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Details

Stereochemistry ACHIRAL
Molecular Formula C9H9N3S
Molecular Weight 191.253
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMIPHENAZOLE

SMILES

NC1=NC(N)=C(S1)C2=CC=CC=C2

InChI

InChIKey=UPOYFZYFGWBUKL-UHFFFAOYSA-N
InChI=1S/C9H9N3S/c10-8-7(13-9(11)12-8)6-4-2-1-3-5-6/h1-5H,10H2,(H2,11,12)

HIDE SMILES / InChI

Molecular Formula C9H9N3S
Molecular Weight 191.253
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Amiphenazole, a respiratory stimulant, can be used parenteral and oral. Nicholas Laboratories marketed it under the trade name Daptazole. It was used to treat chronic respiratory failure, by increasing ventilation and by reduction of the pCO2 in some patients. Increased ventilation was brought about by an increase in tidal volume rather than an increase in respiratory rate. In combination with bemegride, amiphenazole was used as an antidote for barbiturate, glutethimide overdose, as well as poisoning from other sedative drugs. Now, this drug is used very rarely, because it replaced by more effective drugs.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Daptazole

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Massive doses of bemegride and amiphenazole in treatment of barbiturate poisoning.
1958 Mar 29
ORAL AMIPHENAZOLE IN CHRONIC RESPIRATORY FAILURE.
1963 Oct

Sample Use Guides

oral: 100 mg (Daptazole 100) intravenous: 100, 150 mg intramuscular: 75, 100 mg
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:23:47 GMT 2023
Edited
by admin
on Fri Dec 15 16:23:47 GMT 2023
Record UNII
7ZJ8PWY0XD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMIPHENAZOLE
INN   MI   WHO-DD  
INN  
Official Name English
AMIPHENAZOLE [MI]
Common Name English
2,4-DIAMINO-5-PHENYLTHIAZOLE
Systematic Name English
Amiphenazole [WHO-DD]
Common Name English
amiphenazole [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47795
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
Code System Code Type Description
PUBCHEM
10275
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
MERCK INDEX
m1749
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
207-713-8
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
WIKIPEDIA
Amiphenazole
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
INN
510
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
NCI_THESAURUS
C74238
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
EVMPD
SUB05453MIG
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
MESH
C004484
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
FDA UNII
7ZJ8PWY0XD
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
SMS_ID
100000087231
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
ChEMBL
CHEMBL1514085
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
EPA CompTox
DTXSID7046388
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
DRUG CENTRAL
177
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
CAS
490-55-1
Created by admin on Fri Dec 15 16:23:47 GMT 2023 , Edited by admin on Fri Dec 15 16:23:47 GMT 2023
PRIMARY
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SALT/SOLVATE -> PARENT
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