U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Description
Curator's Comment:: Description was created based on several sources, including https://www.springboard4health.com/notebook/v_e.html and http://www.ncbi.nlm.nih.gov/pubmed/2134664

Tocopherol (alpha tocopheryl nicotinate) is an ester of tocopherol and nicotinic acid. Vitamin E (Tocopherol) is sold commercially as the esterified form (alpha tocopheryl acetate, alpha tocopheryl succinate and alpha tocopheryl nicotinate). Alpha tocopheryl nicotinate has antioxidant and vasodilatory properties. It can be used as a mild warming agent, without producing the redness typical for nicotinic acid. Tocopherol (alpha tocopheryl nicotinate) has been available in Japan since 1967. Tocopherol under the brand name Juvela N is approved in Japan for the treatment of symptoms accompanying hypertension, hyperlipidemia, peripheral circulatory disturbance resulting from arteriosclerosis obliterans. Tocopherol has being shown to inhibit platelet aggregation.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Juvela N

Approved Use

Accompanying symptoms resulting from the following Hypertension Hyperlipidemia Peripheral circulatory disturbance resulting from the following Arteriosclerosis obliterans

Launch Date

-9.4780801E10
Primary
Juvela N

Approved Use

Accompanying symptoms resulting from the following Hypertension Hyperlipidemia Peripheral circulatory disturbance resulting from the following Arteriosclerosis obliterans

Launch Date

-9.4780801E10
Primary
Juvela N

Approved Use

Accompanying symptoms resulting from the following Hypertension Hyperlipidemia Peripheral circulatory disturbance resulting from the following Arteriosclerosis obliterans

Launch Date

-9.4780801E10
PubMed

PubMed

TitleDatePubMed
A family of familial hypercholesterolemia with cerebral infarction and without coronary heart disease. An unusual case with corneal opacity, polyneuropathy and carpal tunnel syndrome in the family: therapy with probucol and tocopherol nicotinate.
1991 Nov
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.
2002
UPLC method for the determination of vitamin E homologues and derivatives in vegetable oils, margarines and supplement capsules using pentafluorophenyl column.
2014 Dec
Patents

Sample Use Guides

The usual adult dosage for oral use is 300 - 600 mg of tocopherol nicotinate (3 - 6 capsules) daily in three divided doses
Route of Administration: Oral
In Vitro Use Guide
177 uM of Tocopherol led to decreased human platelet aggregation in response to the combined ADP and H2O 2
Name Type Language
TOCOPHEROL
II   INCI   VANDF   WHO-DD  
INCI  
Official Name English
RRR-TOCOPHEROLS CONCENTRATE, MIXED
FCC  
Common Name English
TOCOPHEROL [II]
Common Name English
ORISTAR MIXED TOCOPHEROLS
Brand Name English
TOCOPHEROLS
Common Name English
TOCOPHEROL [VANDF]
Common Name English
COVI-OX T 70 C
Brand Name English
TOCOPHEROL [INCI]
Common Name English
MIXED TOCOPHEROLS
Common Name English
RACEMIC MIXTURE OF ALPHA-TOCOPHEROL, DELTA-TOCOPHEROL AND GAMMA-TOCOPHEROL
Common Name English
TOCOPHEROLS (MIXED)
Common Name English
RRR-TOCOPHEROLS CONCENTRATE, MIXED [FCC]
Common Name English
COVI-OX T 50 C
Brand Name English
MIXED TOCOPHEROLS 95
Brand Name English
E-306
Common Name English
TOCOPHEROL [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-VATC QA11HA03
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
WHO-ATC A11HA03
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
LOINC 29747-3
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
LOINC 87672-2
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
LOINC 47791-9
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
LOINC 59250-1
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
LOINC 74544-8
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
Code System Code Type Description
RXCUI
1236136
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
PRIMARY RxNorm
EPA CompTox
1406-66-2
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
PRIMARY
ChEMBL
CHEMBL47
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
PRIMARY
CAS
1406-66-2
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
PRIMARY
EVMPD
SUB15582MIG
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
PRIMARY
NCI_THESAURUS
C68313
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
PRIMARY
DRUG BANK
DB11251
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
PRIMARY
EVMPD
SUB15583MIG
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
ALTERNATIVE
MESH
D024505
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
PRIMARY
FDA UNII
R0ZB2556P8
Created by admin on Sat Jun 26 19:14:55 UTC 2021 , Edited by admin on Sat Jun 26 19:14:55 UTC 2021
PRIMARY
Definition References