AMINEPTINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H27NO2.ClH
Molecular Weight	373.916
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.OC(=O)CCCCCCNC1C2=CC=CC=C2CCC3=C1C=CC=C3

InChI

InChIKey=VDPUXONTAVMIKZ-UHFFFAOYSA-N

InChI=1S/C22H27NO2.ClH/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22;/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C22H27NO2
Molecular Weight	337.4553
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.has-sante.fr/portail/upload/docs/application/pdf/2013-08/stablon_ct_10411_12029.pdf | www.ncbi.nlm.nih.gov/pubmed/21584062

Amineptine is a selective inhibitor of dopamine reuptake. The drug was developed in France and was marketed for the treatment of depressive disorders under the name Survector among the others. Amineptine was withdrawn from the French market in 1999 because of abuse and drug dependence and because of its hepatic (cholestatic injuries) and cutaneous (acne) adverse effects.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine transporter 180 Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21584062	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Major depression 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21584062	Primary		Withdrawn	Survector Approved Use Survector 100mg tablet is used in the treatment of depression. Launch Date 2.52460794E11

PubMed

Title	Date	PubMed
[The problem of side-effects: cardiotoxicity (author's transl)].	1981	7318761
[Hepatitis caused by amineptine : a case with reintroduction of the drug].	1981 Nov	7308682
[Extensive multicentric study of 1354 cases of depressed subjects treated with amineptin].	1982	6764624
[Rosaceous drug eruption caused by amineptin (Survector)].	1988	2977084
[Immediate acute hepatic cytolysis after the administration of a single amineptin tablet].	1992	1397859
The serotonin syndrome.	1992 Oct	1530086
[Acne induced by amineptin: adnexal toxiderma].	1996	9636770
Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction.	2001	11229449
[Liver damage and nonsteroidal anti-inflammatory drugs: case non-case study in the French Pharmacovigilance Database].	2001 Jan-Feb	11322018
Acneiform eruption caused by amineptine. A case report and review of the literature.	2001 Jul	11730047
Social stress in anorexia nervosa: a review of immuno-endocrine relationships.	2001 Jun	11438363
WHO Expert Committee on Drug Dependence.	2003	12772439
Sex-dependent modulation of treatment response.	2004 Mar	22034399
Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation with molybdenum and thiocyanate.	2006 Dec	16829178
Is it possible to be dependent to Tianeptine, an antidepressant? A case report.	2007 Apr 13	17270334
Addressing the paradoxes of satisfaction with hospital care.	2008	19055265
Venlafaxine dependence in a patient with a history of alcohol and amineptine misuse.	2008 Sep	18636997
Treatment for amphetamine withdrawal.	2009 Apr 15	19370579
Spectroscopic and electrochemical analysis of psychotropic drugs.	2009 Jan	20177449
Prevalence of antidepressants and biosimilars in elite sport.	2009 Jun	20355208

Patents

Sample Use Guides

In Vivo Use Guide

Patients receive 200 mg of amineptine (survector) daily, in two divided doses at 8 A.M. and 12 noon for 6 weeks.

Route of Administration: Oral

In Vitro Use Guide

Rat neurones were treated with 300 nM-30uM of amineptine. Amineptine (1-30uM) decreased spontaneous firing and slightly hyperpolarized the membrane potential. At 300 nM-30uM amineptine increased the amplitude and duration of responses to exogenously applied dopamine.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:00:55 UTC 2023` Edited by `admin` on `Fri Dec 15 17:00:55 UTC 2023`
Record UNII	A5P604A12R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMINEPTINE HYDROCHLORIDE

Common Name

English

HEPTANOIC ACID, 7-((10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YL)AMINO)-, HYDROCHLORIDE (1:1)

Common Name

English

AMINEPTINE HYDROCHLORIDE [MART.]

Common Name

English

7-((10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YL)AMINO)HEPTANOIC ACID MONOHYDROCHLORIDE

Systematic Name

English

SURVECTOR

Brand Name

English

S-1694

Code

English

AMINEPTINE HCL

Common Name

English

AMINEPTINE HYDROCHLORIDE [MI]

Common Name

English

MANEON

Brand Name

English

Amineptine hydrochloride [WHO-DD]

Common Name

English

AMINEPTENE HYDROCHLORIDE

Common Name

English

Code System Code Type Description

CHEBI

32499