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Details

Stereochemistry ACHIRAL
Molecular Formula C9H9N3S.ClH
Molecular Weight 227.714
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMIPHENAZOLE HYDROCHLORIDE

SMILES

Cl.NC1=NC(N)=C(S1)C2=CC=CC=C2

InChI

InChIKey=AGSXNJJBDIOXIP-UHFFFAOYSA-N
InChI=1S/C9H9N3S.ClH/c10-8-7(13-9(11)12-8)6-4-2-1-3-5-6;/h1-5H,10H2,(H2,11,12);1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C9H9N3S
Molecular Weight 191.253
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Amiphenazole, a respiratory stimulant, can be used parenteral and oral. Nicholas Laboratories marketed it under the trade name Daptazole. It was used to treat chronic respiratory failure, by increasing ventilation and by reduction of the pCO2 in some patients. Increased ventilation was brought about by an increase in tidal volume rather than an increase in respiratory rate. In combination with bemegride, amiphenazole was used as an antidote for barbiturate, glutethimide overdose, as well as poisoning from other sedative drugs. Now, this drug is used very rarely, because it replaced by more effective drugs.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Daptazole
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
oral: 100 mg (Daptazole 100) intravenous: 100, 150 mg intramuscular: 75, 100 mg
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
W6W4748LIO
Record Status Validated (UNII)
Record Version