Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H27NO2 |
Molecular Weight | 337.4553 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCCCCCNC1C2=CC=CC=C2CCC3=C1C=CC=C3
InChI
InChIKey=ONNOFKFOZAJDHT-UHFFFAOYSA-N
InChI=1S/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)
Molecular Formula | C22H27NO2 |
Molecular Weight | 337.4553 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Amineptine is a selective inhibitor of dopamine reuptake. The drug was developed in France and was marketed for the treatment of depressive disorders under the name Survector among the others. Amineptine was withdrawn from the French market in 1999 because of abuse and drug dependence and because of its hepatic (cholestatic injuries) and cutaneous (acne) adverse effects.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21584062 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Survector Approved UseSurvector 100mg tablet is used in the treatment of depression. Launch Date2.52460794E11 |
PubMed
Title | Date | PubMed |
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[The problem of side-effects: cardiotoxicity (author's transl)]. | 1981 |
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[Hepatitis caused by amineptine : a case with reintroduction of the drug]. | 1981 Nov |
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[Acneiform eruption induced by amineptin (Survector)]. | 1989 |
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WHO Expert Committee on Drug Dependence. Thirty-second report. | 2001 |
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Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. | 2001 |
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Observation of psychoactive substance consumption: methods and results of the French OPPIDUM programme. | 2001 Mar |
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Sleep-wake mechanisms and drug discovery: sleep EEG as a tool for the development of CNS-acting drugs. | 2002 Dec |
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WHO Expert Committee on Drug Dependence. | 2003 |
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Benefits and risks of pharmacotherapy for dysthymia: a systematic appraisal of the evidence. | 2003 |
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Role of presynaptic alpha2-adrenoceptors in antidepressant action: recent findings from microdialysis studies. | 2004 Aug |
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Discriminating different classes of toxicants by transcript profiling. | 2004 Aug |
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Fluoxetine dependence in a former amineptine abuser. | 2004 Oct-Dec |
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Antidepressants for anorexia nervosa. | 2006 Jan 25 |
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Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation using methyl orange and bromocresol green reagents. | 2006 Sep |
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Update on the management of symptoms in schizophrenia: focus on amisulpride. | 2009 |
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Prevalence of antidepressants and biosimilars in elite sport. | 2009 Jun |
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Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
Patents
Sample Use Guides
Patients receive 200 mg of amineptine (survector) daily, in two divided doses at 8 A.M. and 12 noon for 6 weeks.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1797329
Rat neurones were treated with 300 nM-30uM of amineptine. Amineptine (1-30uM) decreased spontaneous firing and slightly hyperpolarized the membrane potential. At 300 nM-30uM amineptine increased the amplitude and duration of responses to exogenously applied dopamine.
Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 16:23:46 UTC 2023
by
admin
on
Fri Dec 15 16:23:46 UTC 2023
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Record UNII |
27T1I13L6G
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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DEA NO. |
1219
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WHO-VATC |
QN06AA19
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WHO-ATC |
N06AA19
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NCI_THESAURUS |
C265
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DTXSID1048831
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100000087225
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17698
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3998
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AMINEPTINE
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C011597
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m1673
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32499
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SUB05435MIG
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C74142
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260-818-0
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34870
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27T1I13L6G
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161
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CHEMBL418995
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57574-09-1
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DB04836
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
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