U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Tannic acid (TA) is a naturally occurring plant-derived polyphenol found in several herbaceous and woody plants, wines and a broad selection of teas. TA has strong antioxidant/free radical scavenging, anti-inflammatory, anti-viral/bacterial, and anti-carcinogenic properties. The neuroprotective effects of TA against Alzheimer’s disease (AD) have been shown in several in vitro and in vivo models of AD. Evidence suggests that TA is a natural inhibitor of β-secretase (BACE1) activity and protein expression. BACE1 is the primary enzyme responsible for the production and deposition of Aβ peptide. TA can also inhibit the in vitro aggregation of tau peptide, a core component of intracellular neurofibrillary tangles (NFTs). In addition, combination of tannic acid with eucalyptus Oil and Allantoin (from Comfrey) is known as homeopathic product which is used to temporarily relieve the aches and pains of muscles and joints associated with: arthritis, simple backache, strains, bruises, sprains.

CNS Activity

Curator's Comment: TANNIC ACID (TA) is a high molecular weight molecule that does not easily penetrate the cell or freely cross the blood-brain barrier. Nonetheless, TA is metabolized into much lower molecular weight, absorbable tannins that are biologically active in various organs including the brain

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DEPINAR

Approved Use

Unknown

Launch Date

1980
Palliative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Tannin inhibits HIV-1 entry by targeting gp41.
2004 Feb
Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system.
2005 Nov
A mammalian two-hybrid system-based assay for small-molecular HIV fusion inhibitors targeting gp41.
2011 Apr
Patents

Sample Use Guides

4JOINTZ- eucalyptus oil, tannic acid, allantoin cream: use only as directed. Aadults & children 12 years and older: massage gently into affected joints apply three (3) times daily for optimal results
Route of Administration: Topical
In Vitro Use Guide
An in vitro gas production technique, using rumen fluid from four Kacang x Boer crossbred adult goats was used to study the effects of commercial tannic acid (TA, a hydrolysable tannin) on methanogenesis, fatty acid composition and biohydrogenation (BH) of C18 polyunsaturated fatty acids (PUFA) in the rumen. Treatments were control (CON, 50% alfalfa hay (AH) + 50% concentrate), 25mg TA/250mg DM (LTA, low TA) and 50mg TA/250mg DM (HTA, High TA) were mixed with 30 mL of buffered rumen fluid and were incubated for 24 h. The study revealed that TA supplementation had no negative effect on rumen fermentation parameters such as pH, NH3N, acetic/propionic ratio and total volatile fatty acid (tVFA). Methane (CH4) production (mL/250mg DM) decreased (P<0.05) with increasing levels of TA. Greatest CH4 reduction (%) was recorded for MTA (20.30 %) and LTA (13.00 %) compared with CON. The addition of TA in vitro reduced rumen methanogenesis without negative effect of rumen fermentation characteristic.
Name Type Language
TANNIC ACID
EP   FCC   FHFI   INCI   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INCI  
Official Name English
GALLOTANNIN
Common Name English
TANNIC ACID [JAN]
Common Name English
TANNIC ACID [EP IMPURITY]
Common Name English
OC-108 COMPONENT TANNIC ACID
Common Name English
TANNIC ACID [USP MONOGRAPH]
Common Name English
TANNIC ACID [MI]
Common Name English
DEPINAR COMPONENT TANNIC ACID
Common Name English
TANNIC ACID COMPONENT OF DEPINAR
Common Name English
TANNIC ACID [FHFI]
Common Name English
TANNICUM ACIDUM [HPUS]
Common Name English
TANNIC ACID, UNSPECIFIED
Common Name English
TANNIC ACID [EP MONOGRAPH]
Common Name English
GALLOTANNIC ACID
Common Name English
NSC-758670
Code English
TANNIC ACID [USP-RS]
Common Name English
NSC-656273
Code English
TANNIC ACID [FCC]
Common Name English
TANNIC ACID [ORANGE BOOK]
Common Name English
FEMA NO. 3042
Code English
Tannic acid [WHO-DD]
Common Name English
TANNIC ACID [INCI]
Common Name English
TANNICUM ACIDUM
HPUS  
Common Name English
TANNIC ACID [VANDF]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C28203
Created by admin on Fri Dec 15 16:36:27 GMT 2023 , Edited by admin on Fri Dec 15 16:36:27 GMT 2023
EPA PESTICIDE CODE 78502
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CFR 21 CFR 310.538
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JECFA EVALUATION TANNIC ACID
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CFR 21 CFR 184.1097
Created by admin on Fri Dec 15 16:36:27 GMT 2023 , Edited by admin on Fri Dec 15 16:36:27 GMT 2023
Code System Code Type Description
NSC
656273
Created by admin on Fri Dec 15 16:36:27 GMT 2023 , Edited by admin on Fri Dec 15 16:36:27 GMT 2023
PRIMARY
FDA UNII
28F9E0DJY6
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PRIMARY
RXCUI
10328
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PRIMARY RxNorm
NCI_THESAURUS
C66579
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PRIMARY
RS_ITEM_NUM
1643328
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PRIMARY
NCI_THESAURUS
C45678
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CONCEPT Industrial Aid
PUBCHEM
16129778
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PRIMARY
MERCK INDEX
m10454
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PRIMARY Merck Index
ECHA (EC/EINECS)
215-753-2
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PRIMARY
DAILYMED
28F9E0DJY6
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PRIMARY
ChEMBL
CHEMBL506247
Created by admin on Fri Dec 15 16:36:27 GMT 2023 , Edited by admin on Fri Dec 15 16:36:27 GMT 2023
PRIMARY
DRUG CENTRAL
5039
Created by admin on Fri Dec 15 16:36:27 GMT 2023 , Edited by admin on Fri Dec 15 16:36:27 GMT 2023
PRIMARY
WIKIPEDIA
TANNIC ACID
Created by admin on Fri Dec 15 16:36:27 GMT 2023 , Edited by admin on Fri Dec 15 16:36:27 GMT 2023
PRIMARY
CAS
1401-55-4
Created by admin on Fri Dec 15 16:36:27 GMT 2023 , Edited by admin on Fri Dec 15 16:36:27 GMT 2023
PRIMARY
CHEBI
3884
Created by admin on Fri Dec 15 16:36:27 GMT 2023 , Edited by admin on Fri Dec 15 16:36:27 GMT 2023
PRIMARY
NSC
758670
Created by admin on Fri Dec 15 16:36:27 GMT 2023 , Edited by admin on Fri Dec 15 16:36:27 GMT 2023
PRIMARY
DRUG BANK
DB09372
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PRIMARY
EVMPD
SUB15451MIG
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PRIMARY
Definition References