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Details

Stereochemistry ACHIRAL
Molecular Formula C22H27NO2.ClH
Molecular Weight 373.916
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMINEPTINE HYDROCHLORIDE

SMILES

Cl.OC(=O)CCCCCCNC1C2=CC=CC=C2CCC3=C1C=CC=C3

InChI

InChIKey=VDPUXONTAVMIKZ-UHFFFAOYSA-N
InChI=1S/C22H27NO2.ClH/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22;/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25);1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C22H27NO2
Molecular Weight 337.4553
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Amineptine is a selective inhibitor of dopamine reuptake. The drug was developed in France and was marketed for the treatment of depressive disorders under the name Survector among the others. Amineptine was withdrawn from the French market in 1999 because of abuse and drug dependence and because of its hepatic (cholestatic injuries) and cutaneous (acne) adverse effects.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Survector

Approved Use

Survector 100mg tablet is used in the treatment of depression.

Launch Date

2.52460794E11
PubMed

PubMed

TitleDatePubMed
[Hepatitis, cholestasis and amineptine (author's transl)].
1981 Dec 18-25
[Effects of thymo-analeptics and acceptability of amineptin compared to those of imipramine].
1982
[Extensive multicentric study of 1354 cases of depressed subjects treated with amineptin].
1982
[Value of amineptin in the treatment of different depressive states. Apropos of 112 cases treated as part of a national multi-centric study].
1985 Jul-Aug
[Rosaceous drug eruption caused by amineptin (Survector)].
1988
[Amineptin dependence. Detection of patients at risk. Report of 8 cases].
1990 Sep-Oct
[Amineptin dependence and iatrogenic acne. Review of the literature apropos of a case].
1991 Dec
WHO Expert Committee on Drug Dependence. Thirty-second report.
2001
[Liver damage and nonsteroidal anti-inflammatory drugs: case non-case study in the French Pharmacovigilance Database].
2001 Jan-Feb
Social stress in anorexia nervosa: a review of immuno-endocrine relationships.
2001 Jun
Sex-dependent modulation of treatment response.
2004 Mar
[A case of tianeptine abuse].
2006 Spring
Is it possible to be dependent to Tianeptine, an antidepressant? A case report.
2007 Apr 13
Spectroscopic and electrochemical analysis of psychotropic drugs.
2009 Jan
[Acne induced by amineptine].
2009 Jan-Feb
Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis.
2009 Jun
A new strategy for antidepressant prescription.
2010
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Sources: www.ncbi.nlm.nih.gov/pubmed/21584062
Patients receive 200 mg of amineptine (survector) daily, in two divided doses at 8 A.M. and 12 noon for 6 weeks.
Route of Administration: Oral
In Vitro Use Guide
Rat neurones were treated with 300 nM-30uM of amineptine. Amineptine (1-30uM) decreased spontaneous firing and slightly hyperpolarized the membrane potential. At 300 nM-30uM amineptine increased the amplitude and duration of responses to exogenously applied dopamine.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:00:55 UTC 2023
Edited
by admin
on Fri Dec 15 17:00:55 UTC 2023
Record UNII
A5P604A12R
Record Status Validated (UNII)
Record Version
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Name Type Language
AMINEPTINE HYDROCHLORIDE
MART.   MI   WHO-DD  
Common Name English
HEPTANOIC ACID, 7-((10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YL)AMINO)-, HYDROCHLORIDE (1:1)
Common Name English
AMINEPTINE HYDROCHLORIDE [MART.]
Common Name English
7-((10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YL)AMINO)HEPTANOIC ACID MONOHYDROCHLORIDE
Systematic Name English
SURVECTOR
Brand Name English
S-1694
Code English
AMINEPTINE HCL
Common Name English
AMINEPTINE HYDROCHLORIDE [MI]
Common Name English
MANEON
Brand Name English
Amineptine hydrochloride [WHO-DD]
Common Name English
AMINEPTENE HYDROCHLORIDE
Common Name English
Code System Code Type Description
CHEBI
32499
Created by admin on Fri Dec 15 17:00:55 UTC 2023 , Edited by admin on Fri Dec 15 17:00:55 UTC 2023
PRIMARY
ECHA (EC/EINECS)
250-107-3
Created by admin on Fri Dec 15 17:00:55 UTC 2023 , Edited by admin on Fri Dec 15 17:00:55 UTC 2023
PRIMARY
DRUG BANK
DBSALT000803
Created by admin on Fri Dec 15 17:00:55 UTC 2023 , Edited by admin on Fri Dec 15 17:00:55 UTC 2023
PRIMARY
EVMPD
SUB00447MIG
Created by admin on Fri Dec 15 17:00:55 UTC 2023 , Edited by admin on Fri Dec 15 17:00:55 UTC 2023
PRIMARY
CAS
30272-08-3
Created by admin on Fri Dec 15 17:00:55 UTC 2023 , Edited by admin on Fri Dec 15 17:00:55 UTC 2023
PRIMARY
FDA UNII
A5P604A12R
Created by admin on Fri Dec 15 17:00:55 UTC 2023 , Edited by admin on Fri Dec 15 17:00:55 UTC 2023
PRIMARY
MERCK INDEX
m1673
Created by admin on Fri Dec 15 17:00:55 UTC 2023 , Edited by admin on Fri Dec 15 17:00:55 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID20952633
Created by admin on Fri Dec 15 17:00:55 UTC 2023 , Edited by admin on Fri Dec 15 17:00:55 UTC 2023
PRIMARY
SMS_ID
100000085152
Created by admin on Fri Dec 15 17:00:55 UTC 2023 , Edited by admin on Fri Dec 15 17:00:55 UTC 2023
PRIMARY
PUBCHEM
34869
Created by admin on Fri Dec 15 17:00:55 UTC 2023 , Edited by admin on Fri Dec 15 17:00:55 UTC 2023
PRIMARY
CHEBI
50003
Created by admin on Fri Dec 15 17:00:55 UTC 2023 , Edited by admin on Fri Dec 15 17:00:55 UTC 2023
PRIMARY
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