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Description

Bambermycins (flavomycin) is a complex of antibiotics obtained from Streptomyces bambergiensis and Streptomyces ghanaensis used as a food additive for poultry and swine. Inhibitor of the in vitro transglycosylase activities of PBPs. Bambermycins complex consists mainly of moenomycins A and C. Moenomycin A is the prototype for compounds that bind to bacterial peptidoglycan glycosyltransferases (PGTs) and inhibit cell wall biosynthesis

Approval Year

2009
359
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
GAINPRO

Approved Use

For increased rate of weight gain and improved feed efficiency in cattle fed in confinement for slaughter (feedlot cattle). For increased rate of weight gain in pasture cattle (slaughter, stocker and feeder cattle, and dairy and beef replacement heifers).

Launch Date

1998
PubMed

PubMed

TitleDatePubMed
Effect of flavophospholipol on conjugation frequency between Escherichia coli donor and recipient pairs in vitro and in the chicken gastrointestinal tract.
2006 Aug
Risk assessment of ciprofloxacin, flavomycin, olaquindox and colistin sulfate based on microbiological impact on human gut biota.
2009 Apr
Complete characterization of the seventeen step moenomycin biosynthetic pathway.
2009 Sep 22
Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors.
2013 Mar 13
Patents

Patents

CA2614904A1
1
CN101381722B
1

Sample Use Guides

In Vivo Use Guide
Chickens: 1-2 Grams Swine: 2 Grams It is recommended that Flavomycin 4 (Bambermycins) be diluted with a suitable grain carrier before addition to the final feed. A dilution of 1 part of Flavomycin 4 and 9 parts grain carrier is the suggested working premix.
Route of Administration: Oral
In Vitro Use Guide
Of 10 predominant bacterial genera from the fresh human fecal samples, Fusobacterium spp. and Lactobacillus spp. were the most sensitively affected by flavomycin (Bambermycins) showing MIC50 value of 0.25 ug/ml at 1 x10(5) CFU/ml. ATCC-type Fusobacterium prausnitzii was also the most sensitive bacterium with same MIC value 0.25 ug/ml at 1x 10(5) CFU/ml.
Substance Class Mixture
Created
by admin
on Fri Dec 15 17:06:15 GMT 2023
Edited
by admin
on Fri Dec 15 17:06:15 GMT 2023
Record UNII
PP922A42V2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BAMBERMYCINS
GREEN BOOK   MI   USAN  
USAN  
Official Name English
BAMBERMYCIN
INN   MART.  
INN  
Official Name English
BAMBERMYCINS, UNSPECIFIED
Common Name English
BAMBERMYCINS [MI]
Common Name English
bambermycin [INN]
Common Name English
BAMBERMYCINS [USAN]
Common Name English
BAMBERMYCIN [MART.]
Common Name English
FLAVOPHOSPHOLIPOL
Common Name English
MOENOMYCIN
Common Name English
BAMBERMYCINS [GREEN BOOK]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C258
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
CFR 21 CFR 558.95
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
CFR 21 CFR 558.95
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
Code System Code Type Description
RXCUI
1367176
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID90891348
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY
DAILYMED
PP922A42V2
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY
CAS
11015-37-5
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY
WIKIPEDIA
Bambermycin
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY
MERCK INDEX
m2215
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY Merck Index
CHEBI
28908
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY
FDA UNII
PP922A42V2
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY
INN
2666
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY
ChEMBL
CHEMBL2108902
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY
DRUG BANK
DB11377
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY
NCI_THESAURUS
C90675
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY
ECHA (EC/EINECS)
234-246-7
Created by admin on Fri Dec 15 17:06:15 GMT 2023 , Edited by admin on Fri Dec 15 17:06:15 GMT 2023
PRIMARY
One of these components may be present:
STREPTOMYCES GEYSIRIENSIS ANTIBIOTIC COMPLEX
STREPTOMYCES GHANAENSIS ANTIBIOTIC COMPLEX
STREPTOMYCES BAMBERGIENSIS ANTIBIOTIC COMPLEX
STREPTOMYCES EDERENSIS ANTIBIOTIC COMPLEX
Related Record Type Details
BAMBERMYCINS
ACTIVE MOIETY
Definition References
NIH
NCATS
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