AMINEPTINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H27NO2
Molecular Weight	337.4553
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CCCCCCNC1C2=CC=CC=C2CCC3=CC=CC=C13

InChI

InChIKey=ONNOFKFOZAJDHT-UHFFFAOYSA-N

InChI=1S/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)

HIDE SMILES / InChI

Description
Sources: http://www.has-sante.fr/portail/upload/docs/application/pdf/2013-08/stablon_ct_10411_12029.pdf | www.ncbi.nlm.nih.gov/pubmed/21584062

Amineptine is a selective inhibitor of dopamine reuptake. The drug was developed in France and was marketed for the treatment of depressive disorders under the name Survector among the others. Amineptine was withdrawn from the French market in 1999 because of abuse and drug dependence and because of its hepatic (cholestatic injuries) and cutaneous (acne) adverse effects.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine transporter 183 Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21584062	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Major depression 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21584062	Primary		Withdrawn	Survector Approved Use Survector 100mg tablet is used in the treatment of depression. Launch Date 1977

PubMed

Title	Date	PubMed
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010-12	21818443
Amineptine treatment of persistent catatonic symptoms in schizophrenia: a controlled study.	2010-12	21220791
Management of anorexia and bulimia nervosa: An evidence-based review.	2010-04	20838508
Research on antidepressants in India.	2010-01	21836704
Molecular biology research in neuropsychiatry: India's contribution.	2010-01	21836667
A new strategy for antidepressant prescription.	2010	21151361
Prevalence of antidepressants and biosimilars in elite sport.	2009-06	20355208
Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis.	2009-06	19440080
Treatment for amphetamine withdrawal.	2009-04-15	19370579
Spectroscopic and electrochemical analysis of psychotropic drugs.	2009-01	20177449
Pharmacological and combined interventions for the acute depressive episode: focus on efficacy and tolerability.	2009	19956554
Update on the management of symptoms in schizophrenia: focus on amisulpride.	2009	19557121
Venlafaxine dependence in a patient with a history of alcohol and amineptine misuse.	2008-09	18636997
Improving pain management communication: how patients understand the terms "opioid" and "narcotic".	2008-09	18516649
Addressing the paradoxes of satisfaction with hospital care.	2008	19055265
Utility of 7,7,8,8-tetracyanoquinodimethane charge transfer reagent for the spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides.	2007-12-31	17376736
Is it possible to be dependent to Tianeptine, an antidepressant? A case report.	2007-04-13	17270334
Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation with molybdenum and thiocyanate.	2006-12	16829178
Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation using methyl orange and bromocresol green reagents.	2006-09	16527524
Antidepressants for anorexia nervosa.	2006-01-25	16437485
[A case of tianeptine abuse].	2006	16528638
[Acne induced by amineptine].	2005-09-16	19377762
Fluoxetine dependence in a former amineptine abuser.	2005-03-15	15764428
Role of presynaptic alpha2-adrenoceptors in antidepressant action: recent findings from microdialysis studies.	2004-08	15363606
Discriminating different classes of toxicants by transcript profiling.	2004-08	15345370
Sex-dependent modulation of treatment response.	2004-03	22034399
[Does addiction to antidepressants exist? About a case of one addiction to tianeptine].	2003-11-15	14615695
Sleep-wake mechanisms and drug discovery: sleep EEG as a tool for the development of CNS-acting drugs.	2002-12	22034388
[A case of Parkinson syndrome secondary to combined amineptine and bromazepam abuse].	1998-12-16	9850824
Amineptine in the treatment of amphetamine withdrawal: a placebo-controlled, randomised, double-blind study.	1997-09	9347672
[Acne induced by amineptin: adnexal toxiderma].	1996	9636770
The serotonin syndrome.	1992-10	1530086
[Immediate acute hepatic cytolysis after the administration of a single amineptin tablet].	1992	1397859
[Amineptin dependence and iatrogenic acne. Review of the literature apropos of a case].	1991-12	1839203
[Amineptin dependence. Detection of patients at risk. Report of 8 cases].	1990-09-01	2265603
[Amineptin abuse. Analysis of 155 cases. An evaluation of the official cooperative survey of the Regional Centers of Pharmacovigilance].	1990-09-01	2260032
Genetic predisposition to drug hepatotoxicity: role in hepatitis caused by amineptine, a tricyclic antidepressant.	1989-08	2744728
[Acneiform eruption induced by amineptin (Survector)].	1989	2534534
[Rosaceous drug eruption caused by amineptin (Survector)].	1988	2977084
[Iatrogenic acne caused by amineptin (Survector). Apropos of 8 cases].	1988	2977080
[Value of amineptin in the treatment of different depressive states. Apropos of 112 cases treated as part of a national multi-centric study].	1985-07-01	4085404
[Amineptin-induced hepatitis: differential diagnosis of biliary microlithiasis].	1982-11	7152215
[Hepatitis due to amineptin. 4 cases].	1982-11	7152212
[A study of three potential antidepressants (amineptin, mianserin and nomifensin) on the cardiovascular system and isolated intestine (author's transl)].	1982-06-10	6287607
[Effects of thymo-analeptics and acceptability of amineptin compared to those of imipramine].	1982	7186460
[Extensive multicentric study of 1354 cases of depressed subjects treated with amineptin].	1982	6764624
[Hepatitis, cholestasis and amineptine (author's transl)].	1981-12-18	6276980
[Hepatitis caused by amineptine : a case with reintroduction of the drug].	1981-11	7308682
[The problem of side-effects: cardiotoxicity (author's transl)].	1981	7318761
[Amineptine-induced cholestatic hepatitis. 5 cases (author's transl)].	1980-12-20	7454584

Patents

Sample Use Guides

In Vivo Use Guide

Patients receive 200 mg of amineptine (survector) daily, in two divided doses at 8 A.M. and 12 noon for 6 weeks.

Route of Administration: Oral

In Vitro Use Guide

Rat neurones were treated with 300 nM-30uM of amineptine. Amineptine (1-30uM) decreased spontaneous firing and slightly hyperpolarized the membrane potential. At 300 nM-30uM amineptine increased the amplitude and duration of responses to exogenously applied dopamine.

Name

Type

Language

AMINEPTINE

Official Name

English

AMINEPTIN

Preferred Name

English

7-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)amino]heptanoic acid

Systematic Name

English

AMINEPTINE [MI]

Common Name

English

DEA NO. 1219

Common Name

English

Amineptine [WHO-DD]

Common Name

English

amineptine [INN]

Common Name

English

Classification Tree Code System Code

DEA NO.

1219