ug/ml at 1x 10(5) CFU/ml.

Substance Class	Mixture Created by `admin` on `Mon Mar 31 18:40:36 GMT 2025` Edited by `admin` on `Mon Mar 31 18:40:36 GMT 2025`
Record UNII	PP922A42V2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BAMBERMYCIN

Preferred Name

English

BAMBERMYCINS

Official Name

English

BAMBERMYCINS, UNSPECIFIED

Common Name

English

BAMBERMYCINS [MI]

Common Name

English

bambermycin [INN]

Common Name

English

BAMBERMYCINS [USAN]

Common Name

English

BAMBERMYCIN [MART.]

Common Name

English

FLAVOPHOSPHOLIPOL

Common Name

English

MOENOMYCIN

Common Name

English

BAMBERMYCINS [GREEN BOOK]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C258