PERFLUBUTANE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4F10
Molecular Weight	238.0268
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F

InChI

InChIKey=KAVGMUDTWQVPDF-UHFFFAOYSA-N

InChI=1S/C4F10/c5-1(6,3(9,10)11)2(7,8)4(12,13)14

HIDE SMILES / InChI

Molecular Formula	C4F10
Molecular Weight	238.0268
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26895755 | https://www.ncbi.nlm.nih.gov/pubmed/24004871 | https://www.ncbi.nlm.nih.gov/pubmed/17489666 | https://www.ncbi.nlm.nih.gov/pubmed/28141517

Perfluorobutane (PFB) is an inert, high-density colorless gas used as a replacement for Halon 1301 in fire extinguishers, as well as the gas component for newer generation microbubble ultrasound contrast agents. Perflubutane has been used in clinical trials for the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. Perflubutane perfusion echocardiography has the potential to be a cost-effective and convenient alternative to nuclear perfusion imaging. Ultrasound enhanced with Perflubutane was able to image myocardial perfusion and obtain information that appears comparable to nuclear imaging.

Approval Year

PubMed

Title	Date	PubMed
Dynamics and fragmentation of thick-shelled microbubbles.	2002 Oct	12403141
Intestinal and hepatic lesions in mice, rats, and other laboratory animals after intravenous administration of gas-carrier contrast agents used in ultrasound imaging.	2003 May 1	12729716
A respiration-metabolism chamber system and a GC-MS method developed for studying exhalation of perfluorobutane in rats after intravenous injection of the ultrasound contrast agent Sonazoid.	2005 Sep 15	15964732
Value of adenosine infusion for infarct size determination using real-time myocardial contrast echocardiography.	2006 Feb 8	16466579
Microvascular behavior and effects of sonazoid microbubbles in the cremaster muscle of rats after local administration.	2006 Jul	16798899
Molecular mechanics (MM4) study of fluorinated hydrocarbons.	2006 Jun 8	16737272
Atmospheric chemistry of N-methyl perfluorobutane sulfonamidoethanol, C4F9SO2N(CH3)CH2CH2OH: kinetics and mechanism of reaction with OH.	2006 Mar 15	16570609
Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow.	2006 Nov-Dec	17191766
AI-700 pharmacokinetics, tissue distribution and exhaled elimination kinetics in rats.	2007 Jan 2	16950578
Acute and chronic effects of perfluorobutane sulfonate (PFBS) on the mallard and northern bobwhite quail.	2008 Apr	17917760
Focal liver tumors: characterization with 3D perflubutane microbubble contrast agent-enhanced US versus 3D contrast-enhanced multidetector CT.	2009 Apr	19221060
Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging.	2009 Jan	19131498
Definition of contrast enhancement phases of the liver using a perfluoro-based microbubble agent, perflubutane microbubbles.	2009 Nov	19713032
Perfluorinated compounds in sediments from the Daliao River system of northeast China.	2009 Oct	19735931
Polyfluorinated compounds in waste water treatment plant effluents and surface waters along the River Elbe, Germany.	2009 Sep	19501845
One-year follow-up of perfluorinated compounds in plasma of German residents from Arnsberg formerly exposed to PFOA-contaminated drinking water.	2009 Sep	19464951
Structure-activity relationships and human relevance for perfluoroalkyl acid-induced transcriptional activation of peroxisome proliferation in liver cell cultures.	2009 Sep	19407336
Contrast enhanced ultrasound of hepatocellular carcinoma.	2010 Feb 28	21160920
Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ.	2014 Sep 15	24998974

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:22:19 GMT 2023` Edited by `admin` on `Fri Dec 15 16:22:19 GMT 2023`
Record UNII	SE4TWR0K2C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PERFLUBUTANE

Official Name

English

AI-700

Code

English

SONAZOID

Brand Name

English

PERFLUBUTANE [JAN]

Common Name

English

Decafluorobutane

Systematic Name

English

perflubutane [INN]

Common Name

English

PERFLUBUTANE [USAN]

Common Name

English

Perflubutane [WHO-DD]

Common Name

English

BUTANE, DECAFLUORO-

Systematic Name

English

PERFLUBUTANE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

V08DA06