Carbomycin is a complex mixture containing carbomycin A with a small portion of carbomycin B. Carbomycin is produced by Streptomyces halstedii and acts as an antibiotic. The drug was approved by FDA under the name Magna-terramycin (in combination with oxytetracycline) for the treatment of bacterial chronic respiratory diseases in chickens. Carbomycin exerts its antibacterial action by binding within the large ribosomal subunit and thus inhibiting the protein synthesis in bacterias.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2363135 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | MAGNA-TERRAMYCIN Approved UseAs an aid in the prevention and treatment of complicated chronic respiratory disease (air-sac infection) caused by Mycoplasma gallisepticum and secondary bacterial organisms associated with chronic respiratory disease such as E. coli. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| The treatment of infectious diseases: advances in the use of antimicrobial drugs. | 1953 Oct |
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| The dried disc technique with bacitracin, carbomycin, erythromycin, polymyxin B, and tetracycline. | 1955 May |
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| Bacteriophage types and antibiotic sensitivity of staphylococci from bovine milk and human nares. | 1965 Sep |
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| Mutant of Staphylococcus aureus with lincomycin- and carbomycin-inducible resistance to erythromycin. | 1974 May |
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| Cytoplasmic inheritance of erythromycin resistance in human cells. | 1979 Sep |
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| Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. | 1982 May |
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| Nucleotide sequence analysis of the carbomycin biosynthetic genes including the 3-O-acyltransferase gene from Streptomyces thermotolerans. | 1995 Apr |
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| Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library. | 2014 Jul |
Patents
Sample Use Guides
1.0 gram of oxytetracycline as oxytetracycline hydrochloride and 1.0 gram carbomycin as carbomycin base per gallon of drinking water.
Route of Administration:
Oral
| Substance Class |
Mixture
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21 CFR 520.1660A
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CFR |
21 CFR 556.110
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C166659
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300000036856
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CHEMBL2104385
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CARBOMYCIN
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ACTIVE MOIETY |
