DEPRODONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H28O4
Molecular Weight	344.4446
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C

InChI

InChIKey=KQZSMOGWYFPKCH-UJPCIWJBSA-N

InChI=1S/C21H28O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h6,8,10,15-18,24-25H,4-5,7,9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H28O4
Molecular Weight	344.4446
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=32407

Deprodone is a steroid that was approved in Japan for the treatment of inflammatory skin disorders. The drug is marketed under the name Eclar and contains 0.3% of the prodrug, deprodone propionate.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Inflammatory skin diseases 5 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=32407	Primary		Approved 8583	ECLAR Approved Use It is usually used to treat eczema, dermatitis, drug eruption, insect sting, prurigo, psoriasis, erythroderma, erythema, palmoplanter pustulosis, alopecia areata, etc.

Doses

Dose	Population	Adverse events
0.3 % 1 times / day multiple, topical Recommended Dose: 0.3 %, 1 times / day Route: topical Route: multiple Dose: 0.3 %, 1 times / day Sources: https://www.rad-ar.or.jp/siori/english/kekka.cgi?n=32407	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://www.rad-ar.or.jp/siori/english/kekka.cgi?n=32407	Disc. AE: Ocular hypertension, Posterior capsule opacification... Other AEs: Glaucoma... AEs leading to discontinuation/dose reduction: Ocular hypertension Posterior capsule opacification Other AEs: Glaucoma Sources: https://www.rad-ar.or.jp/siori/english/kekka.cgi?n=32407

AEs

AE	Significance	Dose	Population
Glaucoma		0.3 % 1 times / day multiple, topical Recommended Dose: 0.3 %, 1 times / day Route: topical Route: multiple Dose: 0.3 %, 1 times / day Sources: https://www.rad-ar.or.jp/siori/english/kekka.cgi?n=32407	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://www.rad-ar.or.jp/siori/english/kekka.cgi?n=32407
Ocular hypertension	Disc. AE	0.3 % 1 times / day multiple, topical Recommended Dose: 0.3 %, 1 times / day Route: topical Route: multiple Dose: 0.3 %, 1 times / day Sources: https://www.rad-ar.or.jp/siori/english/kekka.cgi?n=32407	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://www.rad-ar.or.jp/siori/english/kekka.cgi?n=32407
Posterior capsule opacification	Disc. AE	0.3 % 1 times / day multiple, topical Recommended Dose: 0.3 %, 1 times / day Route: topical Route: multiple Dose: 0.3 %, 1 times / day Sources: https://www.rad-ar.or.jp/siori/english/kekka.cgi?n=32407	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://www.rad-ar.or.jp/siori/english/kekka.cgi?n=32407

Patents

Sample Use Guides

In Vivo Use Guide

Deprodone (ointment or cream containing 0.3% deprodone propionate) is applied to the affected area, once to several times a day.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:26:19 GMT 2025` Edited by `admin` on `Mon Mar 31 18:26:19 GMT 2025`
Record UNII	Z380L7N00P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DEPRODONE [MART.]

Preferred Name

English

DEPRODONE

Official Name

English

Deprodone [WHO-DD]

Common Name

English

deprodone [INN]

Common Name

English

11.BETA.,17-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE

Systematic Name

English

PREDNISOLONE ACETATE IMPURITY D [EP IMPURITY]

Common Name

English

11.BETA.,17-DIHYDROXYPREGNA-1,4-DIENE3,20-DIONE

Systematic Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 11,17-DIHYDROXY-, (11.BETA.)-

Systematic Name

English

DESOLONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521