Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H27NO2.ClH |
| Molecular Weight | 373.916 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.OC(=O)CCCCCCNC1C2=CC=CC=C2CCC3=C1C=CC=C3
InChI
InChIKey=VDPUXONTAVMIKZ-UHFFFAOYSA-N
InChI=1S/C22H27NO2.ClH/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22;/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25);1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C22H27NO2 |
| Molecular Weight | 337.4553 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Amineptine is a selective inhibitor of dopamine reuptake. The drug was developed in France and was marketed for the treatment of depressive disorders under the name Survector among the others. Amineptine was withdrawn from the French market in 1999 because of abuse and drug dependence and because of its hepatic (cholestatic injuries) and cutaneous (acne) adverse effects.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Amineptine-induced cholestatic hepatitis. 5 cases (author's transl)]. | 1980 Dec 20 |
|
| [The problem of side-effects: cardiotoxicity (author's transl)]. | 1981 |
|
| [Hepatitis, cholestasis and amineptine (author's transl)]. | 1981 Dec 18-25 |
|
| [Hepatitis caused by amineptine : a case with reintroduction of the drug]. | 1981 Nov |
|
| [Effects of thymo-analeptics and acceptability of amineptin compared to those of imipramine]. | 1982 |
|
| [Extensive multicentric study of 1354 cases of depressed subjects treated with amineptin]. | 1982 |
|
| [A study of three potential antidepressants (amineptin, mianserin and nomifensin) on the cardiovascular system and isolated intestine (author's transl)]. | 1982 Jun 10 |
|
| [Amineptin-induced hepatitis: differential diagnosis of biliary microlithiasis]. | 1982 Nov |
|
| [Hepatitis due to amineptin. 4 cases]. | 1982 Nov |
|
| [Value of amineptin in the treatment of different depressive states. Apropos of 112 cases treated as part of a national multi-centric study]. | 1985 Jul-Aug |
|
| [Rosaceous drug eruption caused by amineptin (Survector)]. | 1988 |
|
| [Iatrogenic acne caused by amineptin (Survector). Apropos of 8 cases]. | 1988 |
|
| [Acneiform eruption induced by amineptin (Survector)]. | 1989 |
|
| Genetic predisposition to drug hepatotoxicity: role in hepatitis caused by amineptine, a tricyclic antidepressant. | 1989 Aug |
|
| [Amineptin dependence. Detection of patients at risk. Report of 8 cases]. | 1990 Sep-Oct |
|
| [Amineptin abuse. Analysis of 155 cases. An evaluation of the official cooperative survey of the Regional Centers of Pharmacovigilance]. | 1990 Sep-Oct |
|
| [Amineptin dependence and iatrogenic acne. Review of the literature apropos of a case]. | 1991 Dec |
|
| [Acne induced by amineptin: adnexal toxiderma]. | 1996 |
|
| Amineptine in the treatment of amphetamine withdrawal: a placebo-controlled, randomised, double-blind study. | 1997 Sep |
|
| [A case of Parkinson syndrome secondary to combined amineptine and bromazepam abuse]. | 1998 Sep-Oct |
|
| WHO Expert Committee on Drug Dependence. Thirty-second report. | 2001 |
|
| Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. | 2001 |
|
| [Liver damage and nonsteroidal anti-inflammatory drugs: case non-case study in the French Pharmacovigilance Database]. | 2001 Jan-Feb |
|
| Acneiform eruption caused by amineptine. A case report and review of the literature. | 2001 Jul |
|
| Observation of psychoactive substance consumption: methods and results of the French OPPIDUM programme. | 2001 Mar |
|
| Sleep-wake mechanisms and drug discovery: sleep EEG as a tool for the development of CNS-acting drugs. | 2002 Dec |
|
| Role of presynaptic alpha2-adrenoceptors in antidepressant action: recent findings from microdialysis studies. | 2004 Aug |
|
| Sex-dependent modulation of treatment response. | 2004 Mar |
|
| Fluoxetine dependence in a former amineptine abuser. | 2004 Oct-Dec |
|
| Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation using methyl orange and bromocresol green reagents. | 2006 Sep |
|
| Utility of 7,7,8,8-tetracyanoquinodimethane charge transfer reagent for the spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides. | 2007 Dec 31 |
|
| Addressing the paradoxes of satisfaction with hospital care. | 2008 |
|
| Venlafaxine dependence in a patient with a history of alcohol and amineptine misuse. | 2008 Sep |
|
| Improving pain management communication: how patients understand the terms "opioid" and "narcotic". | 2008 Sep |
|
| Pharmacological and combined interventions for the acute depressive episode: focus on efficacy and tolerability. | 2009 |
|
| Update on the management of symptoms in schizophrenia: focus on amisulpride. | 2009 |
|
| Treatment for amphetamine withdrawal. | 2009 Apr 15 |
|
| Spectroscopic and electrochemical analysis of psychotropic drugs. | 2009 Jan |
|
| [Acne induced by amineptine]. | 2009 Jan-Feb |
|
| Prevalence of antidepressants and biosimilars in elite sport. | 2009 Jun |
|
| Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis. | 2009 Jun |
|
| A new strategy for antidepressant prescription. | 2010 |
|
| Management of anorexia and bulimia nervosa: An evidence-based review. | 2010 Apr |
|
| Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
|
| Amineptine treatment of persistent catatonic symptoms in schizophrenia: a controlled study. | 2010 Dec |
|
| Research on antidepressants in India. | 2010 Jan |
|
| Molecular biology research in neuropsychiatry: India's contribution. | 2010 Jan |
Patents
Sample Use Guides
Patients receive 200 mg of amineptine (survector) daily, in two divided doses at 8 A.M. and 12 noon for 6 weeks.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
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A5P604A12R
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