Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H27NO2.ClH |
Molecular Weight | 373.916 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.OC(=O)CCCCCCNC1C2=CC=CC=C2CCC3=C1C=CC=C3
InChI
InChIKey=VDPUXONTAVMIKZ-UHFFFAOYSA-N
InChI=1S/C22H27NO2.ClH/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22;/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25);1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C22H27NO2 |
Molecular Weight | 337.4553 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Amineptine is a selective inhibitor of dopamine reuptake. The drug was developed in France and was marketed for the treatment of depressive disorders under the name Survector among the others. Amineptine was withdrawn from the French market in 1999 because of abuse and drug dependence and because of its hepatic (cholestatic injuries) and cutaneous (acne) adverse effects.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21584062 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Survector Approved UseSurvector 100mg tablet is used in the treatment of depression. Launch Date1977 |
PubMed
Title | Date | PubMed |
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[The problem of side-effects: cardiotoxicity (author's transl)]. | 1981 |
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[Hepatitis, cholestasis and amineptine (author's transl)]. | 1981 Dec 18-25 |
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[Value of amineptin in the treatment of different depressive states. Apropos of 112 cases treated as part of a national multi-centric study]. | 1985 Jul-Aug |
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[Amineptin abuse. Analysis of 155 cases. An evaluation of the official cooperative survey of the Regional Centers of Pharmacovigilance]. | 1990 Sep-Oct |
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[Amineptin dependence and iatrogenic acne. Review of the literature apropos of a case]. | 1991 Dec |
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[Acne induced by amineptin: adnexal toxiderma]. | 1996 |
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Amineptine in the treatment of amphetamine withdrawal: a placebo-controlled, randomised, double-blind study. | 1997 Sep |
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WHO Expert Committee on Drug Dependence. Thirty-second report. | 2001 |
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Acneiform eruption caused by amineptine. A case report and review of the literature. | 2001 Jul |
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Observation of psychoactive substance consumption: methods and results of the French OPPIDUM programme. | 2001 Mar |
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Dopaminergic augmentation of sleep deprivation effects in bipolar depression. | 2001 Nov 30 |
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Sex-dependent modulation of treatment response. | 2004 Mar |
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Antidepressants for anorexia nervosa. | 2006 Jan 25 |
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[A case of tianeptine abuse]. | 2006 Spring |
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[Acne induced by amineptine]. | 2009 Jan-Feb |
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Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis. | 2009 Jun |
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A new strategy for antidepressant prescription. | 2010 |
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Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
|
Molecular biology research in neuropsychiatry: India's contribution. | 2010 Jan |
Patents
Sample Use Guides
Patients receive 200 mg of amineptine (survector) daily, in two divided doses at 8 A.M. and 12 noon for 6 weeks.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1797329
Rat neurones were treated with 300 nM-30uM of amineptine. Amineptine (1-30uM) decreased spontaneous firing and slightly hyperpolarized the membrane potential. At 300 nM-30uM amineptine increased the amplitude and duration of responses to exogenously applied dopamine.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:00:55 GMT 2023
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on
Fri Dec 15 17:00:55 GMT 2023
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Record UNII |
A5P604A12R
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Record Status |
Validated (UNII)
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Record Version |
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