TOCOPHEROL

US Previously Marketed

First marketed in 1921

Description
Sources: http://www.eisai.jp/medical/products/di/EPI/EN_C-SC-FG_EPI.pdf
Curator's Comment: Description was created based on several sources, including https://www.springboard4health.com/notebook/v_e.html and http://www.ncbi.nlm.nih.gov/pubmed/2134664

Tocopherol (alpha tocopheryl nicotinate) is an ester of tocopherol and nicotinic acid. Vitamin E (Tocopherol) is sold commercially as the esterified form (alpha tocopheryl acetate, alpha tocopheryl succinate and alpha tocopheryl nicotinate). Alpha tocopheryl nicotinate has antioxidant and vasodilatory properties. It can be used as a mild warming agent, without producing the redness typical for nicotinic acid. Tocopherol (alpha tocopheryl nicotinate) has been available in Japan since 1967. Tocopherol under the brand name Juvela N is approved in Japan for the treatment of symptoms accompanying hypertension, hyperlipidemia, peripheral circulatory disturbance resulting from arteriosclerosis obliterans. Tocopherol has being shown to inhibit platelet aggregation.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
platelet aggregation 75 Target ID: GO:0070527 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2134664	Inhibitor 8146
platelet aggregation 75 Target ID: GO:0070527 Sources: https://www.ncbi.nlm.nih.gov/pubmed/835140 \| https://www.ncbi.nlm.nih.gov/pubmed/835137	Inhibitor 8146
Oxidative Stress 162 Target ID: WP408 Sources: https://www.ulprospector.com/en/na/PersonalCare/Detail/611/77797/Vitamin-E-Nicotinate \| https://www.ncbi.nlm.nih.gov/pubmed/28472095	Inhibitor 8146

Conditions

Condition	Modality	Highest Phase	Product
Hypertension 546 Sources: http://www.eisai.jp/medical/products/di/EPI/EN_C-SC-FG_EPI.pdf	Primary	Approved 8307	Juvela N Approved Use Accompanying symptoms resulting from the following Hypertension Hyperlipidemia Peripheral circulatory disturbance resulting from the following Arteriosclerosis obliterans Launch Date -9.4780801E10
Hyperlipidemia 75 Sources: http://www.eisai.jp/medical/products/di/EPI/EN_C-SC-FG_EPI.pdf	Primary	Approved 8307	Juvela N Approved Use Accompanying symptoms resulting from the following Hypertension Hyperlipidemia Peripheral circulatory disturbance resulting from the following Arteriosclerosis obliterans Launch Date -9.4780801E10
Arteriosclerosis obliterans 7 Sources: http://www.eisai.jp/medical/products/di/EPI/EN_C-SC-FG_EPI.pdf	Primary	Approved 8307	Juvela N Approved Use Accompanying symptoms resulting from the following Hypertension Hyperlipidemia Peripheral circulatory disturbance resulting from the following Arteriosclerosis obliterans Launch Date -9.4780801E10

PubMed

Title	Date	PubMed
A family of familial hypercholesterolemia with cerebral infarction and without coronary heart disease. An unusual case with corneal opacity, polyneuropathy and carpal tunnel syndrome in the family: therapy with probucol and tocopherol nicotinate.	1991 Nov	1779233
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.	2002	12537931
UPLC method for the determination of vitamin E homologues and derivatives in vegetable oils, margarines and supplement capsules using pentafluorophenyl column.	2014 Dec	25159413

Patents

Sample Use Guides

In Vivo Use Guide

The usual adult dosage for oral use is 300 - 600 mg of tocopherol nicotinate (3 - 6 capsules) daily in three divided doses

Route of Administration: Oral

In Vitro Use Guide

177 uM of Tocopherol led to decreased human platelet aggregation in response to the combined ADP and H2O 2

Substance Class	Mixture Created by `admin` on `Fri Dec 16 23:50:38 UTC 2022` Edited by `admin` on `Fri Dec 16 23:50:38 UTC 2022`
Record UNII	R0ZB2556P8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TOCOPHEROL

Official Name

English

RRR-TOCOPHEROLS CONCENTRATE, MIXED

Common Name

English

TOCOPHEROL [II]

Common Name

English

ORISTAR MIXED TOCOPHEROLS

Brand Name

English

TOCOPHEROLS

Common Name

English

TOCOPHEROL [VANDF]

Common Name

English

COVI-OX T 70 C

Brand Name

English

TOCOPHEROL [INCI]

Common Name

English

MIXED TOCOPHEROLS

Common Name

English

Tocopherols mixed [WHO-DD]

Common Name

English

RACEMIC MIXTURE OF ALPHA-TOCOPHEROL, DELTA-TOCOPHEROL AND GAMMA-TOCOPHEROL

Common Name

English

TOCOPHEROL [JAN]

Common Name

English

TOCOPHEROLS (MIXED)

Common Name

English

RRR-TOCOPHEROLS CONCENTRATE, MIXED [FCC]

Common Name

English

COVI-OX T 50 C

Brand Name

English

MIXED TOCOPHEROLS 95

Brand Name

English

Tocopherol [WHO-DD]

Common Name

English

E-306

Common Name

English

Classification Tree Code System Code

WHO-VATC

QA11HA03