Amiphenazole, a respiratory stimulant, can be used parenteral and oral. Nicholas Laboratories marketed it under the trade name Daptazole. It was used to treat chronic respiratory failure, by increasing ventilation and by reduction of the pCO2 in some patients. Increased ventilation was brought about by an increase in tidal volume rather than an increase in respiratory rate. In combination with bemegride, amiphenazole was used as an antidote for barbiturate, glutethimide overdose, as well as poisoning from other sedative drugs. Now, this drug is used very rarely, because it replaced by more effective drugs.

Amineptine is a selective inhibitor of dopamine reuptake. The drug was developed in France and was marketed for the treatment of depressive disorders under the name Survector among the others. Amineptine was withdrawn from the French market in 1999 because of abuse and drug dependence and because of its hepatic (cholestatic injuries) and cutaneous (acne) adverse effects.

Bluensomycin is an aminocyclitol antibiotic obtained from cultures of Streptomyces verticillus. In vivo it has been found to be effective against experimental Staphylococcus aureus infections in mice. Preliminary tests against a variety of microorganisms of human origin revealed that bluensomycin inhibited S. aureus, Proteus mirabilis, Streptococcus (Group D), and Nocardia asteroides. Escherichia coil, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, and Aspergillus nidulans were insensitive to inhibition by bluensomycin.

Mecysteine is used as a mucolytic in respiratory disorders associated with productive cough. Mecysteine is known as a mucolytic agent, it breaks down mucus. It works by breaking some of the chemical bonds between the molecules in mucus. It is given orally in a usual dose of 200 mg three times daily before meals reduced to 200 mg twice daily after 6 weeks. A rapid clinical effect can be achieved by giving 200 mg four times daily for the first 2 days. Mecysteine has also been given by inhalation.

Meladrazine is a drug used in urology as an antispasmodic. Meladrazine acts on the central nervous system as a polysynaptic inhibitor. Its usefulness in treating spasticity in patients with multiple sclerosis is well known. As many of these patients have bladder problems, a coincidental beneficial effect on uninhibited bladders has been discovered. Meladrazine caused a high incidence of side effects; therefore, treatment with terodiline separately is recommended for geriatric patients who have severe motor urge incontinence.

Linsidomine (SIN-1, chemically 3-morpholinosydnonimin), is a vasodilator and antianginal drug. It is the direct hepatic metabolite of molsidomine. The dosage recommended by its manufacturer for its initial purpose, coronary angiography, is 0.4-1 mg. Contrary to molsidomine, which is widely used as an antianginal drug, linsidomine is used only for coronary angiography. The plasma half-life of Linsidomine is about 1 hour. Linsidomine is nonenzymatically metabolized to SIN-1A which spontaneously releases NO. NO, probably released directly from nonadrenergic, noncholinergic (NANC) nerves in the penis, is believed to cause smooth muscle relaxation by stimulating the soluble form of guanylate cyclase leading to an increase of intracellular cyclic guanosine 3',5' monophosphate (cGMP) with subsequent smooth muscle relaxation. Linsidomine also hyperpolarizes the cell membrane, making the smooth muscle less susceptible to adrenergic stimulation. NO further interacts with platelets when released intraluminally causing an increase in cGMP that decreases platelet aggregation and adhesion

Zidometacin is a nonsteroidal anti-inflammatory agent structurally related to indomethacin that has been studied for osteoarthritis treatment. Pharmacological studies show its favorable activity/ulcerogenicity ratio in comparison to indomethacin. Preliminary clinical data indicate a good analgesic effect after a single dose and an improvement of functional conditions of the joint after short-term therapy. Zidometacin either as capsules or as suppositories showed a statistically significant influence on pain and functional indices in osteoarthritis patients. The side-effects reported by patients were dizziness and nausea with capsules and anal burning with suppositories.

Sulfaguanol (Enterocura), an antibacterial sulfanilamide drug that was used for patients with acute diarrhea

Deprodone is a steroid that was approved in Japan for the treatment of inflammatory skin disorders. The drug is marketed under the name Eclar and contains 0.3% of the prodrug, deprodone propionate.

Perfluorobutane (PFB) is an inert, high-density colorless gas used as a replacement for Halon 1301 in fire extinguishers, as well as the gas component for newer generation microbubble ultrasound contrast agents. Perflubutane has been used in clinical trials for the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. Perflubutane perfusion echocardiography has the potential to be a cost-effective and convenient alternative to nuclear perfusion imaging. Ultrasound enhanced with Perflubutane was able to image myocardial perfusion and obtain information that appears comparable to nuclear imaging.