PERFLUBUTANE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4F10
Molecular Weight	238.0268
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F

InChI

InChIKey=KAVGMUDTWQVPDF-UHFFFAOYSA-N

InChI=1S/C4F10/c5-1(6,3(9,10)11)2(7,8)4(12,13)14

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26895755 | https://www.ncbi.nlm.nih.gov/pubmed/24004871 | https://www.ncbi.nlm.nih.gov/pubmed/17489666 | https://www.ncbi.nlm.nih.gov/pubmed/28141517

Perfluorobutane (PFB) is an inert, high-density colorless gas used as a replacement for Halon 1301 in fire extinguishers, as well as the gas component for newer generation microbubble ultrasound contrast agents. Perflubutane has been used in clinical trials for the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. Perflubutane perfusion echocardiography has the potential to be a cost-effective and convenient alternative to nuclear perfusion imaging. Ultrasound enhanced with Perflubutane was able to image myocardial perfusion and obtain information that appears comparable to nuclear imaging.

Approval Year

PubMed

Title	Date	PubMed
Gateways to clinical trials.	2006 Dec	17235418
Removal of perfluorinated surfactants by sorption onto granular activated carbon, zeolite and sludge.	2008 Aug	18511099
Developmental neurotoxicity of perfluorinated chemicals modeled in vitro.	2008 Jun	18560525
Focal liver tumors: characterization with 3D perflubutane microbubble contrast agent-enhanced US versus 3D contrast-enhanced multidetector CT.	2009 Apr	19221060
Definition of contrast enhancement phases of the liver using a perfluoro-based microbubble agent, perflubutane microbubbles.	2009 Nov	19713032
Perfluorinated compounds in sediments from the Daliao River system of northeast China.	2009 Oct	19735931
Preserving enhancement in freeze-dried contrast agent ST68: Examination of excipients.	2010 Aug 30	20540998
Cooperative infrared to visible up conversion in Tb3+, Eu3+, And Yb3+ containing polymers.	2010 Dec 14	20886560
Perfluorinated compounds in urban river sediments from Guangzhou and Shanghai of China.	2010 Jun	20430414
Distribution and sources of polyfluoroalkyl substances (PFAS) in the River Rhine watershed.	2010 Oct	20692748
Spatial distribution and sources of perfluorochemicals in the NW Mediterranean coastal waters (Catalonia, Spain).	2010 Sep	20630635
Ecotoxicological assessment of surfactants in the aquatic environment: combined toxicity of docusate sodium with chlorinated pollutants.	2010 Sep	20579683
Microfluidic assembly of monodisperse, nanoparticle-incorporated perfluorocarbon microbubbles for medical imaging and therapy.	2010 Sep 7	20666507

Name

Type

Language

PERFLUBUTANE

Official Name

English

AI-700

Code

English

SONAZOID

Brand Name

English

PERFLUBUTANE [JAN]

Common Name

English

Decafluorobutane

Systematic Name

English

perflubutane [INN]

Common Name

English

PERFLUBUTANE [USAN]

Common Name

English

Perflubutane [WHO-DD]

Common Name

English

BUTANE, DECAFLUORO-

Systematic Name

English

PERFLUBUTANE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

V08DA06