Tannic acid (TA) is a naturally occurring plant-derived polyphenol found in several herbaceous and woody plants, wines and a broad selection of teas. TA has strong antioxidant/free radical scavenging, anti-inflammatory, anti-viral/bacterial, and anti-carcinogenic properties. The neuroprotective effects of TA against Alzheimer’s disease (AD) have been shown in several in vitro and in vivo models of AD. Evidence suggests that TA is a natural inhibitor of β-secretase (BACE1) activity and protein expression. BACE1 is the primary enzyme responsible for the production and deposition of Aβ peptide. TA can also inhibit the in vitro aggregation of tau peptide, a core component of intracellular neurofibrillary tangles (NFTs). In addition, combination of tannic acid with eucalyptus Oil and Allantoin (from Comfrey) is known as homeopathic product which is used to temporarily relieve the aches and pains of muscles and joints associated with: arthritis, simple backache, strains, bruises, sprains.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22219198
Curator's Comment: TANNIC ACID (TA) is a high molecular weight molecule that does not easily penetrate the cell or freely cross the blood-brain barrier. Nonetheless, TA is metabolized into much lower molecular weight, absorbable tannins that are biologically active in various organs including the brain
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL4803 Sources: https://www.scbt.com/p/gallotannin-1401-55-4 |
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Target ID: CHEMBL4481 Sources: https://www.scbt.com/p/gallotannin-1401-55-4 |
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Target ID: CHEMBL3568 Sources: https://www.scbt.com/p/gallotannin-1401-55-4 |
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Target ID: CHEMBL4822 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22219198 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | DEPINAR Approved UseUnknown Launch Date1980 |
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Palliative | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Tannin inhibits HIV-1 entry by targeting gp41. | 2004 Feb |
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Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. | 2005 Nov |
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A mammalian two-hybrid system-based assay for small-molecular HIV fusion inhibitors targeting gp41. | 2011 Apr |
Sample Use Guides
4JOINTZ- eucalyptus oil, tannic acid, allantoin cream: use only as directed. Aadults & children 12 years and older: massage gently into affected joints apply three (3) times daily for optimal results
Route of Administration:
Topical
In Vitro Use Guide
Sources: https://doi.org/10.1515/aoas-2016-0059
An in vitro gas production technique, using rumen fluid from four Kacang x Boer crossbred adult goats was used to study the effects of commercial tannic acid (TA, a hydrolysable tannin) on methanogenesis, fatty acid composition and biohydrogenation (BH) of C18 polyunsaturated fatty acids (PUFA) in the rumen. Treatments were control (CON, 50% alfalfa hay (AH) + 50% concentrate), 25mg TA/250mg DM (LTA, low TA) and 50mg TA/250mg DM (HTA, High TA) were mixed with 30 mL of buffered rumen fluid and were incubated for 24 h. The study revealed that TA supplementation had no negative effect on rumen fermentation parameters such as pH, NH3N, acetic/propionic ratio and total volatile fatty acid (tVFA). Methane (CH4) production (mL/250mg DM) decreased (P<0.05) with increasing levels of TA. Greatest CH4 reduction (%) was recorded for MTA (20.30 %) and LTA (13.00 %) compared with CON. The addition of TA in vitro reduced rumen methanogenesis without negative effect of rumen fermentation characteristic.
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NCI_THESAURUS |
C28203
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EPA PESTICIDE CODE |
78502
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CFR |
21 CFR 310.538
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JECFA EVALUATION |
TANNIC ACID
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CFR |
21 CFR 184.1097
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ACTIVE MOIETY