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Details

Stereochemistry ACHIRAL
Molecular Formula C22H27NO2
Molecular Weight 337.4561
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMINEPTINE

SMILES

C(CCCNC1c2ccccc2CCc3ccccc31)CCC(=O)O

InChI

InChIKey=ONNOFKFOZAJDHT-UHFFFAOYSA-N
InChI=1S/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)

HIDE SMILES / InChI
Amineptine is a selective inhibitor of dopamine reuptake. The drug was developed in France and was marketed for the treatment of depressive disorders under the name Survector among the others. Amineptine was withdrawn from the French market in 1999 because of abuse and drug dependence and because of its hepatic (cholestatic injuries) and cutaneous (acne) adverse effects.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Survector

Approved Use

Survector 100mg tablet is used in the treatment of depression.

Launch Date

252460800000
PubMed

PubMed

TitleDatePubMed
[Amineptine-induced cholestatic hepatitis. 5 cases (author's transl)].
1980 Dec 20
[The problem of side-effects: cardiotoxicity (author's transl)].
1981
[Hepatitis caused by amineptine : a case with reintroduction of the drug].
1981 Nov
[Amineptin dependence and iatrogenic acne. Review of the literature apropos of a case].
1991 Dec
[Acne induced by amineptin: adnexal toxiderma].
1996
Amineptine in the treatment of amphetamine withdrawal: a placebo-controlled, randomised, double-blind study.
1997 Sep
[A case of Parkinson syndrome secondary to combined amineptine and bromazepam abuse].
1998 Sep-Oct
Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction.
2001
[Liver damage and nonsteroidal anti-inflammatory drugs: case non-case study in the French Pharmacovigilance Database].
2001 Jan-Feb
Acneiform eruption caused by amineptine. A case report and review of the literature.
2001 Jul
Social stress in anorexia nervosa: a review of immuno-endocrine relationships.
2001 Jun
Observation of psychoactive substance consumption: methods and results of the French OPPIDUM programme.
2001 Mar
Dopaminergic augmentation of sleep deprivation effects in bipolar depression.
2001 Nov 30
Methylphenidate in stimulants abuse: three case reports.
2001 Spring
Benefits and risks of pharmacotherapy for dysthymia: a systematic appraisal of the evidence.
2003
Addressing the paradoxes of satisfaction with hospital care.
2008
Pharmacological and combined interventions for the acute depressive episode: focus on efficacy and tolerability.
2009
Update on the management of symptoms in schizophrenia: focus on amisulpride.
2009
Treatment for amphetamine withdrawal.
2009 Apr 15
Spectroscopic and electrochemical analysis of psychotropic drugs.
2009 Jan
[Acne induced by amineptine].
2009 Jan-Feb
Prevalence of antidepressants and biosimilars in elite sport.
2009 Jun
Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis.
2009 Jun
Amineptine treatment of persistent catatonic symptoms in schizophrenia: a controlled study.
2010 Dec
Research on antidepressants in India.
2010 Jan
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Sources: www.ncbi.nlm.nih.gov/pubmed/21584062
Patients receive 200 mg of amineptine (survector) daily, in two divided doses at 8 A.M. and 12 noon for 6 weeks.
Route of Administration: Oral
In Vitro Use Guide
Rat neurones were treated with 300 nM-30uM of amineptine. Amineptine (1-30uM) decreased spontaneous firing and slightly hyperpolarized the membrane potential. At 300 nM-30uM amineptine increased the amplitude and duration of responses to exogenously applied dopamine.
Name Type Language
AMINEPTINE
INN   MI   WHO-DD  
INN  
Official Name English
7-((10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YL)AMINO)HEPTANOIC ACID
Systematic Name English
AMINEPTINE [MI]
Common Name English
AMINEPTINE [WHO-DD]
Common Name English
AMINEPTIN
Common Name English
AMINEPTINE [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QN06AA19
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
WHO-ATC N06AA19
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
NCI_THESAURUS C265
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
Code System Code Type Description
EPA CompTox
57574-09-1
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
RXCUI
17698
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY RxNorm
INN
3998
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
WIKIPEDIA
AMINEPTINE
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
MESH
C011597
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
MERCK INDEX
M1673
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY Merck Index
EVMPD
SUB05435MIG
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
NCI_THESAURUS
C74142
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
ECHA (EC/EINECS)
260-818-0
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
PUBCHEM
34870
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
FDA UNII
27T1I13L6G
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
DRUG CENTRAL
161
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
ChEMBL
CHEMBL418995
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
CAS
57574-09-1
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY
DRUG BANK
DB04836
Created by admin on Sat Jun 26 06:31:49 UTC 2021 , Edited by admin on Sat Jun 26 06:31:49 UTC 2021
PRIMARY