Bambermycins (flavomycin) is a complex of antibiotics obtained from Streptomyces bambergiensis and Streptomyces ghanaensis used as a food additive for poultry and swine. Inhibitor of the in vitro transglycosylase activities of PBPs. Bambermycins complex consists mainly of moenomycins A and C. Moenomycin A is the prototype for compounds that bind to bacterial peptidoglycan glycosyltransferases (PGTs) and inhibit cell wall biosynthesis
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | GAINPRO Approved UseFor increased rate of weight gain and improved feed efficiency in cattle fed in confinement for slaughter (feedlot cattle). For increased rate of weight gain in pasture cattle (slaughter, stocker and feeder cattle, and dairy and beef replacement heifers). Launch Date1998 |
Sample Use Guides
Chickens: 1-2 Grams
Swine: 2 Grams
It is recommended that Flavomycin 4 (Bambermycins) be diluted with a suitable grain carrier before addition to the final feed.
A dilution of 1 part of Flavomycin 4 and 9 parts grain carrier is the suggested working premix.
Route of Administration:
Oral
Of 10 predominant bacterial genera from the fresh human fecal
samples, Fusobacterium spp. and Lactobacillus spp. were the most
sensitively affected by flavomycin (Bambermycins) showing MIC50 value of
0.25 ug/ml at 1 x10(5) CFU/ml. ATCC-type Fusobacterium prausnitzii
was also the most sensitive bacterium with same MIC value
0.25 ug/ml at 1x 10(5) CFU/ml.
| Substance Class |
Mixture
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PP922A42V2
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C258
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21 CFR 558.95
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21 CFR 558.95
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